Tag

Aging

54 genetic variants with this tag.

RSID	Gene	Description	Category
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Longevity Aging Cardiovascular	Established
rs2736100	TERT	Common intron 2 variant in the telomerase gene that influences telomere lengt...	Longevity & Aging	Mental Health Telomere Biology Aging	Strong
rs1799750	MMP1 1G/2G	Promoter polymorphism affecting MMP1 expression and collagen degradation rate...	Skin & Eyes	Skin, Hair & Pigmentation Cardiovascular Diet	Strong
rs2180439	WNT10A	Lead SNP at the 20p11 locus, the strongest autosomal genetic risk factor for ...	Skin & Eyes	Skin, Hair & Pigmentation Aging Hormones	Strong
rs2295080	MTOR	Promoter variant that reduces mTOR expression; the G allele lowers mTOR trans...	Longevity & Aging	Longevity Aging Autophagy	Moderate
rs1061170	CFH Y402H	Strongly increases risk of age-related macular degeneration through impaired ...	Skin & Eyes	Eye Health Inflammation Cardiovascular	Established
rs6721961	NFE2L2	Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th...	Longevity & Aging	Oxidative Stress Antioxidants Detoxification	Moderate
rs1042522	TP53 Pro72Arg	p53 codon 72 polymorphism producing two functionally distinct proteins — Arg7...	Longevity & Aging	Longevity Aging Cancer Risk	Strong
rs10490924	ARMS2 A69S	Second strongest genetic risk factor for age-related macular degeneration, af...	Skin & Eyes	Eye Health Aging Antioxidants	Established
rs2229765	IGF1R c.3179G>A (E1013E)	Synonymous IGF1R variant associated with lower circulating IGF-1 levels and e...	Longevity & Aging	Longevity Insulin Growth Factors	Moderate
rs2230199	C3 R102G	Missense variant in complement C3 increasing risk of age-related macular dege...	Skin & Eyes	Eye Health Inflammation Aging	Established
rs350845	SIRT6	Intronic eQTL in SIRT6 where the rare A allele upregulates SIRT6 expression a...	Longevity & Aging	Longevity Aging Telomere Biology	Moderate
rs4236601	CAV1	Intergenic variant near caveolin genes affecting primary open-angle glaucoma ...	Skin & Eyes	Eye Health Cardiovascular Aging	Strong
rs11555236	SIRT3	Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs2542052	APOC3	Promoter variant that reduces APOC3 expression, associated with lower triglyc...	Longevity & Aging	Longevity Triglycerides Cardiovascular	Strong
rs659366	UCP2	Promoter variant at position -866 of UCP2 that controls mitochondrial uncoupl...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs5882	CETP I405V	Missense variant that reduces CETP enzyme activity, raising HDL-C and enlargi...	Longevity & Aging	Longevity Aging Cholesterol	Moderate
rs13181	ERCC2 Lys751Gln	Missense variant in the XPD helicase that reduces nucleotide excision repair ...	Longevity & Aging	DNA Repair Longevity Aging	Strong
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Brain & Mental Health	Alzheimer's Neurological Risk Neuroinflammation	Established
rs1333049	CDKN2B-AS1 9p21 locus	Strongest GWAS signal for coronary artery disease; risk C allele accelerates ...	Longevity & Aging	Cardiovascular Diet Lifestyle	Established
rs1935949	FOXO3	Second independent FOXO3 longevity signal tagging a distinct intronic haploty...	Longevity & Aging	Longevity Aging Oxidative Stress	Moderate
rs3736228	LRP5 A1330V	Wnt signaling co-receptor variant affecting bone mineral density and fracture...	Fitness & Body	Bone & Joint Osteoporosis Cardiovascular	Strong
rs17649553	MAPT H1/H2 Haplotype Tag	Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting ris...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Longevity Aging Cardiovascular	Strong
rs143383	GDF5 C/T	Regulatory variant in GDF5 affecting cartilage development and osteoarthritis...	Fitness & Body	Bone & Joint Cartilage Inflammation	Established
rs6198	NR3C1 9β	3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,...	Longevity & Aging	Longevity Aging HPA Axis	Strong
rs2069837	IL6	Intronic IL6 enhancer variant that regulates the anti-inflammatory gene GPNMB...	Longevity & Aging	Longevity Aging Inflammation	Moderate
