Tag

Mental Health

44 genetic variants with this tag.

RSID	Gene	Description	Category
rs1006737	CACNA1C	L-type calcium channel gene variant affecting mood regulation, emotional proc...	Mood & Behavior	Mental Health	Strong
rs10514299	TMEM161B-MEF2C TMEM161B-MEF2C intergenic variant	Intronic variant near the MEF2C transcription factor locus associated with in...	Mood & Behavior	Mental Health	Strong
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Mood & Behavior	Mental Health	Established
rs10947690	MDGA1 Leu61Pro	Missense variant in the inhibitory synapse regulator MDGA1 that impairs neuro...	Hormones & Sleep	Mental Health	Strong
rs1058164	CYP2D6	Synonymous CYP2D6 variant that promotes exon 3 skipping, reducing functional ...	Pharmacogenomics	Mental Health	Moderate
rs12624433	SLC12A5 KCC2 Chloride Transport	Intronic variant in SLC12A5 reducing KCC2 potassium-chloride cotransporter fu...	Mood & Behavior	Mental Health	Moderate
rs1064395	NCAN	3' UTR variant in the neurocan gene associated with bipolar disorder and schi...	Neurology & Cognition	Mental Health	Strong
rs1387923	NTRK2 NTRK2/TrkB 3'UTR variant	3' UTR variant in the TrkB receptor gene affecting NTRK2 expression; associat...	Mood & Behavior	Mental Health	Moderate
rs1545843	SLC6A15 SLC6A15 depression risk variant	Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show...	Mood & Behavior	Mental Health	Strong
rs12696304	TERC	Regulatory variant near the telomerase RNA gene associated with shorter telom...	Longevity & Aging	Mental Health	Established
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Mood & Behavior	Mental Health	Established
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Mood & Behavior	Mental Health	Moderate
rs16847897	TERC	Regulatory variant at the TERC locus associated with shorter telomeres and ac...	Longevity & Aging	Mental Health	Strong
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Mood & Behavior	Mental Health	Strong
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	Mental Health	Moderate
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Mood & Behavior	Mental Health	Moderate
rs184039278	CRY1 CRY1Δ11	Splice-site variant in the circadian clock gene CRY1 that causes exon 11 skip...	Hormones & Sleep	Mental Health	Strong
rs279858	GABRA2 K132K	GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ...	Mood & Behavior	Mental Health	Strong
rs324420	FAAH Pro129Thr	Affects anandamide levels through altered FAAH enzyme stability, influencing ...	Mood & Behavior	Mental Health	Strong
rs35936514	LHPP LHPP depression risk variant	Intronic/3'UTR variant in LHPP, a histidine phosphatase essential for stress ...	Mood & Behavior	Mental Health	Strong
rs41423247	NR3C1 BclI	Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s...	Mood & Behavior	Mental Health	Strong
rs1718119	P2RX7 Ala348Thr	Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f...	Neurology & Cognition	Mental Health	Moderate
rs4395923	CYP7B1 CYP7B1 Neurosteroid Hydroxylase	Intronic variant in the brain neurosteroid hydroxylase gene affecting DHEA an...	Mood & Behavior	Mental Health	Emerging
rs4570625	TPH2 G-703T	Promoter variant affecting brain serotonin synthesis enzyme; influences emoti...	Mood & Behavior	Mental Health	Moderate
rs2736100	TERT	Common intron 2 variant in the telomerase gene that influences telomere lengt...	Longevity & Aging	Mental Health	Strong
rs578776	CHRNA3 3' UTR	CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10...	Mood & Behavior	Mental Health	Strong
rs588765	CHRNA5 5' UTR / Locus 3	Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres...	Mood & Behavior	Mental Health	Strong
rs6295	HTR1A C-1019G	Functional promoter variant in the serotonin 1A receptor gene that increases ...	Mood & Behavior	Mental Health	Strong
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Mood & Behavior	Mental Health	Moderate
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Mood & Behavior	Mental Health	Strong
rs2229431	INSR	Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee...	Blood Sugar & Diabetes	Mental Health	Emerging
rs73034295	IGSF9B IGSF9B Inhibitory Synapse Adhesion	Intronic variant in the gene encoding the inhibitory synaptic adhesion protei...	Mood & Behavior	Mental Health	Emerging
rs208294	P2RX7 His155Tyr	Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas...	Neurology & Cognition	Mental Health	Moderate
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Mood & Behavior	Mental Health	Strong
rs2230912	P2RX7 Gln460Arg	Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ...	Neurology & Cognition	Mental Health	Moderate
rs956572	BCL2	Intronic variant in the anti-apoptotic gene BCL2 that affects BCL2 expression...	Mood & Behavior	Mental Health	Moderate
rs6198	NR3C1 9β	3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,...	Longevity & Aging	Mental Health	Strong
rs4307059	CDH9/CDH10	Intergenic variant at 5p14.1 between neuronal cell-adhesion genes CDH9 and CD...	Hormones & Sleep	Mental Health	Strong
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Mental Health	Moderate
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Longevity & Aging	Mental Health	Strong
rs55694368	PER2 PER2 regulatory variant	Upstream regulatory signal near the core circadian clock gene PER2 that shift...	Hormones & Sleep	Mental Health	Strong
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Mental Health	Established
rs72547511	CYP1A2 CYP1A2*15 (Pro42Arg)	Rare CYP1A2 missense variant at the critical Pro42 position; nearly abolishes...	Pharmacogenomics	Mental Health	Moderate
rs72549354	CYP2D6 *20	Frameshift insertion creating a null CYP2D6 allele; carriers cannot metaboliz...	Pharmacogenomics	Mental Health	Established