Tag

Obesity

100 genetic variants with this tag.

RSID	Gene	Description	Category
rs10150332	NRXN3	Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna...	Appetite & Obesity	Obesity	Strong
rs10305420	GLP1R Pro7Leu	GLP-1 receptor signal peptide variant that enhances semaglutide and tirzepati...	Pharmacogenomics	Obesity	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Appetite & Obesity	Obesity	Moderate
rs10515237	PCSK1 PCSK1 A/G (rs10515237)	Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype, red...	Appetite & Obesity	Obesity	Moderate
rs1064608	MTCH2 Pro290Ala	Missense variant in MTCH2 that reduces mitochondrial metabolic efficiency, in...	Hormones & Sleep	Obesity	Moderate
rs1042044	GLP1R Leu260Phe	GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e...	Pharmacogenomics	Obesity	Moderate
rs10766383	NUCB2	Intronic NUCB2 variant associated with type 2 diabetes risk in females and or...	Hormones & Sleep	Obesity	Moderate
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Appetite & Obesity	Obesity	Strong
rs1044498	ENPP1 K121Q	ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece...	Blood Sugar & Diabetes	Obesity	Strong
rs10838738	MTCH2	Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance...	Appetite & Obesity	Obesity	Moderate
rs10852521	FTO	FTO intron 1 variant associated with BMI and body fat accumulation, with stro...	Fitness & Body	Obesity	Moderate
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Appetite & Obesity	Obesity	Strong
rs1776897	HMGA1	Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an...	Liver Fat	Obesity	Moderate
rs10882283	RBP4 RBP4 rs10882283	5' UTR variant in RBP4 that influences expression of retinol binding protein ...	Fat Storage & Energy	Obesity	Moderate
rs11037909	EXT2	Intronic EXT2 variant associated with a modest increase in type 2 diabetes su...	Appetite & Obesity	Obesity	Moderate
rs1108086	FTO FTO Intron 8 T>C	An FTO intron-8 variant in the same haplotype block as rs1420318, with emergi...	Fitness & Body	Obesity	Emerging
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant in the leptin-binding domain affecting satiety...	Hormones & Sleep	Obesity	Moderate
rs11152221	MC4R MC4R Proximal LD Block Variant	Intergenic variant in the proximal 3' regulatory block near MC4R associated w...	Appetite & Obesity	Obesity	Strong
rs11644943	FTO FTO Mid-Gene Intron Variant	An intronic FTO variant outside the well-known intron-1 obesity cluster; the ...	Appetite & Obesity	Obesity	Emerging
rs12970134	MC4R MC4R region variant	Near-gene variant ~188kb downstream of MC4R associated with increased waist c...	Appetite & Obesity	Obesity	Strong
rs13407913	ADCY3	Intronic variant in the adenylyl cyclase 3 gene, which encodes a cAMP-produci...	Fitness & Body	Obesity	Emerging
rs1420318	FTO	FTO intron 8 variant associated with nominal spine bone mineral density effec...	Fitness & Body	Obesity	Emerging
rs16147	NPY C-399T	Promoter variant in neuropeptide Y that modulates NPY expression under stress...	Mood & Behavior	Obesity	Moderate
rs1175540	PPARG PPARG rs1175540	Intronic PPARG variant associated with differential weight loss response to c...	Fat Storage & Energy	Obesity	Moderate
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Appetite & Obesity	Obesity	Strong
rs1330	NUCB2	Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes...	Hormones & Sleep	Obesity	Moderate
rs1800544	ADRA2A ADRA2A Promoter -1291C>G	Promoter variant that alters alpha-2A adrenergic receptor expression, affecti...	Appetite & Obesity	Obesity	Moderate
rs1175544	PPARG PPARG rs1175544	Intronic PPARG variant that accounts for ~7% of individual variation in body ...	Fat Storage & Energy	Obesity	Emerging
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Appetite & Obesity	Obesity	Moderate
rs12094543	ZMYM4 ZMYM4 rs12094543	Intronic variant in ZMYM4, a chromatin-remodeling transcription factor whose ...	Fat Storage & Energy	Obesity	Emerging
rs17219084	FTO	FTO intron variant in the extended obesity-associated region, with explorator...	Fitness & Body	Obesity	Emerging
rs1943226	MC4R MC4R third tagSNP	Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl...	Appetite & Obesity	Obesity	Emerging
rs11705701	IGF2BP2 IGF2BP2 Insulin Signaling Variant	Upstream regulatory variant in IGF2BP2 that shifts mRNA isoform balance in ad...	Blood Sugar & Diabetes	Obesity	Moderate
