Tag

Neurotransmitters

39 genetic variants with this tag.

RSID	Gene	Description	Category
rs225014	DIO2 Thr92Ala	Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pitu...	Hormones & Sleep	Hormones & Thyroid Neurotransmitters Metabolism	Strong
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Brain & Mental Health	Dopamine Cognition Neurotransmitters	Strong
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Longevity & Aging	Mental Health Longevity Cardiovascular	Strong
rs1800955	DRD4 -521C>T	Promoter variant that modulates dopamine D4 receptor expression in the prefro...	Brain & Mental Health	Cognition Dopamine Neurotransmitters	Moderate
rs1611115	DBH -1021C>T	Strongest known genetic determinant of dopamine beta-hydroxylase activity, co...	Brain & Mental Health	Cognition Dopamine Neurotransmitters	Strong
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Mental Health Neurotransmitters Cardiovascular	Moderate
rs53576	OXTR Intronic A>G	Most-studied oxytocin receptor variant, influencing empathy, social sensitivi...	Brain & Mental Health	Cognition Empathy Stress	Moderate
rs4570625	TPH2 G-703T	Promoter variant affecting brain serotonin synthesis enzyme; influences emoti...	Brain & Mental Health	Mental Health Neurotransmitters Depression	Moderate
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Brain & Mental Health	Mental Health Antidepressants Neurotransmitters	Moderate
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs279858	GABRA2 K132K	GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ...	Brain & Mental Health	Mental Health Alcohol Anxiety	Strong
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Methylation Neurotransmitters Detoxification	Established
rs324420	FAAH Pro129Thr	Affects anandamide levels through altered FAAH enzyme stability, influencing ...	Brain & Mental Health	Mental Health Neurotransmitters Pain Management	Strong
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Sleep Melatonin Circadian	Moderate
rs524952	GJD2	Intergenic variant near GJD2 affecting myopia risk and axial eye growth throu...	Skin & Eyes	Eye Health Vision Neurotransmitters	Strong
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Brain & Mental Health	Mental Health Neurotransmitters Mood	Strong
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Brain & Mental Health	Mental Health Neurotransmitters Antidepressants	Moderate
rs5751876	ADORA2A 1976T>C	Adenosine A2A receptor variant that determines individual sensitivity to caff...	Hormones & Sleep	Sleep Caffeine Anxiety	Strong
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Brain & Mental Health	Mental Health Addiction Smoking	Established
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension Blood Pressure Antidepressants	Strong
rs1050891	HNMT 3'UTR variant	Histamine breakdown in blood and tissues - uses methyl groups from SAM	Methylation & Detox	Histamine Methylation Detoxification	Moderate
rs11558538	HNMT Thr105Ile	HNMT structural variant - reduces enzyme stability and histamine clearance in...	Methylation & Detox	Histamine Methylation Detoxification	Strong
rs1799971	OPRM1 A118G	Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p...	Pharmacogenomics	Drug Metabolism Pain Medication Addiction	Moderate
rs6746030	SCN9A R1150W	Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa...	Brain & Mental Health	Pain Sensitivity Neurotransmitters Anesthesia	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Brain & Mental Health	Pain Sensitivity Neurotransmitters Cardiovascular	Strong
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Brain & Mental Health	Pain Sensitivity Nitric Oxide Neurotransmitters	Strong
rs6777055	CACNA2D3	Intronic variant affecting thermal pain sensitivity and central pain signal t...	Brain & Mental Health	Pain Sensitivity Neurotransmitters Sensory Processing	Moderate
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Brain & Mental Health	Stress Response Appetite Obesity	Moderate
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Brain & Mental Health	Serotonin Neurotransmitters Mental Health	Moderate
rs806368	CNR1	3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio...	Brain & Mental Health	Addiction Neurotransmitters Brain Health	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Nutrition & Metabolism	Obesity Appetite Diet	Moderate
rs1049353	CNR1 3'UTR (G1359A)	Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp...	Brain & Mental Health	Endocannabinoid Addiction Stress Response	Moderate
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Brain & Mental Health	Mental Health Addiction Smoking	Established
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Nutrition & Metabolism	Obesity Appetite Diet	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Nutrition & Metabolism	Obesity Appetite Diabetes	Moderate
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Brain & Mental Health	Mental Health Addiction Smoking	Strong
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Brain & Mental Health	Mental Health Addiction Smoking	Strong
rs4654748	NBPF3	Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...	Nutrition & Metabolism	B Vitamins Homocysteine Neurotransmitters	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Nutrition & Metabolism	Obesity Appetite Neurotransmitters	Strong