|
rs1801133
|
MTHFR
C677T
|
Key enzyme for converting folate to its active methylfolate form
|
Methylation & Detox
|
|
Established
|
|
rs1801131
|
MTHFR
A1298C
|
Second MTHFR variant affecting enzyme activity in the regulatory domain
|
Methylation & Detox
|
|
Moderate
|
|
rs1051266
|
SLC19A1
G80A (His27Arg)
|
Folate transporter — how well folate gets into your cells
|
Methylation & Detox
|
|
Moderate
|
|
rs2236225
|
MTHFD1
G1958A
|
Folate processing enzyme — reduced stability increases choline need
|
Methylation & Detox
|
|
Strong
|
|
rs1801394
|
MTRR
A66G
|
B12 recycling enzyme — regenerates active B12 for the methylation cycle
|
Methylation & Detox
|
|
Moderate
|
|
rs1805087
|
MTR
A2756G
|
Methionine synthase — uses B12 to convert homocysteine to methionine
|
Methylation & Detox
|
|
Moderate
|
|
rs1544410
|
VDR
BsmI
|
Vitamin D receptor — affects how well vitamin D activates cellular processes
|
Methylation & Detox
|
|
Moderate
|
|
rs10741657
|
CYP2R1
promoter variant
|
Vitamin D activation — converts D3 to 25(OH)D in the liver
|
Methylation & Detox
|
|
Strong
|
|
rs7946
|
PEMT
Val175Met
|
Phosphatidylcholine production — affects dietary choline requirements
|
Methylation & Detox
|
|
Strong
|
|
rs4680
|
COMT
Val158Met
|
Dopamine/catecholamine breakdown — affects stress response and methyl donor t...
|
Methylation & Detox
|
|
Established
|
|
rs234706
|
CBS
C699T
|
Common synonymous variant in the CBS gene associated with reduced cardiovascu...
|
Methylation & Detox
|
|
Moderate
|
|
rs1801181
|
CBS
A360A
|
A synonymous variant in CBS affecting homocysteine metabolism and associated ...
|
Methylation & Detox
|
|
Moderate
|
|
rs4446909
|
ASMT
Promoter A>G
|
Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...
|
Hormones & Sleep
|
|
Moderate
|
|
rs567754
|
BHMT
BHMT-02
|
Intronic variant in betaine-homocysteine methyltransferase gene associated wi...
|
Methylation & Detox
|
|
Moderate
|
|
rs1979277
|
SHMT1
C1420T
|
Alters one-carbon metabolism and folate distribution; influences cancer risk,...
|
Methylation & Detox
|
|
Moderate
|
|
rs819147
|
AHCY
|
Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...
|
Methylation & Detox
|
|
Moderate
|
|
rs1801198
|
TCN2
Pro259Arg (C776G)
|
Transcobalamin II variant affecting cellular delivery of vitamin B12 via holo...
|
Nutrition & Metabolism
|
|
Strong
|
|
rs1050891
|
HNMT
3'UTR variant
|
Histamine breakdown in blood and tissues - uses methyl groups from SAM
|
Methylation & Detox
|
|
Moderate
|
|
rs11558538
|
HNMT
Thr105Ile
|
HNMT structural variant - reduces enzyme stability and histamine clearance in...
|
Methylation & Detox
|
|
Strong
|
|
rs1001179
|
CAT
-262C>T
|
Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...
|
Methylation & Detox
|
|
Strong
|
|
rs602662
|
FUT2
Gly258Ser
|
Missense variant in the FUT2 fucosyltransferase enzyme that alters haptocorri...
|
Nutrition & Metabolism
|
|
Strong
|
|
rs4654748
|
NBPF3
|
Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...
|
Nutrition & Metabolism
|
|
Strong
|
|
rs1256335
|
ALPL
|
Intronic variant near ALPL associated with increased alkaline phosphatase act...
|
Nutrition & Metabolism
|
|
Strong
|
|
rs61735836
|
FTCD
|
Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...
|
Nutrition & Metabolism
|
|
Strong
|
|
rs234709
|
CBS
|
Intronic CBS variant that tags the CBS locus in GWAS studies; associated with...
|
Nutrition & Metabolism
|
|
Moderate
|
|
rs78060698
|
FUT6
|
Intronic regulatory variant in FUT6 that alters HNF4α binding and fucosyltran...
|
Nutrition & Metabolism
|
|
Moderate
|
|
rs12272669
|
UNKNOWN
|
Intergenic variant on chromosome 11q13.4 associated with circulating vitamin ...
|
Nutrition & Metabolism
|
|
Emerging
|