Tag

Neurotransmitters

76 genetic variants with this tag.

RSID	Gene	Description	Category
rs1003194	CALCA/CALCB	Intergenic regulatory variant ~26 kb downstream of CALCB (calcitonin gene-rel...	Neurology & Cognition	Neurotransmitters	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Appetite & Obesity	Neurotransmitters	Strong
rs10038916	GRIA1	Intronic variant in the AMPA glutamate receptor gene GRIA1 associated with re...	Neurology & Cognition	Neurotransmitters	Strong
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Appetite & Obesity	Neurotransmitters	Moderate
rs104893665	SPR Arg150Gly	Pathogenic missense variant in sepiapterin reductase that abolishes BH4 biosy...	Vitamins & Nutrient Absorption	Neurotransmitters	Established
rs1049353	CNR1 3'UTR (G1359A)	Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp...	Mood & Behavior	Neurotransmitters	Moderate
rs10483099	QDPR	Intronic variant near QDPR that affects BH4 recycling efficiency, influencing...	Methylation & Detox	Neurotransmitters	Emerging
rs1051730	CHRNA3 Tyr215Tyr	CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass...	Mood & Behavior	Neurotransmitters	Established
rs1019385	GRIN2B	Promoter variant in the GRIN2B Sp1 binding site that reduces NR2B subunit exp...	Neurology & Cognition	Neurotransmitters	Moderate
rs10786831	SORCS3 SORCS3 Depression Variant	Intronic variant in the neurotrophin sorting receptor SORCS3, the top GWAS hi...	Mood & Behavior	Neurotransmitters	Strong
rs121917746	SPR Q119X	Nonsense variant in sepiapterin reductase that abolishes BH4 biosynthesis, ca...	Vitamins & Nutrient Absorption	Neurotransmitters	Established
rs10947690	MDGA1 Leu61Pro	Missense variant in the inhibitory synapse regulator MDGA1 that impairs neuro...	Hormones & Sleep	Neurotransmitters	Strong
rs11599236	SORCS3 SORCS3 Neurotrophin Sorting	Intronic variant in the BDNF-receptor trafficking gene SORCS3, associated wit...	Mood & Behavior	Neurotransmitters	Strong
rs121917747	SPR	Nonsense variant in sepiapterin reductase creating a premature stop codon (p....	Vitamins & Nutrient Absorption	Neurotransmitters	Established
rs12624433	SLC12A5 KCC2 Chloride Transport	Intronic variant in SLC12A5 reducing KCC2 potassium-chloride cotransporter fu...	Mood & Behavior	Neurotransmitters	Moderate
rs1050891	HNMT 3'UTR variant	Histamine breakdown in blood and tissues - uses methyl groups from SAM	Methylation & Detox	Neurotransmitters	Moderate
rs1387923	NTRK2 NTRK2/TrkB 3'UTR variant	3' UTR variant in the TrkB receptor gene affecting NTRK2 expression; associat...	Mood & Behavior	Neurotransmitters	Moderate
rs10839553	CCKBR	Intronic variant near the cholecystokinin B receptor gene associated with res...	Neurology & Cognition	Neurotransmitters	Strong
rs1545843	SLC6A15 SLC6A15 depression risk variant	Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show...	Mood & Behavior	Neurotransmitters	Strong
rs10895816	GRIA4	Intronic variant in the AMPA glutamate receptor gene GRIA4 associated with re...	Neurology & Cognition	Neurotransmitters	Strong
rs1611115	DBH -1021C>T	Strongest known genetic determinant of dopamine beta-hydroxylase activity, co...	Mood & Behavior	Neurotransmitters	Strong
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Mood & Behavior	Neurotransmitters	Moderate
rs11713169	NLGN1	Intronic variant in neuroligin 1, a postsynaptic cell adhesion molecule essen...	Neurology & Cognition	Neurotransmitters	Strong
rs16969968	CHRNA5 Asp398Asn	Nicotinic receptor variant strongly associated with heavy smoking, nicotine d...	Mood & Behavior	Neurotransmitters	Established
rs1800497	DRD2/ANKK1 TaqIA (Glu713Lys)	Reduces dopamine D2 receptor density in the striatum, affecting reward proces...	Mood & Behavior	Neurotransmitters	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Appetite & Obesity	Neurotransmitters	Moderate
rs1800883	HTR5A	Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep...	Mood & Behavior	Neurotransmitters	Moderate
rs1800955	DRD4 -521C>T	Promoter variant that modulates dopamine D4 receptor expression in the prefro...	Mood & Behavior	Neurotransmitters	Moderate
rs2023239	CNR1	Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1...	Mood & Behavior	Neurotransmitters	Moderate
rs11558538	HNMT Thr105Ile	HNMT structural variant - reduces enzyme stability and histamine clearance in...	Methylation & Detox	Neurotransmitters	Strong
rs2036527	CHRNA5/CHRNA3	Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr...	Mood & Behavior	Neurotransmitters	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Appetite & Obesity	Neurotransmitters	Strong
rs17679445	PNPO Arg116Gln	Missense variant in pyridoxamine 5'-phosphate oxidase that reduces the enzyme...	Hormones & Sleep	Neurotransmitters	Moderate
rs524952	GJD2	Intergenic variant near GJD2 affecting myopia risk and axial eye growth throu...	Skin & Eyes	Neurotransmitters	Strong
rs2371365	PCLO PCLO Presynaptic Scaffold	Intronic variant in the presynaptic scaffold gene PCLO linked to altered mono...	Mood & Behavior	Neurotransmitters	Moderate
rs2522833	PCLO Ser4814Ala	Missense variant in the C2A calcium-binding domain of presynaptic scaffolding...	Mood & Behavior	Neurotransmitters	Moderate
rs1799971	OPRM1 A118G	Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p...	Pharmacogenomics	Neurotransmitters	Strong
