Tag

Insulin Resistance

97 genetic variants with this tag.

RSID	Gene	Description	Category
rs1000940	RABEP1 RABEP1 Metabolic-Immune Regulatory Variant	Intronic variant in RABEP1 associated with fasting glucose modulation under p...	Autoimmune Tolerance & T-Cell Regulation	Insulin Resistance	Emerging
rs1044471	ADIPOR2 ADIPOR2 3'UTR variant	A common 3'UTR variant in the liver-expressed adiponectin receptor 2 gene; th...	Fat Storage & Energy	Insulin Resistance	Moderate
rs1058322	ADIPOR2	Intronic ADIPOR2 variant whose T allele reduces receptor expression in immune...	Fat Storage & Energy	Insulin Resistance	Moderate
rs10739076	PLGRKT PLGRKT Plasminogen Receptor/Fibrinolysis	Intergenic PCOS susceptibility locus downstream of PLGRKT (plasminogen recept...	Fertility & Ovarian Function	Insulin Resistance	Moderate
rs1063537	ADIPOQ	3'UTR variant in ADIPOQ that modulates adiponectin mRNA stability; the common...	Fat Storage & Energy	Insulin Resistance	Moderate
rs1044498	ENPP1 K121Q	ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs10848554	ADIPOR2	Intronic ADIPOR2 variant co-associated with cardiovascular disease risk in in...	Fat Storage & Energy	Insulin Resistance	Moderate
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Appetite & Obesity	Insulin Resistance	Strong
rs10882283	RBP4 RBP4 rs10882283	5' UTR variant in RBP4 that influences expression of retinol binding protein ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs11037909	EXT2	Intronic EXT2 variant associated with a modest increase in type 2 diabetes su...	Appetite & Obesity	Insulin Resistance	Moderate
rs11061937	ADIPOR2 ADIPOR2 rs11061937	Intronic ADIPOR2 variant associated with cardiovascular disease risk in indiv...	Fat Storage & Energy	Insulin Resistance	Moderate
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Insulin Resistance	Moderate
rs11061946	ADIPOR2	Intronic variant in the adiponectin receptor 2 gene; rare homozygotes showed ...	Fat Storage & Energy	Insulin Resistance	Emerging
rs12478601	THADA THADA PCOS/Insulin Resistance	Intronic variant in THADA (thyroid adenoma associated) on chromosome 2p21; th...	Fertility & Ovarian Function	Insulin Resistance	Strong
rs1151996	PPARG PPARG rs1151996	Intronic PPARG variant significantly associated with circulating vitamin D le...	Fat Storage & Energy	Insulin Resistance	Moderate
rs1152003	PPARG	PPARG 3'-flanking region variant — the G allele independently tags a PPARG re...	Fat Storage & Energy	Insulin Resistance	Emerging
rs12970134	MC4R MC4R region variant	Near-gene variant ~188kb downstream of MC4R associated with increased waist c...	Appetite & Obesity	Insulin Resistance	Strong
rs2972164	PPARG	Intronic PPARG variant associated with rate of change in insulin sensitivity ...	Liver Fat	Insulin Resistance	Moderate
rs10885406	TCF7L2 TCF7L2 Wnt Signaling Depth Variant	Intronic TCF7L2 variant tagging the diabetes-risk haplotype and associated wi...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs11590235	SKI	TGF-beta signaling regulator variant identified as the top shared locus betwe...	Cardiomyopathy & Structural Heart	Insulin Resistance	Moderate
rs116862713	PRKAB1	Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig...	Fat Storage & Energy	Insulin Resistance	Emerging
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	Insulin Resistance	Moderate
rs10954640	ENPP1 ENPP1 3'UTR Variant	Intergenic variant near ENPP1-associated regulatory loci; T allele is associa...	Blood Sugar & Diabetes	Insulin Resistance	Emerging
