Tag

Obesity

41 genetic variants with this tag.

RSID	Gene	Description	Category
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Nutrition & Metabolism	Diabetes Insulin Diet	Established
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Hypertension Blood Pressure Antidepressants	Strong
rs2241766	ADIPOQ T45G	Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability...	Heart & Inflammation	Fat Metabolism Obesity Insulin	Moderate
rs6905288	VEGFA	Adipose tissue vascularization variant near VEGFA influencing fat distributio...	Heart & Inflammation	Fat Metabolism Cardiovascular Insulin	Moderate
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs6923761	GLP1R Gly168Ser	GLP-1 receptor variant that alters response to GLP-1 agonist medications used...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs3765467	GLP1R Arg131Gln	Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs1042044	GLP1R Leu260Phe	GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e...	Pharmacogenomics	Drug Response Pharmacogenomics Obesity	Moderate
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Nutrition & Metabolism	Nutrition & Metabolism Insulin Diabetes	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant affecting satiety signaling and metabolic health	Nutrition & Metabolism	Nutrition & Metabolism Obesity Diabetes	Moderate
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Brain & Mental Health	Stress Response Appetite Obesity	Moderate
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs1800592	UCP1 A-3826G	Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Strong
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Nutrition & Metabolism	Leptin Satiety Obesity	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Nutrition & Metabolism	Obesity Appetite Diet	Moderate
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Nutrition & Metabolism	Obesity Fat Metabolism Diet	Moderate
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Nutrition & Metabolism	Obesity Appetite Metabolic Syndrome	Moderate
rs9491696	RSPO3	Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin Resistance	Strong
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Strong
rs2651899	PRDM16	Intronic variant in the master regulator of brown/beige fat differentiation, ...	Nutrition & Metabolism	Fat Metabolism Thermogenesis Cardiovascular	Moderate
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Nutrition & Metabolism	Obesity Appetite Fat Metabolism	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Nutrition & Metabolism	Obesity Appetite Diet	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Nutrition & Metabolism	Obesity Appetite Diabetes	Moderate
rs6947337	INHBA	Activin A signaling variant near INHBA linking adipocyte dysfunction to share...	Nutrition & Metabolism	Obesity Fat Metabolism Inflammation	Moderate
rs29941	KCTD15	GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...	Nutrition & Metabolism	Obesity Fat Metabolism Adipogenesis	Moderate
rs7647305	ETV5	GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...	Nutrition & Metabolism	Obesity Appetite Dopamine	Moderate
rs10838738	MTCH2	Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance...	Nutrition & Metabolism	Obesity Mitochondria Energy Metabolism	Moderate
rs987237	TFAP2B	Adipocyte transcription factor variant influencing central fat distribution a...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Moderate
rs1776897	HMGA1	Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2241423	MAP2K5	MAPK signaling variant in MAP2K5 associated with BMI through altered adipogen...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Nutrition & Metabolism	Obesity Metabolic Fat Metabolism	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Nutrition & Metabolism	Obesity Leptin Insulin Resistance	Strong
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Nutrition & Metabolism	Obesity Satiety Appetite	Strong
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Nutrition & Metabolism	Obesity Appetite Neurotransmitters	Strong