Tag

Hypertension

40 genetic variants with this tag.

RSID	Gene	Description	Category
rs1008899	NEDD4L	Intronic NEDD4L variant; the G allele associates with reduced blood pressure ...	Blood Pressure & Hypertension	Hypertension	Moderate
rs10177833	SLC4A5	Intronic variant in the sodium bicarbonate cotransporter gene strongly associ...	Blood Pressure & Hypertension	Hypertension	Strong
rs104894135	CYP17A1 Ser106Pro	Pathogenic missense variant in CYP17A1 causing complete loss of 17α-hydroxyla...	Reproductive Hormones	Hypertension	Established
rs104894136	CYP17A1 Arg239*	Pathogenic nonsense variant in CYP17A1 introducing a premature stop codon at ...	Reproductive Hormones	Hypertension	Established
rs104894138	CYP17A1 Arg96Trp (R96W)	Pathogenic missense variant abolishing 17α-hydroxylase/17,20-lyase activity, ...	Reproductive Hormones	Hypertension	Established
rs1173771	NPR3 NPR3 promoter variant	Regulatory variant downstream of the NPR3 gene that reduces natriuretic pepti...	Blood Pressure & Hypertension	Hypertension	Strong
rs104894141	CYP17A1 W17X	Rare pathogenic nonsense variant in CYP17A1 causing complete abolition of 17α...	Reproductive Hormones	Hypertension	Established
rs12402521	PDC	Intronic PDC variant in the phosducin gene — G homozygotes show 12–15 mmHg hi...	Coronary Artery Disease & Atherosclerosis	Hypertension	Moderate
rs12606138	NEDD4L	Intronic variant in NEDD4L associated with reading ability and dyslexia susce...	Blood Pressure & Hypertension	Hypertension	Moderate
rs12917707	UMOD	Uromodulin promoter variant — strongest GWAS signal for chronic kidney diseas...	Uric Acid & Kidney Function	Hypertension	Established
rs17249754	ATP2B1	Intronic variant in the ATP2B1 calcium pump gene; the common G allele reduces...	Blood Pressure & Hypertension	Hypertension	Strong
rs1799998	CYP11B2 -344C>T	Promoter variant in aldosterone synthase increasing CYP11B2 transcription, as...	Blood Pressure & Hypertension	Hypertension	Moderate
rs2004776	AGT	Intronic regulatory variant in angiotensinogen intron I that enhances HNF3β t...	Blood Pressure & Hypertension	Hypertension	Strong
rs4293393	UMOD	UMOD promoter variant affecting uromodulin expression, linked to CKD, salt-se...	Uric Acid & Kidney Function	Hypertension	Established
rs2270915	NPR3 N521D	Missense variant in NPR3 clearance receptor disrupting Gi protein coupling, i...	Blood Pressure & Hypertension	Hypertension	Moderate
rs2681472	ATP2B1	Intronic regulatory variant near the PMCA1 calcium pump gene, one of the most...	Blood Pressure & Hypertension	Hypertension	Strong
rs1800764	ACE Promoter T>C	Upstream promoter-region ACE variant on a separate LD block from the I/D poly...	Fitness & Body	Hypertension	Moderate
rs35929607	STK39	Intronic variant in the SPAK kinase gene that has been studied for associatio...	Blood Pressure & Hypertension	Hypertension	Emerging
rs1801252	ADRB1 Ser49Gly	Beta-1 adrenergic receptor variant at position 49 affecting receptor downregu...	Fitness & Body	Hypertension	Strong
rs2881766	ESR1 ESR1 intron variant	Intronic variant in estrogen receptor alpha that has been associated with ges...	Vascular Inflammation & Remodeling	Hypertension	Moderate
rs3754777	STK39	Intronic STK39 variant that increases SPAK kinase expression, raising blood p...	Blood Pressure & Hypertension	Hypertension	Moderate
rs3755351	ADD2	Intronic variant in beta-adducin associated with hypertension susceptibility ...	Blood Pressure & Hypertension	Hypertension	Emerging
rs3865418	NEDD4L	Intronic NEDD4L variant	Blood Pressure & Hypertension	Hypertension	Moderate
rs3918226	NOS3	NOS3 promoter variant that reduces eNOS expression and increases hypertension...	Blood Pressure & Hypertension	Hypertension	Strong
rs77924615	UMOD PDILT-UMOD regulatory variant	Intronic regulatory variant physically located in PDILT that controls uromodu...	Uric Acid & Kidney Function	Hypertension	Strong
rs3093059	CRP -757T>C	Promoter variant that elevates baseline C-reactive protein levels, increasing...	Vascular Inflammation & Remodeling	Hypertension	Strong
rs4762	AGT T174M	Missense variant in angiotensinogen that increases AGT protein levels and rai...	Blood Pressure & Hypertension	Hypertension	Moderate
rs482843	CTH	Intronic CTH variant where GG homozygotes show significantly elevated preecla...	Blood Pressure & Hypertension	Hypertension	Moderate
rs4961	ADD1 Gly460Trp	Alpha-adducin missense variant that increases renal tubular sodium reabsorpti...	Blood Pressure & Hypertension	Hypertension	Strong
rs5051	AGT G-6A	Promoter variant that increases angiotensinogen gene transcription, raising p...	Blood Pressure & Hypertension	Hypertension	Strong
rs5068	NPPA	3'UTR variant that disrupts miR-425 binding, increasing atrial natriuretic pe...	Blood Pressure & Hypertension	Hypertension	Strong
rs5186	AGTR1 A1166C	3' UTR variant in angiotensin II type 1 receptor affecting blood pressure reg...	Blood Pressure & Hypertension	Hypertension	Moderate
rs7305099	WNK1 WNK1 intronic variant	Intronic WNK1 variant where the G allele is associated with increased essenti...	Blood Pressure & Hypertension	Hypertension	Moderate
rs7571842	SLC4A5	Intronic variant in the renal sodium-bicarbonate cotransporter gene SLC4A5 as...	Blood Pressure & Hypertension	Hypertension	Strong
rs841	GCH1	Intronic/3'UTR GCH1 variant tagging reduced tetrahydrobiopterin (BH4) synthes...	Blood Pressure & Hypertension	Hypertension	Moderate
rs1808593	NOS3	Intronic NOS3 variant associated with ankle-brachial index and peripheral art...	Methylation & Detox	Hypertension	Moderate
rs2758151	SGK1	Regulatory tagging SNP near SGK1 (serum/glucocorticoid regulated kinase 1) — ...	Blood Sugar & Diabetes	Hypertension	Moderate
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension	Strong
rs2297839	CHI3L1 CHI3L1 Intron Variant	Intronic variant in CHI3L1 associated with circulating YKL-40 levels and modu...	Allergy & Atopic Disease	Hypertension	Emerging
rs891512	NOS3	Intronic NOS3 variant that alters splicing factor binding and is associated w...	Methylation & Detox	Hypertension	Moderate