Tag
Neurotransmitters
52 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1003194 | CALCA/CALCB | Intergenic regulatory variant ~26 kb downstream of CALCB (calcitonin gene-rel... | Neurology & Cognition | Strong | |
| rs10150332 | NRXN3 | Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna... | Appetite & Obesity | Strong | |
| rs10038916 | GRIA1 | Intronic variant in the AMPA glutamate receptor gene GRIA1 associated with re... | Neurology & Cognition | Strong | |
| rs104893665 | SPR Arg150Gly | Pathogenic missense variant in sepiapterin reductase that abolishes BH4 biosy... | Vitamins & Nutrient Absorption | Established | |
| rs1049353 | CNR1 3'UTR (G1359A) | Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp... | Mood & Behavior | Moderate | |
| rs1051730 | CHRNA3 Tyr215Tyr | CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass... | Mood & Behavior | Established | |
| rs121917746 | SPR Q119X | Nonsense variant in sepiapterin reductase that abolishes BH4 biosynthesis, ca... | Vitamins & Nutrient Absorption | Established | |
| rs10786831 | SORCS3 SORCS3 Depression Variant | Intronic variant in the neurotrophin sorting receptor SORCS3, the top GWAS hi... | Mood & Behavior | Strong | |
| rs11599236 | SORCS3 SORCS3 Neurotrophin Sorting | Intronic variant in the BDNF-receptor trafficking gene SORCS3, associated wit... | Mood & Behavior | Strong | |
| rs1545843 | SLC6A15 SLC6A15 depression risk variant | Variant reducing SLC6A15 expression in hippocampus; AA carriers show increase... | Mood & Behavior | Strong | |
| rs10839553 | CCKBR | Intronic variant near the cholecystokinin B receptor gene associated with res... | Neurology & Cognition | Strong | |
| rs1611115 | DBH -1021C>T | Strongest known genetic determinant of dopamine beta-hydroxylase activity, co... | Mood & Behavior | Strong | |
| rs10895816 | GRIA4 | Intronic variant in the AMPA glutamate receptor gene GRIA4 associated with re... | Neurology & Cognition | Strong | |
| rs16147 | NPY C-399T | Promoter variant in neuropeptide Y that modulates NPY expression under stress... | Mood & Behavior | Moderate | |
| rs2815752 | NEGR1 | Top obesity GWAS variant near NEGR1 | Appetite & Obesity | Strong | |
| rs11558538 | HNMT Thr105Ile | HNMT structural variant - reduces enzyme stability and histamine clearance in... | Methylation & Detox | Strong | |
| rs16969968 | CHRNA5 Asp398Asn | Nicotinic receptor variant strongly associated with heavy smoking, nicotine d... | Mood & Behavior | Established | |
| rs1800497 | DRD2/ANKK1 TaqIA (Glu713Lys) | Reduces dopamine D2 receptor density in the striatum, affecting reward proces... | Mood & Behavior | Strong | |
| rs1800955 | DRD4 -521C>T | Promoter variant that modulates dopamine D4 receptor expression in the prefro... | Mood & Behavior | Moderate | |
| rs2023239 | CNR1 | Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1... | Mood & Behavior | Moderate | |
| rs2036527 | CHRNA5/CHRNA3 | Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr... | Mood & Behavior | Strong | |
| rs1799971 | OPRM1 A118G | Mu-opioid receptor variant affecting opioid response and pain sensitivity | Pharmacogenomics | Strong | |
| rs2522833 | PCLO Ser4814Ala | Missense variant in the C2A calcium-binding domain of presynaptic scaffolding... | Mood & Behavior | Moderate | |
| rs25531 | SLC6A4 A>G | Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and... | Mood & Behavior | Moderate | |
| rs279858 | GABRA2 K132K | GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ... | Mood & Behavior | Strong | |
| rs225014 | DIO2 Thr92Ala | Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pitu... | Hormones & Sleep | Strong | |
| rs324420 | FAAH Pro129Thr | Affects anandamide levels through altered FAAH enzyme stability, influencing ... | Mood & Behavior | Strong | |
| rs4570625 | TPH2 G-703T | Promoter variant affecting brain serotonin synthesis enzyme; influences emoti... | Mood & Behavior | Moderate | |
| rs4654748 | NBPF3 | Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti... | Vitamins & Nutrient Absorption | Strong | |
| rs53576 | OXTR Intronic A>G | Most-studied oxytocin receptor variant, influencing empathy, social sensitivi... | Mood & Behavior | Moderate | |
| rs588765 | CHRNA5 5' UTR / Locus 3 | Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres... | Mood & Behavior | Strong | |
| rs6311 | HTR2A -1438G>A | Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ... | Mood & Behavior | Moderate | |
| rs6323 | MAOA R297R | X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans... | Mood & Behavior | Strong | |
| rs6454674 | CNR1 Near gene (SNP3) | Intronic variant in the cannabinoid receptor 1 gene that modulates substance ... | Mood & Behavior | Moderate | |
| rs17518584 | CADM2 | Intronic CADM2 variant genome-wide significant for information processing spe... | Neurology & Cognition | Moderate | |
| rs8034191 | AGPHD1/CHRNA3 15q25.1 intergenic | Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re... | Mood & Behavior | Strong | |
| rs4446909 | ASMT Promoter A>G | Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression... | Hormones & Sleep | Moderate | |
| rs806368 | CNR1 | 3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio... | Mood & Behavior | Moderate | |
| rs4746 | GLO1 Glu111Ala | Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly... | Hormones & Sleep | Moderate | |
| rs5443 | GNB3 C825T | Synonymous exon-10 variant that triggers alternative splicing of the G-protei... | Hormones & Sleep | Strong | |
| rs391300 | SRR SRR rs391300 | Intronic variant in serine racemase that alters D-serine production in pancre... | Blood Sugar & Diabetes | Moderate | |
| rs5751876 | ADORA2A 1976T>C | Adenosine A2A receptor variant that determines individual sensitivity to caff... | Hormones & Sleep | Strong | |
| rs387907200 | SPR | Missense/splicing variant in sepiapterin reductase that reduces BH4 biosynthe... | Methylation & Detox | Strong | |
| rs4680 | COMT Val158Met | Dopamine/catecholamine breakdown — affects stress response and methyl donor t... | Methylation & Detox | Established | |
| rs7895833 | SIRT1 A>G | Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ... | Longevity & Aging | Moderate | |
| rs2653349 | HCRTR2 Ile308Val | Missense variant at position 308 of the orexin receptor 2 protein; the minor ... | Neurology & Cognition | Strong | |
| rs4532 | DRD1 | Regulatory 5'UTR variant in the dopamine D1 receptor gene influencing recepto... | Neurology & Cognition | Moderate | |
| rs6746030 | SCN9A R1150W | Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa... | Neurology & Cognition | Strong | |
| rs6777055 | CACNA2D3 | Intronic variant affecting thermal pain sensitivity and central pain signal t... | Neurology & Cognition | Moderate | |
| rs6795209 | HTR1F | Intergenic variant at the HTR1F locus on chromosome 3; the minor A allele inc... | Neurology & Cognition | Strong | |
| rs8007267 | GCH1 | Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi... | Neurology & Cognition | Strong | |
| rs8065080 | TRPV1 Ile585Val | Capsaicin receptor variant affecting heat and pain sensitivity | Neurology & Cognition | Strong |