rs25531	SLC6A4 A>G	Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and...	Mood & Behavior	Neurotransmitters	Moderate
rs279858	GABRA2 K132K	GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ...	Mood & Behavior	Neurotransmitters	Strong
rs324420	FAAH Pro129Thr	Affects anandamide levels through altered FAAH enzyme stability, influencing ...	Mood & Behavior	Neurotransmitters	Strong
rs4395923	CYP7B1 CYP7B1 Neurosteroid Hydroxylase	Intronic variant in the brain neurosteroid hydroxylase gene affecting DHEA an...	Mood & Behavior	Neurotransmitters	Emerging
rs17518584	CADM2	Intronic CADM2 variant genome-wide significant for information processing spe...	Neurology & Cognition	Neurotransmitters	Moderate
rs4570625	TPH2 G-703T	Promoter variant affecting brain serotonin synthesis enzyme; influences emoti...	Mood & Behavior	Neurotransmitters	Moderate
rs53576	OXTR Intronic A>G	Most-studied oxytocin receptor variant, influencing empathy, social sensitivi...	Mood & Behavior	Neurotransmitters	Moderate
rs225014	DIO2 Thr92Ala	Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pitu...	Hormones & Sleep	Neurotransmitters	Strong
rs4654748	NBPF3	Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...	Vitamins & Nutrient Absorption	Neurotransmitters	Strong
rs578776	CHRNA3 3' UTR	CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10...	Mood & Behavior	Neurotransmitters	Strong
rs588765	CHRNA5 5' UTR / Locus 3	Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres...	Mood & Behavior	Neurotransmitters	Strong
rs6295	HTR1A C-1019G	Functional promoter variant in the serotonin 1A receptor gene that increases ...	Mood & Behavior	Neurotransmitters	Strong
rs6311	HTR2A -1438G>A	Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ...	Mood & Behavior	Neurotransmitters	Moderate
rs6323	MAOA R297R	X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans...	Mood & Behavior	Neurotransmitters	Strong
rs2304672	PER2 5'UTR C111G	Regulatory variant in a core clock gene that influences circadian timing, sle...	Hormones & Sleep	Neurotransmitters	Moderate
rs6454674	CNR1 Near gene (SNP3)	Intronic variant in the cannabinoid receptor 1 gene that modulates substance ...	Mood & Behavior	Neurotransmitters	Moderate
rs2325751	PNPO	Regulatory variant 2 kb upstream of PNPO that may alter expression of the vit...	Hormones & Sleep	Neurotransmitters	Emerging
rs73034295	IGSF9B IGSF9B Inhibitory Synapse Adhesion	Intronic variant in the gene encoding the inhibitory synaptic adhesion protei...	Mood & Behavior	Neurotransmitters	Emerging
rs8034191	AGPHD1/CHRNA3 15q25.1 intergenic	Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re...	Mood & Behavior	Neurotransmitters	Strong
rs806368	CNR1	3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio...	Mood & Behavior	Neurotransmitters	Moderate
rs2274319	MEF2D	Intronic variant in MEF2D encoding a key neuronal transcription factor that r...	Neurology & Cognition	Neurotransmitters	Strong
rs2653349	HCRTR2 Ile308Val	Missense variant at position 308 of the orexin receptor 2 protein; the minor ...	Neurology & Cognition	Neurotransmitters	Strong
rs391300	SRR SRR rs391300	Intronic variant in serine racemase that alters D-serine production in pancre...	Blood Sugar & Diabetes	Neurotransmitters	Moderate
rs4446909	ASMT Promoter A>G	Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression...	Hormones & Sleep	Neurotransmitters	Moderate
rs4746	GLO1 Glu111Ala	Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly...	Hormones & Sleep	Neurotransmitters	Moderate
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Neurotransmitters	Moderate
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Longevity & Aging	Neurotransmitters	Strong
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Neurotransmitters	Strong
rs387907200	SPR	Missense/splicing variant in sepiapterin reductase that reduces BH4 biosynthe...	Methylation & Detox	Neurotransmitters	Strong
rs5751876	ADORA2A 1976T>C	Adenosine A2A receptor variant that determines individual sensitivity to caff...	Hormones & Sleep	Neurotransmitters	Strong
rs4680	COMT Val158Met	Dopamine/catecholamine breakdown — affects stress response and methyl donor t...	Methylation & Detox	Neurotransmitters	Established
rs4532	DRD1	Regulatory 5'UTR variant in the dopamine D1 receptor gene influencing recepto...	Neurology & Cognition	Neurotransmitters	Moderate
rs9479402	VIP VIP chronotype variant	Intergenic variant ~54 kb downstream of the VIP gene; the C allele reduces VI...	Hormones & Sleep	Neurotransmitters	Strong
rs6746030	SCN9A R1150W	Common variant in the Nav1.7 sodium channel affecting pain sensitivity and pa...	Neurology & Cognition	Neurotransmitters	Strong
rs6777055	CACNA2D3	Intronic variant affecting thermal pain sensitivity and central pain signal t...	Neurology & Cognition	Neurotransmitters	Moderate
rs6795209	HTR1F	Intergenic variant at the HTR1F locus on chromosome 3; the minor A allele inc...	Neurology & Cognition	Neurotransmitters	Strong
rs6833641	ARAP2	Intergenic variant near ARAP2 associated with motion sickness susceptibility ...	Neurology & Cognition	Neurotransmitters	Strong
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Neurology & Cognition	Neurotransmitters	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Neurology & Cognition	Neurotransmitters	Strong