Tag

Immune & Autoimmune

119 genetic variants with this tag.

RSID	Gene	Description	Category
rs10208293	IL1RL1	Intronic IL1RL1 variant tagging an independent regulatory signal at the ST2 l...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs10488631	IRF5	Near-gene regulatory variant tagging an IRF5 haplotype that elevates interfer...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs10818488	TRAF1 TRAF1-C5 rheumatoid arthritis variant	Intergenic regulatory variant between TRAF1 and C5 on chromosome 9; the A all...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Strong
rs11568821	LOC105373977 PDCD1/LOC105373977 PD1.3	Intronic regulatory variant near the PDCD1 (PD-1) immune checkpoint locus tha...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs10399931	CHI3L1 CHI3L1 eQTL Partner Variant	Upstream regulatory variant in the CHI3L1 YKL-40 quantitative trait locus; th...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs10984447	DBC1 DBC1 multiple sclerosis susceptibility variant	Intronic variant in DBC1 (DBCCR1/BRINP1) at 9q33.1 associated with multiple s...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs12101255	TSHR	Intronic regulatory variant in TSHR intron 1; the T allele disrupts thymic ex...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs10954213	IRF5 3'UTR polyadenylation	3'UTR variant creating a functional polyadenylation site; A allele produces a...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs12101261	TSHR TSHR Intron 1 Adjacent Regulatory Variant	Intronic regulatory variant in TSHR intron 1 that is the primary PLZF repress...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs12188300	IL12B	Near-gene variant at the IL12B locus associated with psoriasis risk through a...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Moderate
rs11269962	IRF5 Regulatory	A 14-bp indel 2.2 kb upstream of IRF5 that is the most strongly associated ci...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Moderate
rs1217414	PTPN22	Intronic PTPN22 variant independently associated with psoriasis and ankylosin...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs12191877	HLA-C Tag for *06:02	Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Established
rs1270942	CFB	Intronic variant in Complement Factor B associated with strongly elevated sys...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs10889677	IL23R	3' UTR and intronic IL23R variant disrupting Let-7e/Let-7f miRNA binding — th...	IBD & Mucosal Immunity	Immune & Autoimmune	Strong
rs13245639	IRF5 Regulatory	Cis-regulatory IRF5 variant in near-perfect LD (r²=0.97) with the rs729302 pr...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Moderate
rs13277113	BLK	Regulatory variant upstream of BLK that reduces B-lymphoid tyrosine kinase ex...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs11052552	CLECL1	Intronic variant in CLECL1, a dendritic-cell costimulatory C-type lectin, ass...	Appetite & Obesity	Immune & Autoimmune	Moderate
rs12722489	IL2RA	Intronic variant in IL2RA intron 1 that creates an estrogen-responsive enhanc...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs1800871	IL10 -819 C>T	Promoter variant in the IL-10 haplotype system — regulates IL-10 anti-inflamm...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs1799724	TNF -857C>T	TNF promoter variant that disrupts an OCT-1 binding site, altering TNF-alpha ...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs1800896	IL10 -1082 A>G	Promoter variant affecting IL-10 production — the master anti-inflammatory cy...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs1800629	TNF -308 G>A	Promoter variant increasing TNF-alpha production approximately 2-fold, associ...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Strong
rs1883832	CD40 Kozak -1C>T	Kozak sequence variant at position −1 of the CD40 start codon — the C allele ...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs1539243	IKBKE IKBKE Ile67 synonymous variant	Synonymous coding variant in exon 4 of IKBKE (IKK-epsilon); the C allele tags...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Moderate
rs16840252	CTLA4	Upstream promoter variant (~1147 bp 5' of CTLA4) tagging an autoimmune-associ...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs1800630	TNF -863C>A	TNF promoter variant that disrupts NF-κB p50-p50 binding, reducing TNF-alpha ...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs1990760	IFIH1 Ala946Thr	Gain-of-function missense variant in the MDA5 viral RNA sensor, enhancing typ...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs115161931	CTSS	Independent CTSS-locus GWAS signal for atopic dermatitis on chromosome 1q21.3...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs12044149	IL23R	Regulatory variant upstream of the IL-23 receptor gene more strongly associat...	IBD & Mucosal Immunity	Immune & Autoimmune	Strong