rs2229616	MC4R V103I	Missense variant in MC4R converting valine to isoleucine at position 103; the...	Appetite & Obesity	Obesity	Strong
rs1554483	CLOCK	Intronic CLOCK variant whose G allele, in a haplotype with rs4864548 A, confe...	Hormones & Sleep	Obesity	Moderate
rs2241423	MAP2K5	MAPK signaling variant in MAP2K5 associated with BMI through altered adipogen...	Appetite & Obesity	Obesity	Moderate
rs6536991	UCP1	Intronic UCP1 variant — the C allele is associated with reduced overweight ri...	Liver Fat	Obesity	Emerging
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Appetite & Obesity	Obesity	Strong
rs2241766	ADIPOQ T45G	Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability...	Coronary Artery Disease & Atherosclerosis	Obesity	Moderate
rs2867125	TMEM18 TMEM18 regulatory variant (2p25.3)	Regulatory variant at the TMEM18 locus on chromosome 2p25.3 — one of the most...	Appetite & Obesity	Obesity	Strong
rs2922126	GHSR GHSR A/G (rs2922126)	Upstream regulatory variant near the ghrelin receptor gene; the A allele is a...	Appetite & Obesity	Obesity	Moderate
rs29941	KCTD15	GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri...	Appetite & Obesity	Obesity	Moderate
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Appetite & Obesity	Obesity	Moderate
rs2568958	NEGR1 NEGR1 depression/BMI variant	Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi...	Mood & Behavior	Obesity	Strong
rs476828	MC4R MC4R-region BMI variant	Intergenic variant in the MC4R regulatory haplotype block, tagging the same a...	Appetite & Obesity	Obesity	Strong
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Fat Storage & Energy	Obesity	Strong
rs4788102	SH2B1 SH2B1/APOBR locus variant	Intronic variant at the SH2B1 locus on chromosome 16p11.2 — a key adaptor pro...	Appetite & Obesity	Obesity	Strong
rs1797912	PPARG PPARG intronic haplotype variant	Intronic PPARG variant in the same haplotype block as rs1175543; the C allele...	Fat Storage & Energy	Obesity	Emerging
rs489693	MC4R MC4R AIWG variant	Intergenic variant near MC4R with genome-wide significant association with an...	Appetite & Obesity	Obesity	Strong
rs1800592	UCP1 A-3826G	Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...	Fat Storage & Energy	Obesity	Moderate
rs490683	GHSR GHSR Promoter NF-1 Site Variant	Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio...	Appetite & Obesity	Obesity	Moderate
rs509035	GHSR GHSR Metabolic Syndrome Variant	Intronic variant in the ghrelin receptor gene; the A allele is associated wit...	Appetite & Obesity	Obesity	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Fat Storage & Energy	Obesity	Established
rs571312	MC4R MC4R Regulatory Variant (Appetite Signaling)	Regulatory variant upstream of MC4R associated with increased caloric intake,...	Appetite & Obesity	Obesity	Strong
rs6232	PCSK1 PCSK1 N221D (Asn221Asp)	Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca...	Appetite & Obesity	Obesity	Strong
rs6234	PCSK1 PCSK1 Q665E (Gln665Glu)	Missense variant in PCSK1 that causes a Gln665Glu substitution in the C-termi...	Appetite & Obesity	Obesity	Strong
rs6235	PCSK1 PCSK1 S690T (Ser690Thr)	Missense variant encoding the Ser690Thr substitution in the C-terminal domain...	Appetite & Obesity	Obesity	Strong
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Appetite & Obesity	Obesity	Strong
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Fat Storage & Energy	Obesity	Moderate
rs6947337	INHBA	Activin A signaling variant near INHBA linking adipocyte dysfunction to share...	Appetite & Obesity	Obesity	Moderate
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Fat Storage & Energy	Obesity	Strong
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Appetite & Obesity	Obesity	Moderate
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Obesity	Strong
rs2651899	PRDM16	Intronic variant in the master regulator of brown/beige fat differentiation, ...	Fat Storage & Energy	Obesity	Moderate
rs6905288	VEGFA	Adipose tissue vascularization variant near VEGFA influencing fat distributio...	Vascular Inflammation & Remodeling	Obesity	Moderate
rs7359397	SH2B1 SH2B1 C/T	Regulatory CpG-SNP downstream of SH2B1 that reduces gene expression via allel...	Appetite & Obesity	Obesity	Moderate
rs266729	ADIPOQ -11391G>C	Promoter variant reducing adiponectin transcription, increasing T2D, NAFLD, a...	Fat Storage & Energy	Obesity	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Appetite & Obesity	Obesity	Strong
