Tag
Insulin Resistance
62 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1000940 | RABEP1 RABEP1 Metabolic-Immune Regulatory Variant | Intronic variant in RABEP1 associated with fasting glucose modulation under p... | Autoimmune Tolerance & T-Cell Regulation | Emerging | |
| rs1044471 | ADIPOR2 ADIPOR2 3'UTR variant | A common 3'UTR variant in the liver-expressed adiponectin receptor 2 gene; th... | Fat Storage & Energy | Moderate | |
| rs1058322 | ADIPOR2 | Intronic ADIPOR2 variant whose T allele reduces receptor expression in immune... | Fat Storage & Energy | Moderate | |
| rs10882283 | RBP4 RBP4 rs10882283 | 5' UTR variant in RBP4 that influences expression of retinol binding protein ... | Fat Storage & Energy | Moderate | |
| rs1044498 | ENPP1 K121Q | ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece... | Blood Sugar & Diabetes | Strong | |
| rs10938397 | GNPDA2 | GIANT consortium GWAS obesity locus near GNPDA2 | Appetite & Obesity | Strong | |
| rs11061946 | ADIPOR2 | Intronic variant in the adiponectin receptor 2 gene; rare homozygotes showed ... | Fat Storage & Energy | Emerging | |
| rs1137101 | LEPR Q223R (Gln223Arg) | Common leptin receptor variant in the leptin-binding domain affecting satiety... | Hormones & Sleep | Moderate | |
| rs116862713 | PRKAB1 | Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig... | Fat Storage & Energy | Emerging | |
| rs12478601 | THADA THADA PCOS/Insulin Resistance | Intronic variant in THADA (thyroid adenoma associated) on chromosome 2p21; th... | Fertility & Ovarian Function | Strong | |
| rs12490265 | PPARG PPARG Intronic Haplotype Variant | Intronic PPARG variant in a metabolic syndrome–associated haplotype block; th... | Fat Storage & Energy | Emerging | |
| rs12970134 | MC4R MC4R region variant | Near-gene variant ~188kb downstream of MC4R associated with increased waist c... | Appetite & Obesity | Strong | |
| rs2972164 | PPARG | Intronic PPARG variant associated with rate of change in insulin sensitivity ... | Liver Fat | Moderate | |
| rs11590235 | SKI | TGF-beta signaling regulator variant identified as the top shared locus betwe... | Cardiomyopathy & Structural Heart | Moderate | |
| rs10885406 | TCF7L2 TCF7L2 Wnt Signaling Depth Variant | Intronic TCF7L2 variant tagging the diabetes-risk haplotype and associated wi... | Blood Sugar & Diabetes | Moderate | |
| rs12086634 | HSD11B1 Intron 3 variant | Modulates local cortisol activation from cortisone in liver and adipose tissu... | Hormones & Sleep | Moderate | |
| rs16861194 | ADIPOQ -11426A>G | Upstream promoter variant that reduces ADIPOQ transcription, lowering circula... | Fat Storage & Energy | Moderate | |
| rs16861205 | ADIPOQ | Intronic ADIPOQ variant in LD with the promoter region; the minor A allele is... | Fat Storage & Energy | Moderate | |
| rs11558471 | SLC30A8 SLC30A8 Zinc Transport Depth Variant | 3-prime UTR variant in the SLC30A8 zinc transporter gene that alters ZnT8 mRN... | Blood Sugar & Diabetes | Strong | |
| rs16928751 | ADIPOR2 ADIPOR2 CVD co-association variant | Synonymous coding variant in ADIPOR2 (Q265Q) that was co-associated with card... | Fat Storage & Energy | Emerging | |
| rs11705701 | IGF2BP2 IGF2BP2 Insulin Signaling Variant | Upstream regulatory variant in IGF2BP2 that shifts mRNA isoform balance in ad... | Blood Sugar & Diabetes | Moderate | |
| rs182052 | ADIPOQ ADIPOQ promoter -10066A>G | Intronic/promoter-region ADIPOQ variant where the A allele reduces circulatin... | Fat Storage & Energy | Strong | |
| rs12243326 | TCF7L2 TCF7L2 Incretin Response Depth Variant | Intronic TCF7L2 depth variant replicated across multiple populations as a sec... | Blood Sugar & Diabetes | Moderate | |
| rs1805097 | IRS2 Gly1057Asp | Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ... | Longevity & Aging | Moderate | |
| rs476828 | MC4R MC4R-region BMI variant | Intergenic variant in the MC4R regulatory haplotype block, tagging the same a... | Appetite & Obesity | Strong | |
| rs12610022 | INSR | Intronic INSR variant that may alter insulin receptor expression or isoform b... | Blood Sugar & Diabetes | Emerging | |
| rs3734254 | PPARD T+294C | PPARD 3'UTR variant that reduces fatty acid oxidation capacity and blunts the... | Fat Storage & Energy | Moderate | |
| rs4784165 | TOX3 TOX3 rs4784165 | Intronic PCOS susceptibility variant near TOX3; the G allele is associated wi... | Fertility & Ovarian Function | Moderate | |
| rs3745012 | LPIN2 LPIN2 3'UTR variant | 3' UTR regulatory variant in LPIN2 (lipin 2) that alters fat distribution and... | Fat Storage & Energy | Moderate | |
| rs1799817 | INSR His1085His | Synonymous variant in the tyrosine kinase domain of the insulin receptor; the... | Blood Sugar & Diabetes | Moderate | |