rs2004640	IRF5 G198T	Intronic variant creating alternative splice site that increases type I inter...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs2248932	BLK Promoter/Intronic	Intronic BLK variant in the FAM167A-BLK regulatory locus that reduces B-lymph...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs179247	TSHR TSHR Intron 1 Graves' Disease Risk Variant	Intronic regulatory variant in TSHR intron 1; the A allele reduces thymic exp...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs2187668	HLA-DQA1 DQ2.5 tag	Tag SNP for HLA-DQ2.5 haplotype, the strongest genetic risk factor for celiac...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Established
rs2066808	IL23A	Intronic variant near IL23A encoding the IL-23 p19 subunit; G allele increase...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Strong
rs2104286	IL2RA	Intronic variant affecting IL-2 receptor alpha chain expression and soluble I...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs2736340	BLK	FAM167A-BLK region regulatory variant that reduces B-lymphoid tyrosine kinase...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs2230600	PTPN13 I1522M	Missense variant in PTPN13 (FAP-1) converting Ile to Met at position 1522; th...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs2280714	IRF5 3'UTR	Downstream regulatory variant in the IRF5 3' region that elevates IRF5 mRNA e...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Moderate
rs1495965	IL23R	Intergenic variant between IL23R and IL12RB2 on chromosome 1p31.3 associated ...	IBD & Mucosal Immunity	Immune & Autoimmune	Strong
rs2256774	IL2RA	Intronic IL2RA variant that modulates soluble IL-2RA shedding and Treg signal...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs3024491	IL10 Intronic variant	Intronic IL10 variant that reduces anti-inflammatory cytokine production, ind...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Moderate
rs11808092	EVI5	Missense variant in EVI5's coiled-coil domain altering immune cell traffickin...	Neurology & Cognition	Immune & Autoimmune	Strong
rs2268458	TSHR TSHR Intron 1 Meta-Analysis Variant	Intronic variant in TSHR intron 1; the C allele increases susceptibility to G...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs3024505	IL10 3' downstream variant	Downstream IL10 enhancer variant that disrupts a STAT3 binding site, reducing...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs12979860	IFNL4	Intronic variant in IFNL4 — the strongest host genetic predictor of hepatitis...	Pharmacogenomics	Immune & Autoimmune	Established
rs149007883	NFKBIZ NFKBIZ p.Gly102Ala	Rare protective missense variant in the NF-kB inhibitor zeta gene that reduce...	Hormones & Sleep	Immune & Autoimmune	Moderate
rs12980275	IFNL3	Downstream variant near IFNL3 — third IL28B locus predictor of hepatitis C sp...	Pharmacogenomics	Immune & Autoimmune	Established
rs2275913	IL17A -197G>A	Promoter variant in the NFAT binding site that increases IL-17A transcription...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Strong
rs231775	CTLA4 Thr17Ala	Missense variant in the CTLA-4 leader peptide that reduces surface expression...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs3131379	MSH5	Intronic variant in the HLA class III region near MSH5 associated with lupus ...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs3748079	ITPR3 ITPR3 rs3748079	Promoter variant in the ITPR3 calcium channel gene affecting NKX2.5 binding a...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Moderate
rs231806	CTLA4	Upstream regulatory variant in the CTLA4 MH30 region associated with latent a...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Emerging
rs2469434	CD226	Deep-intronic variant in the CD226 (DNAM-1) co-stimulatory receptor gene asso...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs4728142	IRF5 Promoter Indel Tag (CGGGG insertion)	Enhancer variant ~5 kb upstream of IRF5 that promotes ZBTB3-mediated chromati...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Vascular Inflammation & Remodeling	Immune & Autoimmune	Strong
rs3212227	IL12B 3'UTR	IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Strong
rs4810485	CD40	Intronic variant in CD40 regulating B-cell surface expression; the G allele d...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Strong
rs3213094	IL12B Promoter-region	Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Moderate
rs4840568	BLK	Regulatory variant 2kb upstream of BLK that tags reduced B-lymphoid tyrosine ...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Moderate
