Tag
Mental Health
27 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1006737 | CACNA1C | L-type calcium channel gene variant affecting mood regulation, emotional proc... | Mood & Behavior | Strong | |
| rs10514299 | TMEM161B-MEF2C TMEM161B-MEF2C intergenic variant | Intronic variant near the MEF2C transcription factor locus associated with in... | Mood & Behavior | Strong | |
| rs1051730 | CHRNA3 Tyr215Tyr | CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass... | Mood & Behavior | Established | |
| rs1064395 | NCAN | 3' UTR variant in the neurocan gene associated with bipolar disorder and schi... | Neurology & Cognition | Strong | |
| rs1545843 | SLC6A15 SLC6A15 depression risk variant | Variant reducing SLC6A15 expression in hippocampus; AA carriers show increase... | Mood & Behavior | Strong | |
| rs16969968 | CHRNA5 Asp398Asn | Nicotinic receptor variant strongly associated with heavy smoking, nicotine d... | Mood & Behavior | Established | |
| rs184039278 | CRY1 CRY1Δ11 | Splice-site variant in the circadian clock gene CRY1 that causes exon 11 skip... | Hormones & Sleep | Strong | |
| rs2036527 | CHRNA5/CHRNA3 | Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr... | Mood & Behavior | Strong | |
| rs2522833 | PCLO Ser4814Ala | Missense variant in the C2A calcium-binding domain of presynaptic scaffolding... | Mood & Behavior | Moderate | |
| rs25531 | SLC6A4 A>G | Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and... | Mood & Behavior | Moderate | |
| rs279858 | GABRA2 K132K | GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ... | Mood & Behavior | Strong | |
| rs324420 | FAAH Pro129Thr | Affects anandamide levels through altered FAAH enzyme stability, influencing ... | Mood & Behavior | Strong | |
| rs4570625 | TPH2 G-703T | Promoter variant affecting brain serotonin synthesis enzyme; influences emoti... | Mood & Behavior | Moderate | |
| rs2229431 | INSR | Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee... | Blood Sugar & Diabetes | Emerging | |
| rs2736100 | TERT | Common intron 2 variant in the telomerase gene that influences telomere lengt... | Longevity & Aging | Strong | |
| rs588765 | CHRNA5 5' UTR / Locus 3 | Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres... | Mood & Behavior | Strong | |
| rs6311 | HTR2A -1438G>A | Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ... | Mood & Behavior | Moderate | |
| rs6323 | MAOA R297R | X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans... | Mood & Behavior | Strong | |
| rs1718119 | P2RX7 Ala348Thr | Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f... | Neurology & Cognition | Moderate | |
| rs8034191 | AGPHD1/CHRNA3 15q25.1 intergenic | Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re... | Mood & Behavior | Strong | |
| rs956572 | BCL2 | Intronic variant in the anti-apoptotic gene BCL2 that affects BCL2 expression... | Mood & Behavior | Moderate | |
| rs55694368 | PER2 PER2 regulatory variant | Upstream regulatory signal near the core circadian clock gene PER2 that shift... | Hormones & Sleep | Strong | |
| rs208294 | P2RX7 His155Tyr | Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas... | Neurology & Cognition | Moderate | |
| rs2230912 | P2RX7 Gln460Arg | Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ... | Neurology & Cognition | Moderate | |
| rs6198 | NR3C1 9β | 3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,... | Longevity & Aging | Strong | |
| rs4680 | COMT Val158Met | Dopamine/catecholamine breakdown — affects stress response and methyl donor t... | Methylation & Detox | Established | |
| rs7895833 | SIRT1 A>G | Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ... | Longevity & Aging | Moderate |