rs3025058	MMP3 5A/6A	Promoter polymorphism affecting MMP3 enzyme expression levels, influencing ca...	Fitness & Body	Bone & Joint Inflammation Cardiovascular	Strong
rs3803304	AKT1	Intronic AKT1 variant near a conserved exon-intron boundary; the G allele is ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs16847897	TERC	Regulatory variant at the TERC locus associated with shorter telomeres and ac...	Longevity & Aging	Telomere Biology Aging Longevity	Strong
rs11212617	ATM	Intronic variant near the ATM gene affecting metformin's activation of AMPK; ...	Longevity & Aging	Longevity Aging DNA Repair	Moderate
rs6949152	NRF1	Intronic variant in the master mitochondrial biogenesis transcription factor ...	Longevity & Aging	Mitochondria Longevity Aging	Moderate
rs4946935	FOXO3	Functionally validated FOXO3 intronic variant that creates an SRF binding sit...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs12206094	FOXO3	Functional FOXO3 intronic variant with allele-specific CTCF binding and IGF-1...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs2963154	NR3C1	Intronic NR3C1 variant with TT genotype enriched in Polish centenarians; C al...	Longevity & Aging	Longevity Aging HPA Axis	Emerging
rs10515522	NR3C1	Intronic NR3C1 variant associated with longevity in Polish nonagenarians and ...	Longevity & Aging	Longevity Aging Stress Response	Emerging
rs2402970	NRF1	Intronic NRF1 variant associated with baseline differences in ventilatory thr...	Longevity & Aging	Mitochondria Longevity Aging	Moderate
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs2253310	FOXO3	Intronic FOXO3 longevity variant; C allele (minor in East Asians) associated ...	Longevity & Aging	Longevity Aging Oxidative Stress	Moderate
rs12212067	FOXO3	Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac...	Longevity & Aging	Longevity Aging Inflammation	Strong
rs10482605	NR3C1	NR3C1 promoter variant reducing glucocorticoid receptor transcription; G alle...	Longevity & Aging	Longevity Aging HPA Axis	Moderate
rs9470080	FKBP5	Intronic FKBP5 variant in the stress-aging haplotype block — T allele carrier...	Longevity & Aging	Longevity Aging HPA Axis	Strong
rs10936599	TERC Near gene (3q26.2)	Near-TERC regulatory variant where the minor T allele associates with shorter...	Longevity & Aging	Telomere Biology Aging Longevity	Established
rs1800547	MAPT H1/H2 Haplotype Splice Regulator	Intronic MAPT variant that regulates tau exon 3 splicing via hnRNP F/Q bindin...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs9420907	OBFC1	Intronic variant in the CST complex component STN1/OBFC1 that influences telo...	Longevity & Aging	Telomere Biology Aging Longevity	Strong
rs242557	MAPT H1c Sub-haplotype Tag	Intronic MAPT variant tagging the H1c sub-haplotype within the H1 clade, inde...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs7675998	NAF1	Regulatory variant near the NAF1 telomerase assembly gene associated with sho...	Longevity & Aging	Telomere Biology Longevity Cardiovascular	Strong
rs1524107	IL6	Intronic IL6 variant tagging a low-producing haplotype — the T allele is prot...	Longevity & Aging	Inflammation Longevity Aging	Moderate
rs2536	MTOR	3'UTR variant that alters miR-150 binding affinity; the C allele increases mi...	Longevity & Aging	Longevity Aging Autophagy	Moderate
rs1937	TFAM S12T	Missense variant in the TFAM mitochondrial targeting sequence — the C allele ...	Longevity & Aging	Mitochondria Longevity Aging	Moderate
rs2918418	NR3C1	Intronic NR3C1 variant with CC genotype enriched in Polish centenarians; GG g...	Longevity & Aging	Longevity Aging HPA Axis	Emerging
rs2471738	MAPT H1c Sub-haplotype Tag (rs2471738)	Intronic MAPT variant whose T allele co-defines the H1c sub-haplotype, indepe...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong
rs17651213	MAPT Exon 3 Splice Regulator	Intronic MAPT variant that directly regulates tau exon 3 splicing via differe...	Brain & Mental Health	Neurological Risk Parkinson's Dementia	Strong