rs1143699	PTPRS PTPRS C/T (rs1143699)	Synonymous PTPRS variant associated with increased type 2 diabetes risk in me...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs11558471	SLC30A8 SLC30A8 Zinc Transport Depth Variant	3-prime UTR variant in the SLC30A8 zinc transporter gene that alters ZnT8 mRN...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs11868035	SREBF1	SREBF1 intronic/3'UTR variant affecting SREBP-1c expression, associated with ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs2271194	ERBB3 ERBB3/RAB5B PCOS Metabolic	A splice-region variant at the ERBB3/RAB5B locus on chromosome 12q13.2, a rep...	Fertility & Ovarian Function	Insulin Resistance	Strong
rs11705701	IGF2BP2 IGF2BP2 Insulin Signaling Variant	Upstream regulatory variant in IGF2BP2 that shifts mRNA isoform balance in ad...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs12490265	PPARG PPARG Intronic Haplotype Variant	Intronic PPARG variant in a metabolic syndrome–associated haplotype block; th...	Fat Storage & Energy	Insulin Resistance	Emerging
rs12243326	TCF7L2 TCF7L2 Incretin Response Depth Variant	Intronic TCF7L2 depth variant replicated across multiple populations as a sec...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs12636454	PPARG PPARG rs12636454	Intronic PPARG variant associated with modest reduction in type 2 diabetes ri...	Fat Storage & Energy	Insulin Resistance	Emerging
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Insulin Resistance	Moderate
rs12610022	INSR	Intronic INSR variant that may alter insulin receptor expression or isoform b...	Blood Sugar & Diabetes	Insulin Resistance	Emerging
rs16861194	ADIPOQ -11426A>G	Upstream promoter variant that reduces ADIPOQ transcription, lowering circula...	Fat Storage & Energy	Insulin Resistance	Moderate
rs16861205	ADIPOQ	Intronic ADIPOQ variant in LD with the promoter region; the minor A allele is...	Fat Storage & Energy	Insulin Resistance	Moderate
rs2943634	IRS1	Intergenic variant near IRS1 at 2q36.3 associated with ischemic stroke risk, ...	Coronary Artery Disease & Atherosclerosis	Insulin Resistance	Moderate
rs4784165	TOX3 TOX3 rs4784165	Intronic PCOS susceptibility variant near TOX3; the G allele is associated wi...	Fertility & Ovarian Function	Insulin Resistance	Moderate
rs16928751	ADIPOR2 ADIPOR2 CVD co-association variant	Synonymous coding variant in ADIPOR2 (Q265Q) that was co-associated with card...	Fat Storage & Energy	Insulin Resistance	Emerging
rs17036314	PPARG	Intronic PPARG variant — carriers of the C allele have elevated fasting gluco...	Fat Storage & Energy	Insulin Resistance	Moderate
rs476828	MC4R MC4R-region BMI variant	Intergenic variant in the MC4R regulatory haplotype block, tagging the same a...	Appetite & Obesity	Insulin Resistance	Strong
rs1495377	TSPAN8	Intronic variant in TSPAN8 (Tetraspanin 8) associated with reduced insulin se...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs2197076	FABP1	Intronic FABP1 variant associated with type 2 diabetes risk and insulin resis...	Triglycerides & Fatty Acids	Insulin Resistance	Moderate
rs16989673	PTPN1 1484insG	A guanine duplication in the 3'-UTR of PTPN1 (PTP1B) that increases mRNA stab...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs182052	ADIPOQ ADIPOQ promoter -10066A>G	Intronic/promoter-region ADIPOQ variant where the A allele reduces circulatin...	Fat Storage & Energy	Insulin Resistance	Strong
rs1862513	RETN -420C>G	Promoter variant that increases resistin expression via Sp1/Sp3 transcription...	Fat Storage & Energy	Insulin Resistance	Moderate
rs1799817	INSR His1085His	Synonymous variant in the tyrosine kinase domain of the insulin receptor; the...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs2241767	ADIPOQ +349A>G	Intronic variant in the adiponectin gene associated with lower circulating ad...	Fat Storage & Energy	Insulin Resistance	Moderate
rs858518	SHBG SHBG intronic regulatory variant	Intronic variant within the SHBG gene that participates in a haplotype (with ...	Reproductive Hormones	Insulin Resistance	Moderate