rs6910071	TSBP1	MHC-region intronic variant tagging HLA-DRB1 shared epitope haplotypes; G all...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs3087243	CTLA4 CT60	Immune checkpoint regulatory variant in the 3'UTR affecting T-cell activation...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs729302	IRF5	Near-gene variant tagging an IRF5 protective haplotype in the 5' promoter reg...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs3134883	IL2RA	Intronic IL2RA variant independently associated with rheumatoid arthritis ris...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs7454108	HLA-DQB1 DQ8 tag	Tag SNP identifying HLA-DQ8 haplotype, second strongest genetic risk factor f...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Established
rs2301436	FGFR1OP	Intronic variant in FGFR1OP (CEP43) at the RNASET2-FGFR1OP-CCR6 autoimmune su...	IBD & Mucosal Immunity	Immune & Autoimmune	Strong
rs33996649	PTPN22 R263Q	Protective loss-of-function variant in the PTPN22 catalytic domain that reduc...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs55687265	ATP8B4 ATP8B4 Phospholipid Flippase F436L	Missense variant in ATP8B4 converting phenylalanine to leucine at position 43...	B-Cell Immunity & Antibody-Mediated Disease	Immune & Autoimmune	Moderate
rs7514229	TNFSF4 TNFSF4 OX40 ligand variant	Intronic variant in TNFSF4 that tags an upstream regulatory haplotype associa...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Moderate
rs3748067	IL17A	3'UTR variant in IL-17A that alters post-transcriptional regulation via miRNA...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs3761847	TRAF1	Intronic GWAS variant in the TRAF1-C5 locus on chromosome 9 robustly associat...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Strong
rs3789604	RSBN1	Synonymous RSBN1 variant that tags a PTPN22 locus haplotype independently ass...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs3796508	TLR6 Val327Met	Missense variant substituting valine with methionine at position 327 of TLR6,...	Innate Immunity & Infection Defense	Immune & Autoimmune	Emerging
rs41295061	IL2RA	Regulatory variant in the IL2RA locus altering LEF1 transcription factor bind...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs582757	TNFAIP3 TNFAIP3 A20 regulatory variant	Intronic regulatory variant in TNFAIP3 — the primary NF-kB brake gene — with ...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Strong
rs9268839	HLA-DRA	Intergenic tag SNP upstream of HLA-DRA; the G allele is the primary GWAS sign...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs13424006	IL1RL1	Intronic IL1RL1 variant in the 10th intron of the ST2 receptor gene; C allele...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs3890745	MMEL1 MMEL1 rs3890745	Intronic variant near MMEL1 and TNFRSF14 on chromosome 1p36; the C allele is ...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Strong
rs559406	PTPN2	Intronic PTPN2 variant whose G allele reduces T-cell protein tyrosine phospha...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs9277535	HLA-DPB1	3' UTR eQTL that reduces HLA-DPB1 expression, impairing antigen presentation ...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs5742909	CTLA4 Promoter -318C/T	Promoter variant that increases CTLA-4 transcription; T allele carriers show ...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Moderate
rs9378815	IRF4	Regulatory variant ~15 kb upstream of IRF4 that modulates germinal center B c...	Interferon Signaling & Systemic Autoimmune	Immune & Autoimmune	Strong
rs146527530	CTSS CTSS AD Risk Signal (Budu-Aggrey 2023)	Third independent CTSS-locus atopic dermatitis risk signal from the Budu-Aggr...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs6887695	IL12B Upstream regulatory	Upstream regulatory variant ~60 kb 5' of IL12B, forming the canonical two-SNP...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Strong
rs17696736	NAA25 NAA25 G/A	Intronic tag SNP at the 12q24 locus that captures SH2B3/LNK regulatory variat...	Blood Sugar & Diabetes	Immune & Autoimmune	Strong
rs72634030	RABEP1	Intronic RABEP1 variant associated with rheumatoid arthritis risk, acting thr...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Emerging
rs7540214	IFNLR1 IFNLR1 variant	Intronic variant in the interferon lambda receptor 1 gene that elevates PsA r...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Moderate
rs763361	CD226 Gly307Ser	Missense variant in the T-cell and NK-cell co-stimulatory receptor CD226 (DNA...	Autoimmune Tolerance & T-Cell Regulation	Immune & Autoimmune	Strong
rs7746808	IL23A	Intergenic variant near the IL23A locus associated with psoriasis and psoriat...	Psoriasis & Spondyloarthropathy	Immune & Autoimmune	Emerging
rs6693831	IL23R	Intronic IL23R variant where the minor T allele is associated with increased ...	IBD & Mucosal Immunity	Immune & Autoimmune	Moderate