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Appetite & Obesity	Obesity	Moderate
rs2920502	PPARG PPARG rs2920502	Intronic PPARG variant associated with body fat percentage, impaired glucose ...	Fat Storage & Energy	Obesity	Moderate
rs7647305	ETV5	GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f...	Appetite & Obesity	Obesity	Moderate
rs2959272	PPARG PPARG intronic calorie-restriction trial variant	Intronic PPARG variant significantly associated with individual variation in ...	Fat Storage & Energy	Obesity	Emerging
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Appetite & Obesity	Obesity	Moderate
rs8087522	MC4R MC4R A/G (rs8087522)	Upstream regulatory variant near MC4R that may create a transcription factor ...	Appetite & Obesity	Obesity	Emerging
rs62623713	SYPL2 E99G	Low-frequency missense variant in SYPL2 associated with morbid obesity suscep...	Fitness & Body	Obesity	Emerging
rs9819506	GHSR GHSR Promoter Variant (Ghrelin Receptor Signaling)	Promoter-region tag SNP in the ghrelin receptor gene associated with body wei...	Appetite & Obesity	Obesity	Moderate
rs3212018	CD36	A 16-bp deletion in the 3' untranslated region of CD36 that may reduce mRNA s...	Triglycerides & Fatty Acids	Obesity	Emerging
rs3745012	LPIN2 LPIN2 3'UTR variant	3' UTR regulatory variant in LPIN2 (lipin 2) that alters fat distribution and...	Fat Storage & Energy	Obesity	Moderate
rs987237	TFAP2B	Adipocyte transcription factor variant influencing central fat distribution a...	Appetite & Obesity	Obesity	Moderate
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Appetite & Obesity	Obesity	Established
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Blood Sugar & Diabetes	Obesity	Strong
rs4684847	PPARG PPARG cis-regulatory variant (PR domain recruitment)	Intronic cis-regulatory PPARG variant where the C allele recruits PR domain r...	Fat Storage & Energy	Obesity	Moderate
rs4684854	PPARG	Intergenic regulatory variant downstream of PPARG associated with central obe...	Fat Storage & Energy	Obesity	Emerging
rs367643250	DYRK1B R102C	Rare gain-of-function variant causing autosomal dominant metabolic syndrome (...	Blood Sugar & Diabetes	Obesity	Strong
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Fat Storage & Energy	Obesity	Moderate
rs3787348	PTPN1 PTPN1 intronic variant	Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ...	Blood Sugar & Diabetes	Obesity	Moderate
rs5181	LRP8 Trp466Cys	Rare missense variant in the ApoE receptor 2 (LRP8) ligand-binding domain, di...	Fat Storage & Energy	Obesity	Emerging
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Fat Storage & Energy	Obesity	Moderate
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Triglycerides & Fatty Acids	Obesity	Strong
rs5085	APOA2 APOA2 rs5085	Intronic APOA2 tag SNP that captures the saturated fat-weight gain interactio...	Triglycerides & Fatty Acids	Obesity	Strong
rs6954668	SFRP5 SFRP5 Wnt5a inhibitor variant	Intergenic variant near the SFRP5 adipokine locus; the A allele is strongly e...	Fat Storage & Energy	Obesity	Emerging
rs3765467	GLP1R Arg131Gln	Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago...	Pharmacogenomics	Obesity	Moderate
rs692383	ABCG1 ABCG1 HDL-c Variant	Intronic variant in the ABCG1 cholesterol efflux transporter gene associated ...	Triglycerides & Fatty Acids	Obesity	Emerging
rs5443	GNB3 C825T	Synonymous exon-10 variant that triggers alternative splicing of the G-protei...	Hormones & Sleep	Obesity	Strong
rs9491696	RSPO3	Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt...	Fat Storage & Energy	Obesity	Strong
rs587777380	DYRK1B H90P / H90R	Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the D...	Blood Sugar & Diabetes	Obesity	Strong
rs757081	NUCB2 Gln338Glu (Q338E)	Missense variant in nucleobindin-2, the precursor protein cleaved to produce ...	Hormones & Sleep	Obesity	Moderate
rs6067484	PTPN1 PTPN1 rs6067484	Intronic PTPN1 tag SNP within the 100-kb T2D-risk haplotype block — carriers ...	Blood Sugar & Diabetes	Obesity	Moderate
rs914458	PTPN1 PTPN1 downstream variant	Downstream regulatory variant 10 kb 3' of PTPN1 (PTP1B) associated with type ...	Blood Sugar & Diabetes	Obesity	Emerging
rs6923761	GLP1R Gly168Ser	GLP-1 receptor variant that alters response to GLP-1 agonist medications used...	Pharmacogenomics	Obesity	Moderate