rs1799999	PPP1R3A Asp905Tyr	Missense variant in the skeletal muscle glycogen-targeting subunit of protein...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs2279525	PPARGC1A PPARGC1A 3' UTR metabolic association variant	3' UTR variant in the PGC-1alpha gene that may alter PPARGC1A mRNA stability ...	Fat Storage & Energy	Insulin Resistance	Emerging
rs1800961	HNF4A Thr130Ile	Missense variant in HNF4A causing hepatocyte-specific loss of transcriptional...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs2297508	SREBF1 SREBF1 G952G	SREBF1 3' UTR variant that subtly impairs SREBP-1c function, increasing risk ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Appetite & Obesity	Insulin Resistance	Strong
rs1801278	IRS1 Gly972Arg (G972R)	Missense variant in insulin receptor substrate 1 that impairs tyrosine phosph...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs7359397	SH2B1 SH2B1 C/T	Regulatory CpG-SNP downstream of SH2B1 that reduces gene expression via allel...	Appetite & Obesity	Insulin Resistance	Moderate
rs2854117	APOC3 APOC3 C-482T	Promoter variant in APOC3 disrupting insulin-responsive regulation of apolipo...	Triglycerides & Fatty Acids	Insulin Resistance	Moderate
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Appetite & Obesity	Insulin Resistance	Strong
rs2059807	INSR INSR intronic variant	Intronic INSR variant associated with PCOS susceptibility and metabolic syndr...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs2229431	INSR	Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee...	Blood Sugar & Diabetes	Insulin Resistance	Emerging
rs2920502	PPARG PPARG rs2920502	Intronic PPARG variant associated with body fat percentage, impaired glucose ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs2233580	PAX4 Arg192His	Missense variant that impairs PAX4's ability to repress insulin and glucagon ...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Appetite & Obesity	Insulin Resistance	Moderate
rs2237886	KCNQ1 KCNQ1 Potassium Channel Diabetes Variant	Intronic variant in KCNQ1's imprinted region, tagging the same LD block as es...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs3758391	SIRT1	Promoter-region variant in SIRT1 affecting deacetylase expression; T allele e...	Longevity & Aging	Insulin Resistance	Moderate
rs3734254	PPARD T+294C	PPARD 3'UTR variant that reduces fatty acid oxidation capacity and blunts the...	Fat Storage & Energy	Insulin Resistance	Moderate
rs2295490	TRIB3 Q84R	TRIB3 pseudokinase missense variant that increases Akt inhibition, impairing ...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs3745012	LPIN2 LPIN2 3'UTR variant	3' UTR regulatory variant in LPIN2 (lipin 2) that alters fat distribution and...	Fat Storage & Energy	Insulin Resistance	Moderate
rs2466293	SLC30A8 SLC30A8 Islet Zinc Regulation Variant	3'UTR variant in the zinc transporter ZnT8 gene that disrupts miRNA binding s...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs3774261	ADIPOQ ADIPOQ rs3774261	Intronic ADIPOQ variant that reduces circulating adiponectin levels in G alle...	Fat Storage & Energy	Insulin Resistance	Moderate
rs3856806	PPARG His477His (C1431T)	Synonymous PPARG variant where the T allele reduces type 2 diabetes risk and ...	Fat Storage & Energy	Insulin Resistance	Strong
rs4684847	PPARG PPARG cis-regulatory variant (PR domain recruitment)	Intronic cis-regulatory PPARG variant where the C allele recruits PR domain r...	Fat Storage & Energy	Insulin Resistance	Moderate
rs3487348	PTPN1 PTPN1 LD Block Co-Variant	Intronic PTPN1 variant in the 100-kb haplotype block; T allele associated wit...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs4684854	PPARG	Intergenic regulatory variant downstream of PPARG associated with central obe...	Fat Storage & Energy	Insulin Resistance	Emerging