rs763780	IL17F His161Arg	Missense variant that reduces IL-17F bioactivity and acts as a natural IL-17F...	TNF, NF-kB & Inflammatory Cytokines	Immune & Autoimmune	Moderate
rs1800693	TNFRSF1A	Splice-region variant in TNFR1 that generates a soluble Δ6 isoform mimicking ...	Neurology & Cognition	Immune & Autoimmune	Strong
rs7530511	IL23R Leu310Pro	Missense variant in the IL-23 receptor that substitutes leucine for proline a...	IBD & Mucosal Immunity	Immune & Autoimmune	Moderate
rs7091565	ANXA11 ANXA11 rs7091565	3' UTR variant in ANXA11 (annexin A11) in strong LD with the functional R230C...	Innate Immunity & Infection Defense	Immune & Autoimmune	Moderate
rs1950897	RAD51B RAD51B Intronic RA Susceptibility Variant	Intronic variant in RAD51B on chromosome 14; the T allele is associated with ...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs2040410	HLA-DQA1 HLA-DQ Autoimmune Tag SNP	Intronic tag SNP near HLA-DQA1 that marks the DR3 (DRB10301-DQA10501-DQB1*0...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs2523506	DDX39B	Regulatory variant in the 5' UTR of DDX39B (RNA helicase/mRNA export factor) ...	Neurology & Cognition	Immune & Autoimmune	Strong
rs2227284	IL4 IL4 T+2979G	Intronic regulatory variant in IL-4, the master Th2 cytokine; the T allele im...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs2240032	RAD50 RAD50 RHS7 TH2-LCR Variant	Intronic RAD50 variant in the Th2 locus control region (RHS7); T allele alter...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs3129934	HLA-DRB5 DR15 haplotype tag	Tag SNP for HLA-DRB5*01:01 on the DR15 susceptibility haplotype, physically n...	Neurology & Cognition	Immune & Autoimmune	Strong
rs2243250	IL4 IL4 -589C>T	Promoter polymorphism 589 bases upstream of the IL-4 transcription start site...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs3135388	HLA-DRA Tag for DRB1*15:01	Tag SNP for HLA-DRB1*15:01 (physically located near HLA-DRA), the strongest g...	Neurology & Cognition	Immune & Autoimmune	Established
rs2243290	IL4 IL4 Intron 3 Protective Haplotype Variant	Intronic IL4 variant that forms part of the protective C-G-C haplotype (rs224...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs3194051	IL7R I356V	Exon 8 missense variant in the IL-7 receptor alpha chain (Ile356Val) associat...	Neurology & Cognition	Immune & Autoimmune	Moderate
rs4149584	TNFRSF1A R92Q	Missense variant in TNF receptor 1 that causes low-penetrance TRAPS (recurren...	Neurology & Cognition	Immune & Autoimmune	Strong
rs4803217	IFNL3 3'UTR	3' untranslated region variant in IFNL3 (IL28B) that controls mRNA stability ...	Pharmacogenomics	Immune & Autoimmune	Strong
rs78534766	ADCY7 ADCY7 D439E	Low-frequency missense variant in adenylyl cyclase 7 that reduces cAMP synthe...	Hormones & Sleep	Immune & Autoimmune	Strong
rs4950928	CHI3L1 YKL-40 Promoter Variant (-131C>G)	Promoter variant controlling YKL-40 (chitinase 3-like 1) expression; the comm...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs6062486	RTEL1 Telomere helicase immune variant	Intronic variant in RTEL1 (regulator of telomere elongation helicase 1) assoc...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs6589702	PRG2 PRG2 Eosinophil Major Basic Protein Variant	Intergenic regulatory variant near the PRG2/PRG3 eosinophil granule protein c...	Allergy & Atopic Disease	Immune & Autoimmune	Emerging
rs7125552	EMSY EMSY Haplotype Partner Allergy Variant	Intronic EMSY variant that defines the high-risk haplotype at 11q13.5; the G ...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs7130588	LRRC32	Regulatory variant near LRRC32 (GARP) on chromosome 11q13.5; the G allele inc...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs7927894	EMSY	Regulatory variant near the EMSY/C11orf30 locus; T allele increases EMSY expr...	Allergy & Atopic Disease	Immune & Autoimmune	Strong
rs6897932	IL7R T244I	Splicing variant in the IL-7 receptor alpha chain that shifts the balance tow...	Neurology & Cognition	Immune & Autoimmune	Strong
rs872129	CHI3L1 CHI3L1 eQTL Variant	Third independent eQTL signal at the CHI3L1/YKL-40 locus on chromosome 1q32.1...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs911263	RAD51B RAD51B RA Proxy Variant	Intronic proxy variant in RAD51B associated with seropositive rheumatoid arth...	Allergy & Atopic Disease	Immune & Autoimmune	Moderate
rs8099917	IFNL3	Intergenic variant upstream of IFNL3 — second major IL28B locus predictor of ...	Pharmacogenomics	Immune & Autoimmune	Established
rs9271366	HLA-DQA1 eQTL	Intergenic eQTL near HLA-DQA1 that tags the DR15 haplotype (DRB115:01/DQA10...	Neurology & Cognition	Immune & Autoimmune	Established
rs9275328	HLA-DQB1 DQB1 region	Intergenic SNP between HLA-DQB1 and HLA-DQA2 that tags the DQB1*06:02 allele,...	Neurology & Cognition	Immune & Autoimmune	Strong