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rs2738058
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DEFA1A3
|
Intergenic variant downstream of the DEFA1A3 alpha-defensin locus; T risk all...
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Dental & Oral Health
|
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Strong
|
|
rs2066844
|
NOD2
R702W
|
Missense variant in the NOD2 gene that increases Crohn's disease risk, partic...
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Immune & Gut
|
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Established
|
|
rs3197999
|
MST1
R689C
|
Macrophage-stimulating protein variant affecting innate immune response and I...
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Immune & Gut
|
|
Strong
|
|
rs35829419
|
NLRP3
Q705K
|
Gain-of-function missense variant in the NLRP3 inflammasome sensor that eleva...
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Immune & Gut
|
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Moderate
|
|
rs2569190
|
CD14
-159C>T
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Promoter variant affecting CD14 expression and LPS receptor signaling — deter...
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Immune & Gut
|
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Strong
|
|
rs1800450
|
MBL2
Gly54Asp (variant B)
|
Missense variant disrupting mannose-binding lectin oligomerization, reducing ...
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Immune & Gut
|
|
Strong
|
|
rs4077515
|
CARD9
S12N
|
Gain-of-function missense variant in the CARD9 adaptor protein that enhances ...
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Immune & Gut
|
|
Strong
|
|
rs396991
|
FCGR3A
V158F
|
Missense variant in Fc gamma receptor IIIa (CD16a) that determines NK cell Ig...
|
Immune & Gut
|
|
Strong
|
|
rs11362
|
DEFB1
G-20A
|
5' UTR variant in the beta-defensin 1 gene that reduces antimicrobial peptide...
|
Immune & Gut
|
|
Moderate
|
|
rs1990760
|
IFIH1
Ala946Thr
|
Gain-of-function missense variant in the MDA5 viral RNA sensor, enhancing typ...
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Immune & Gut
|
|
Strong
|
|
rs5743708
|
TLR2
R753Q
|
Missense variant in Toll-Like Receptor 2 impairing innate immune signaling to...
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Immune & Gut
|
|
Strong
|
|
rs12979860
|
IFNL4
|
Intronic variant in IFNL4 — the strongest host genetic predictor of hepatitis...
|
Immune & Gut
|
|
Established
|
|
rs117648444
|
IFNL4
Pro70Ser (P70S)
|
Missense variant in IFNL4 exon 2 that reduces IFN-λ4 protein activity; the Se...
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Immune & Gut
|
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Strong
|