| rs3774261 | ADIPOQ ADIPOQ rs3774261 | Intronic ADIPOQ variant that reduces circulating adiponectin levels in G alle... | Fat Storage & Energy | Moderate | |
| rs6548238 | TMEM18 | Second strongest obesity GWAS locus after FTO | Appetite & Obesity | Strong | |
| rs1799999 | PPP1R3A Asp905Tyr | Missense variant in the skeletal muscle glycogen-targeting subunit of protein... | Blood Sugar & Diabetes | Moderate | |
| rs1800961 | HNF4A Thr130Ile | Missense variant in HNF4A causing hepatocyte-specific loss of transcriptional... | Blood Sugar & Diabetes | Moderate | |
| rs3856806 | PPARG His477His (C1431T) | Synonymous PPARG variant where the T allele reduces type 2 diabetes risk and ... | Fat Storage & Energy | Strong | |
| rs7498665 | SH2B1 Thr484Ala | Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr... | Appetite & Obesity | Strong | |
| rs1801278 | IRS1 Gly972Arg (G972R) | Missense variant in insulin receptor substrate 1 that impairs tyrosine phosph... | Blood Sugar & Diabetes | Strong | |
| rs2197076 | FABP1 | Intronic FABP1 variant associated with type 2 diabetes risk and insulin resis... | Triglycerides & Fatty Acids | Moderate | |
| rs767870 | ADIPOR2 ADIPOR2 intron 6 variant | Intronic variant in ADIPOR2 (adiponectin receptor 2) associated with reduced ... | Fat Storage & Energy | Moderate | |
| rs2059807 | INSR INSR intronic variant | Intronic INSR variant associated with PCOS susceptibility and metabolic syndr... | Blood Sugar & Diabetes | Moderate | |
| rs7799039 | LEP G-2548A | Promoter variant that increases leptin gene expression in adipose tissue, ele... | Appetite & Obesity | Moderate | |
| rs822391 | ADIPOQ IVS1+407C>T | Intronic variant in the adiponectin gene associated with ischemic stroke risk... | Fat Storage & Energy | Moderate | |
| rs2229431 | INSR | Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee... | Blood Sugar & Diabetes | Emerging | |
| rs2233580 | PAX4 Arg192His | Missense variant that impairs PAX4's ability to repress insulin and glucagon ... | Blood Sugar & Diabetes | Strong | |
| rs2295490 | TRIB3 Q84R | TRIB3 pseudokinase missense variant that increases Akt inhibition, impairing ... | Blood Sugar & Diabetes | Strong | |
| rs2466293 | SLC30A8 SLC30A8 Islet Zinc Regulation Variant | 3'UTR variant in the zinc transporter ZnT8 gene that disrupts miRNA binding s... | Blood Sugar & Diabetes | Moderate | |
| rs2854117 | APOC3 APOC3 C-482T | Promoter variant in APOC3 disrupting insulin-responsive regulation of apolipo... | Triglycerides & Fatty Acids | Moderate | |
| rs8192678 | PPARGC1A Gly482Ser | Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha... | Fitness & Body | Strong | |
| rs367643250 | DYRK1B R102C | Rare gain-of-function variant causing autosomal dominant metabolic syndrome (... | Blood Sugar & Diabetes | Strong | |
| rs3758391 | SIRT1 | Promoter-region variant in SIRT1 affecting deacetylase expression; T allele e... | Longevity & Aging | Moderate | |
| rs3787345 | PTPN1 PTPN1 LD Block Co-Variant | Intronic PTPN1 tag SNP within the 100-kb PTP1B insulin-resistance haplotype b... | Blood Sugar & Diabetes | Moderate | |
| rs3787348 | PTPN1 PTPN1 intronic variant | Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ... | Blood Sugar & Diabetes | Moderate | |
| rs4783244 | CDH13 | Intronic CDH13 variant altering T-cadherin expression; T allele carriers have... | Triglycerides & Fatty Acids | Strong | |
| rs4807015 | PTPRS PTPRS T2D risk variant | Intronic PTPRS variant that tags elevated type 2 diabetes risk in both sexes ... | Blood Sugar & Diabetes | Moderate | |
| rs4812829 | HNF4A HNF4A Intronic T2D Risk Variant | Common intronic variant in HNF4A associated with modestly elevated type 2 dia... | Blood Sugar & Diabetes | Strong | |
| rs587777380 | DYRK1B H90P / H90R | Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the D... | Blood Sugar & Diabetes | Strong | |
| rs6020611 | PTPN1 | Intronic PTPN1 tag SNP in the PTP1B regulatory LD block; the minor A allele i... | Blood Sugar & Diabetes | Moderate | |
| rs6067484 | PTPN1 PTPN1 rs6067484 | Intronic PTPN1 tag SNP raising LDL cholesterol risk in lean individuals | Blood Sugar & Diabetes | Moderate | |
| rs653178 | SH2B3 ATXN2/SH2B3 12q24 pleiotropic locus | Pleiotropic 12q24 locus variant in SH2B3 (LNK) modulating JAK-STAT cytokine s... | Blood Sugar & Diabetes | Strong | |
| rs780095 | GCKR GCKR Glucose-Lipid Regulation Variant | Intronic GCKR enhancer variant on the CGG regulatory haplotype; the G allele ... | Blood Sugar & Diabetes | Moderate | |
| rs9402571 | SGK1 | Regulatory variant in SGK1 (serum/glucocorticoid regulated kinase 1) — the mi... | Blood Sugar & Diabetes | Moderate | |
| rs941798 | PTPN1 | Intronic PTPN1 variant tagging a haplotype block associated with reduced insu... | Blood Sugar & Diabetes | Moderate |