Tag

Fat Metabolism

67 genetic variants with this tag.

RSID	Gene	Description	Category
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Nutrition & Metabolism	Diabetes Fat Metabolism Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Nutrition & Metabolism	Diabetes Insulin Fat Metabolism	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Nutrition & Metabolism	Diabetes Insulin Diet	Established
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Nutrition & Metabolism	Cholesterol Cardiovascular Alzheimer's	Established
rs7412	APOE E2 determinant	APOE E2 variant - generally protective for cardiovascular health	Nutrition & Metabolism	Cholesterol Cardiovascular Fat Metabolism	Established
rs174547	FADS1	Omega-3 fatty acid conversion efficiency - affects ability to make EPA/DHA fr...	Nutrition & Metabolism	Omega-3 Fat Metabolism Diet	Strong
rs3135506	APOA5 S19W	Triglyceride metabolism - affects fasting triglyceride levels and cardiovascu...	Nutrition & Metabolism	Triglycerides Cardiovascular Fat Metabolism	Strong
rs4253778	PPARA intron 7 G/C	Regulates fatty acid oxidation and muscle fiber composition, influencing endu...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs1799883	FABP2 Ala54Thr	Intestinal fat absorption - affects how efficiently you absorb dietary fat	Nutrition & Metabolism	Fat Metabolism Diet Insulin	Moderate
rs11555236	SIRT3	Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs2542052	APOC3	Promoter variant that reduces APOC3 expression, associated with lower triglyc...	Longevity & Aging	Longevity Triglycerides Cardiovascular	Strong
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Heart & Inflammation	Triglycerides Cardiovascular Cholesterol	Strong
rs8192678	PPARGC1A Gly482Ser	Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha...	Longevity & Aging	Fitness Endurance Diabetes	Strong
rs1800588	LIPC -514C>T	Promoter variant that reduces hepatic lipase activity, raising HDL-C levels b...	Heart & Inflammation	Cholesterol Fat Metabolism Cardiovascular	Strong
rs7664413	VEGFC	Intronic variant in the primary lymphangiogenesis growth factor gene associat...	Immune & Gut	Lymphatic Lipedema Fat Metabolism	Emerging
rs662799	APOA5 -1131T>C	Promoter variant that reduces APOA5 expression, impairing lipoprotein lipase ...	Heart & Inflammation	Triglycerides Fat Metabolism Cardiovascular	Strong
rs12086634	HSD11B1 Intron 3 variant	Modulates local cortisol activation from cortisone in liver and adipose tissu...	Hormones & Sleep	Cortisol HPA Axis Metabolic Syndrome	Moderate
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Heart & Inflammation	Cardiovascular Diabetes Insulin	Moderate
rs2241766	ADIPOQ T45G	Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability...	Heart & Inflammation	Fat Metabolism Obesity Insulin	Moderate
rs6905288	VEGFA	Adipose tissue vascularization variant near VEGFA influencing fat distributio...	Heart & Inflammation	Fat Metabolism Cardiovascular Insulin	Moderate
rs243865	MMP2 C-1306T	Promoter polymorphism that disrupts an Sp1-binding site and reduces MMP-2 enz...	Fitness & Body	Connective Tissue Extracellular Matrix Inflammation	Moderate
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Nutrition & Metabolism	Fat Metabolism Triglycerides Diet	Established
rs2016520	PPARD +294T>C	Regulatory variant that increases PPARD transcription, enhancing fat oxidatio...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs1053049	PPARD 3'UTR variant	3'UTR variant in PPARD that acts as the third tag in the elite athlete haplot...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs2267668	PPARD Intron variant (5' region)	Intronic PPARD variant that impairs aerobic fitness gains and body compositio...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs1800592	UCP1 A-3826G	Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs1800849	UCP3 -55C>T	Promoter variant in skeletal muscle uncoupling protein 3 that increases UCP3 ...	Nutrition & Metabolism	Fat Metabolism Diabetes Insulin	Moderate
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Strong
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Nutrition & Metabolism	Leptin Satiety Obesity	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Nutrition & Metabolism	Obesity Appetite Diet	Moderate
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Nutrition & Metabolism	Obesity Fat Metabolism Diet	Moderate
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Nutrition & Metabolism	Obesity Appetite Metabolic Syndrome	Moderate
rs10423928	GIPR	Intronic GIPR variant that reduces functional GIP receptor expression via alt...	Nutrition & Metabolism	Diabetes Insulin Diet	Strong
rs10195252	GRB14/COBLL1	Intergenic variant between GRB14 and COBLL1 that acts as an eQTL for GRB14 in...	Nutrition & Metabolism	Fat Metabolism Insulin Lipedema	Strong
rs9491696	RSPO3	Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin Resistance	Strong
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Strong
rs2651899	PRDM16	Intronic variant in the master regulator of brown/beige fat differentiation, ...	Nutrition & Metabolism	Fat Metabolism Thermogenesis Cardiovascular	Moderate
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Nutrition & Metabolism	Obesity Appetite Fat Metabolism	Strong
rs11172113	LRP1	Intronic enhancer variant in LRP1 that regulates receptor expression in brain...	Nutrition & Metabolism	Leptin Cardiovascular Brain Health	Moderate
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Nutrition & Metabolism	Obesity Appetite Diabetes	Moderate
rs6947337	INHBA	Activin A signaling variant near INHBA linking adipocyte dysfunction to share...	Nutrition & Metabolism	Obesity Fat Metabolism Inflammation	Moderate
rs29941	KCTD15	GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...	Nutrition & Metabolism	Obesity Fat Metabolism Adipogenesis	Moderate
rs10838738	MTCH2	Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance...	Nutrition & Metabolism	Obesity Mitochondria Energy Metabolism	Moderate
rs987237	TFAP2B	Adipocyte transcription factor variant influencing central fat distribution a...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Moderate
rs1776897	HMGA1	Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2241423	MAP2K5	MAPK signaling variant in MAP2K5 associated with BMI through altered adipogen...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs11057830	SCARB1	Intronic variant in SCARB1 that affects SR-BI receptor function and the intes...	Nutrition & Metabolism	Vitamin E Vitamins Fat Metabolism	Moderate
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Nutrition & Metabolism	HDL Cholesterol Fat Metabolism Cholesterol	Strong
rs174537	FADS1	Regulatory variant in the FADS1 locus that controls delta-5 desaturase expres...	Nutrition & Metabolism	Omega-3 Fat Metabolism Cardiovascular	Strong
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Nutrition & Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Nutrition & Metabolism	Obesity Metabolic Fat Metabolism	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Nutrition & Metabolism	Obesity Leptin Insulin Resistance	Strong
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Nutrition & Metabolism	Obesity Satiety Appetite	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Nutrition & Metabolism	Obesity Appetite Neurotransmitters	Strong
rs72613567	HSD17B13 Splice Variant (;A)	Protective adenine insertion disrupting the HSD17B13 splice donor site, produ...	Nutrition & Metabolism	Liver Health Fat Metabolism Alcohol	Established
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Nutrition & Metabolism	Liver Health Fat Metabolism Cholesterol	Established
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Nutrition & Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs2954021	TRIB1	Near-gene variant influencing hepatic lipid metabolism; G allele raises trigl...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Established
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Nutrition & Metabolism	Liver Health Fat Metabolism Triglycerides	Strong
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Nutrition & Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Nutrition & Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs6834314	HSD17B13	Intergenic tag SNP in near-perfect linkage disequilibrium with the HSD17B13 s...	Nutrition & Metabolism	Liver Health Fat Metabolism Liver Disease	Moderate