Tag
Longevity
51 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10482605 | NR3C1 | NR3C1 promoter variant reducing glucocorticoid receptor transcription; G alle... | Longevity & Aging | Moderate | |
| rs10515522 | NR3C1 | Intronic NR3C1 variant associated with longevity in Polish nonagenarians and ... | Longevity & Aging | Emerging | |
| rs10936599 | TERC Near gene (3q26.2) | Near-TERC regulatory variant where the minor T allele associates with shorter... | Longevity & Aging | Established | |
| rs11212617 | ATM | Intronic variant near the ATM gene affecting metformin's activation of AMPK; ... | Longevity & Aging | Moderate | |
| rs1136410 | PARP1 Val762Ala | Missense variant in the PARP1 catalytic domain that reduces enzymatic activit... | Longevity & Aging | Strong | |
| rs11555236 | SIRT3 | Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre... | Longevity & Aging | Moderate | |
| rs121918393 | APOE Christchurch (R136S) | Ultra-rare APOE3 missense variant that dramatically reduces HSPG binding and ... | Longevity & Aging | Strong | |
| rs12212067 | FOXO3 | Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac... | Longevity & Aging | Strong | |
| rs13181 | ERCC2 Lys751Gln | Missense variant in the XPD helicase that reduces nucleotide excision repair ... | Longevity & Aging | Strong | |
| rs13217795 | FOXO3 | Original 2008 Willcox longevity discovery variant; C allele tags the protecti... | Longevity & Aging | Strong | |
| rs140926439 | FN1 | Rare missense variant in fibronectin 1 that reduces Alzheimer's disease risk ... | Longevity & Aging | Emerging | |
| rs1524107 | IL6 | Intronic IL6 variant tagging a low-producing haplotype — the T allele is prot... | Longevity & Aging | Moderate | |
| rs1801516 | ATM D1853N | Missense variant in the ATM DNA-damage kinase associated with increased radia... | Longevity & Aging | Moderate | |
| rs1805097 | IRS2 Gly1057Asp | Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ... | Longevity & Aging | Moderate | |
| rs1935949 | FOXO3 | Second independent FOXO3 longevity signal tagging a distinct intronic haploty... | Longevity & Aging | Moderate | |
| rs199347 | GPNMB | Intronic GPNMB variant that acts as a brain eQTL; the A allele increases GPNM... | Longevity & Aging | Strong | |
| rs2854747 | IGFBP3 | Intronic variant in IGFBP3 — the gene encoding the main carrier protein for I... | Fat Storage & Energy | Moderate | |
| rs2069837 | IL6 | Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB... | Longevity & Aging | Moderate | |
| rs2153960 | FOXO3 | Intronic FOXO3 tag SNP whose A allele associates with higher circulating IGF-... | Longevity & Aging | Moderate | |
| rs3184504 | SH2B3 R262W | Pleiotropic missense variant reducing SH2B3 inhibitory function, increasing b... | Coronary Artery Disease & Atherosclerosis | Strong | |
| rs2229765 | IGF1R c.3179G>A (E1013E) | Synonymous IGF1R variant associated with lower circulating IGF-1 levels and e... | Longevity & Aging | Moderate | |
| rs2274700 | CFH A473A | Synonymous CFH variant in complete LD with rs1410996 that tags the complement... | Longevity & Aging | Strong | |
| rs708272 | CETP TaqIB | Influences HDL cholesterol levels and particle size through effects on choles... | Atherogenic Lipoproteins | Strong | |
| rs2295080 | MTOR | Promoter variant that reduces mTOR expression; the G allele lowers mTOR trans... | Longevity & Aging | Moderate | |
| rs2402970 | NRF1 | Intronic NRF1 variant associated with baseline differences in ventilatory thr... | Longevity & Aging | Moderate | |
| rs2536 | MTOR | 3'UTR variant that alters miR-150 binding affinity; the C allele increases mi... | Longevity & Aging | Moderate | |
| rs2542052 | APOC3 | Promoter variant that reduces APOC3 expression, associated with lower triglyc... | Longevity & Aging | Strong | |
| rs4977574 | CDKN2B-AS1 9p21.3 | 9p21.3 CAD risk signal in ANRIL; G allele elevates coronary artery disease ri... | Coronary Artery Disease & Atherosclerosis | Established | |
| rs2672598 | HTRA1 | Promoter variant at -487 in HTRA1 that elevates HTRA1 serine protease express... | Longevity & Aging | Strong | |
| rs2736100 | TERT | Common intron 2 variant in the telomerase gene that influences telomere lengt... | Longevity & Aging | Strong | |
| rs2764264 | FOXO3 | Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit... | Longevity & Aging | Strong | |
| rs2779249 | NOS2 Promoter -1026C/A | Functional promoter variant that increases iNOS transcriptional activity up t... | Longevity & Aging | Moderate | |
| rs7986407 | FOXO1 | Intronic variant in FOXO1, a pro-apoptotic transcription factor whose suppres... | Endometriosis & Uterine Health | Strong | |
| rs2802292 | FOXO3 | Longevity-associated intronic enhancer variant | Longevity & Aging | Established | |
| rs2811712 | CDKN2BAS | Regulatory variant in the ANRIL long non-coding RNA at the 9p21.3 locus that ... | Longevity & Aging | Moderate | |
| rs8192678 | PPARGC1A Gly482Ser | Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha... | Fitness & Body | Strong | |
| rs2963154 | NR3C1 | Intronic NR3C1 variant with TT genotype enriched in Polish centenarians; C al... | Longevity & Aging | Emerging | |
| rs350845 | SIRT6 | Intronic eQTL in SIRT6 where the rare A allele upregulates SIRT6 expression a... | Longevity & Aging | Moderate | |
| rs3758391 | SIRT1 | Promoter-region variant in SIRT1 affecting deacetylase expression; T allele e... | Longevity & Aging | Moderate | |
| rs4946935 | FOXO3 | Functionally validated FOXO3 intronic variant that creates an SRF binding sit... | Longevity & Aging | Strong | |
| rs4975605 | TERT | Intronic TERT variant influencing telomere maintenance, associated with testi... | Longevity & Aging | Moderate | |
| rs551397 | CFH | Intronic CFH variant that tags the AMD-risk haplotype; the C allele tracks co... | Longevity & Aging | Moderate | |
| rs5882 | CETP I405V | Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi... | Longevity & Aging | Moderate | |
| rs6198 | NR3C1 9β | 3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,... | Longevity & Aging | Strong | |
| rs6721961 | NFE2L2 | Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th... | Longevity & Aging | Moderate | |
| rs6949152 | NRF1 | Intronic variant in the master mitochondrial biogenesis transcription factor ... | Longevity & Aging | Moderate | |
| rs7137828 | ATXN2 | Intronic ATXN2 variant associated with primary open-angle glaucoma risk; T al... | Longevity & Aging | Strong | |
| rs7675998 | NAF1 | Regulatory variant near the NAF1 telomerase assembly gene associated with sho... | Longevity & Aging | Strong | |
| rs7895833 | SIRT1 A>G | Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ... | Longevity & Aging | Moderate | |
| rs9420907 | OBFC1 | Intronic variant in the CST complex component STN1/OBFC1 that influences telo... | Longevity & Aging | Strong | |
| rs9470080 | FKBP5 | Intronic FKBP5 variant in the stress-aging haplotype block — T allele carrier... | Longevity & Aging | Strong |