Tag

Methylation

20 genetic variants with this tag.

RSID	Gene	Description	Category
rs1801133	MTHFR C677T	Key enzyme for converting folate to its active methylfolate form	Methylation & Detox	Methylation Folate B Vitamins	Established
rs1801131	MTHFR A1298C	Second MTHFR variant affecting enzyme activity in the regulatory domain	Methylation & Detox	Methylation Folate B Vitamins	Moderate
rs1051266	SLC19A1 G80A (His27Arg)	Folate transporter — how well folate gets into your cells	Methylation & Detox	Methylation Folate B Vitamins	Moderate
rs2236225	MTHFD1 G1958A	Folate processing enzyme — reduced stability increases choline need	Methylation & Detox	Methylation Folate B Vitamins	Strong
rs1801394	MTRR A66G	B12 recycling enzyme — regenerates active B12 for the methylation cycle	Methylation & Detox	Methylation B Vitamins Homocysteine	Moderate
rs1805087	MTR A2756G	Methionine synthase — uses B12 to convert homocysteine to methionine	Methylation & Detox	Methylation B Vitamins Homocysteine	Moderate
rs1544410	VDR BsmI	Vitamin D receptor — affects how well vitamin D activates cellular processes	Methylation & Detox	B Vitamins Methylation Diet	Moderate
rs10741657	CYP2R1 promoter variant	Vitamin D activation — converts D3 to 25(OH)D in the liver	Methylation & Detox	B Vitamins Methylation Diet	Strong
rs7946	PEMT Val175Met	Phosphatidylcholine production — affects dietary choline requirements	Methylation & Detox	Methylation Folate B Vitamins	Strong
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Methylation Neurotransmitters Detoxification	Established
rs234706	CBS C699T	Common synonymous variant in the CBS gene associated with reduced cardiovascu...	Methylation & Detox	Methylation Cardiovascular Folate	Moderate
rs1801181	CBS A360A	A synonymous variant in CBS affecting homocysteine metabolism and associated ...	Methylation & Detox	Methylation Homocysteine B Vitamins	Moderate
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Sleep Melatonin Circadian	Moderate
rs567754	BHMT BHMT-02	Intronic variant in betaine-homocysteine methyltransferase gene associated wi...	Methylation & Detox	Methylation Homocysteine B Vitamins	Moderate
rs1979277	SHMT1 C1420T	Alters one-carbon metabolism and folate distribution; influences cancer risk,...	Methylation & Detox	Methylation Folate B Vitamins	Moderate
rs819147	AHCY	Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...	Methylation & Detox	Methylation Homocysteine Cardiovascular	Moderate
rs1801198	TCN2 Pro259Arg (C776G)	Transcobalamin II variant affecting cellular delivery of vitamin B12 via holo...	Nutrition & Metabolism	Vitamin B12 B Vitamins Methylation	Strong
rs1050891	HNMT 3'UTR variant	Histamine breakdown in blood and tissues - uses methyl groups from SAM	Methylation & Detox	Histamine Methylation Detoxification	Moderate
rs11558538	HNMT Thr105Ile	HNMT structural variant - reduces enzyme stability and histamine clearance in...	Methylation & Detox	Histamine Methylation Detoxification	Strong
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Detoxification Antioxidants Oxidative Stress	Strong