rs367643250	DYRK1B R102C	Rare gain-of-function variant causing autosomal dominant metabolic syndrome (...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs659366	UCP2	Promoter variant at position -866 of UCP2 that controls mitochondrial uncoupl...	Longevity & Aging	Insulin Resistance	Moderate
rs3787345	PTPN1 PTPN1 LD Block Co-Variant	Intronic PTPN1 tag SNP within the 100-kb PTP1B insulin-resistance haplotype b...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs3787348	PTPN1 PTPN1 intronic variant	Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs4783244	CDH13	Intronic CDH13 variant altering T-cadherin expression; T allele carriers have...	Triglycerides & Fatty Acids	Insulin Resistance	Strong
rs6809631	PPARG	Intronic PPARG promoter tagSNP associated with modest reduction in type 2 dia...	Fat Storage & Energy	Insulin Resistance	Emerging
rs4807015	PTPRS PTPRS T2D risk variant	Intronic PTPRS variant that tags elevated type 2 diabetes risk in both sexes ...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs6981587	ANK1 ANK1 small-ankyrin T2D locus variant	Intronic ANK1 variant at the NKX6-3/ANK1 type 2 diabetes locus; the T allele ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs8192678	PPARGC1A Gly482Ser	Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha...	Longevity & Aging	Insulin Resistance	Strong
rs4812829	HNF4A HNF4A Intronic T2D Risk Variant	Common intronic variant in HNF4A associated with modestly elevated type 2 dia...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs767870	ADIPOR2 ADIPOR2 intron 6 variant	Intronic variant in ADIPOR2 (adiponectin receptor 2) associated with reduced ...	Fat Storage & Energy	Insulin Resistance	Moderate
rs822391	ADIPOQ IVS1+407C>T	Intronic variant in the adiponectin gene associated with circulating adiponec...	Fat Storage & Energy	Insulin Resistance	Moderate
rs9491696	RSPO3	Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt...	Fat Storage & Energy	Insulin Resistance	Strong
rs9817428	PPARG PPARG promoter tagSNP	Intronic PPARG tagSNP with cross-ethnic replication for type 2 diabetes risk ...	Fat Storage & Energy	Insulin Resistance	Emerging
rs587777380	DYRK1B H90P / H90R	Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the D...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs6020611	PTPN1	Intronic PTPN1 tag SNP in the PTP1B regulatory LD block; the minor A allele i...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs6031551	HNF4A HNF4A Regulatory Variant	Intronic variant 80 bp from rs6031552 within the HNF4A P2 promoter haplotype ...	Blood Sugar & Diabetes	Insulin Resistance	Emerging
rs6067484	PTPN1 PTPN1 rs6067484	Intronic PTPN1 tag SNP within the 100-kb T2D-risk haplotype block — carriers ...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs653178	SH2B3 ATXN2/SH2B3 12q24 pleiotropic locus	Pleiotropic 12q24 locus variant in SH2B3 (LNK) modulating JAK-STAT cytokine s...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs6815001	SLC2A9 SLC2A9 Renal Urate Clearance Variant	Intronic variant in the major renal urate transporter; the G allele tags a ha...	Blood Sugar & Diabetes	Insulin Resistance	Strong
rs780095	GCKR GCKR Glucose-Lipid Regulation Variant	Intronic GCKR enhancer variant on the CGG regulatory haplotype; the G allele ...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs914458	PTPN1 PTPN1 downstream variant	Downstream regulatory variant 10 kb 3' of PTPN1 (PTP1B) associated with type ...	Blood Sugar & Diabetes	Insulin Resistance	Emerging
rs9402571	SGK1	Regulatory variant in SGK1 (serum/glucocorticoid regulated kinase 1) — the mi...	Blood Sugar & Diabetes	Insulin Resistance	Moderate
rs941798	PTPN1	Intronic PTPN1 variant tagging a haplotype block associated with reduced insu...	Blood Sugar & Diabetes	Insulin Resistance	Moderate