Tag

Neurological Risk

15 genetic variants with this tag.

RSID	Gene	Description	Category
rs744373	BIN1	Second strongest genetic risk factor for Alzheimer's disease after APOE, asso...	Brain & Mental Health	Alzheimer's Neurological Risk Memory	Established
rs11136000	CLU	Intronic variant in clusterin gene affecting Alzheimer's disease risk through...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Brain & Mental Health	Alzheimer's Neurological Risk Neuroinflammation	Established
rs3851179	PICALM	Variant in the PICALM gene affecting amyloid-beta clearance across the blood-...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs17649553	MAPT H1/H2 Haplotype Tag	Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs76904798	LRRK2 5' Regulatory Variant	Common noncoding variant upstream of LRRK2 that increases gene expression in ...	Brain & Mental Health	Parkinson's Neurological Risk Brain Health	Strong
rs6897932	IL7R T244I	A missense variant in the IL-7 receptor alpha chain that increases soluble IL...	Immune & Gut	Immune & Autoimmune Multiple Sclerosis T-Cell Regulation	Strong
rs356219	SNCA	SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs1800547	MAPT H1/H2 Haplotype Splice Regulator	Intronic MAPT variant that regulates tau exon 3 splicing via hnRNP F/Q bindin...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs242557	MAPT H1c Sub-haplotype Tag	Intronic MAPT variant tagging the H1c sub-haplotype within the H1 clade, inde...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs2736990	SNCA	Intronic SNCA variant (intron 4) associated with Parkinson's disease risk and...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs11931074	SNCA	SNCA 3′-region variant in the extended 3′ UTR that affects alpha-synuclein mR...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs2471738	MAPT H1c Sub-haplotype Tag (rs2471738)	Intronic MAPT variant whose T allele co-defines the H1c sub-haplotype, indepe...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs17651213	MAPT Exon 3 Splice Regulator	Intronic MAPT variant that directly regulates tau exon 3 splicing via differe...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong