Tag
Obesity
56 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10150332 | NRXN3 | Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna... | Appetite & Obesity | Strong | |
| rs10305420 | GLP1R Pro7Leu | GLP-1 receptor signal peptide variant that enhances semaglutide and tirzepati... | Pharmacogenomics | Moderate | |
| rs10515237 | PCSK1 PCSK1 A/G (rs10515237) | Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype | Appetite & Obesity | Moderate | |
| rs10766383 | NUCB2 | Intronic NUCB2 variant associated with type 2 diabetes risk in females and or... | Hormones & Sleep | Moderate | |
| rs10838738 | MTCH2 | Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance... | Appetite & Obesity | Moderate | |
| rs10882283 | RBP4 RBP4 rs10882283 | 5' UTR variant in RBP4 that influences expression of retinol binding protein ... | Fat Storage & Energy | Moderate | |
| rs1042044 | GLP1R Leu260Phe | GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e... | Pharmacogenomics | Moderate | |
| rs1044498 | ENPP1 K121Q | ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece... | Blood Sugar & Diabetes | Strong | |
| rs10938397 | GNPDA2 | GIANT consortium GWAS obesity locus near GNPDA2 | Appetite & Obesity | Strong | |
| rs1108086 | FTO FTO Intron 8 T>C | An FTO intron-8 variant in the same haplotype block as rs1420318, with emergi... | Fitness & Body | Emerging | |
| rs1137101 | LEPR Q223R (Gln223Arg) | Common leptin receptor variant in the leptin-binding domain affecting satiety... | Hormones & Sleep | Moderate | |
| rs1776897 | HMGA1 | Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an... | Liver Fat | Moderate | |
| rs11152221 | MC4R MC4R Proximal LD Block Variant | Intergenic variant in the proximal 3' regulatory block near MC4R associated w... | Appetite & Obesity | Strong | |
| rs1175544 | PPARG PPARG rs1175544 | Intronic PPARG variant that accounts for ~7% of individual variation in body ... | Fat Storage & Energy | Emerging | |
| rs12970134 | MC4R MC4R region variant | Near-gene variant ~188kb downstream of MC4R associated with increased waist c... | Appetite & Obesity | Strong | |
| rs1420318 | FTO | FTO intron 8 variant associated with nominal spine bone mineral density effec... | Fitness & Body | Emerging | |
| rs17782313 | MC4R Near-gene C>T | Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me... | Appetite & Obesity | Strong | |
| rs1943226 | MC4R MC4R third tagSNP | Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl... | Appetite & Obesity | Emerging | |
| rs2229616 | MC4R V103I | Missense variant in MC4R converting valine to isoleucine at position 103; the... | Appetite & Obesity | Strong | |
| rs16147 | NPY C-399T | Promoter variant in neuropeptide Y that modulates NPY expression under stress... | Mood & Behavior | Moderate | |
| rs2815752 | NEGR1 | Top obesity GWAS variant near NEGR1 | Appetite & Obesity | Strong | |
| rs17300539 | ADIPOQ -11391G>A | Promoter variant affecting adiponectin secretion and metabolic syndrome risk | Fat Storage & Energy | Strong | |
| rs2867125 | TMEM18 TMEM18 regulatory variant (2p25.3) | Regulatory variant at the TMEM18 locus on chromosome 2p25.3 — one of the most... | Appetite & Obesity | Strong | |
| rs11705701 | IGF2BP2 IGF2BP2 Insulin Signaling Variant | Upstream regulatory variant in IGF2BP2 that shifts mRNA isoform balance in ad... | Blood Sugar & Diabetes | Moderate | |
| rs1800592 | UCP1 A-3826G | Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ... | Fat Storage & Energy | Moderate | |
| rs29941 | KCTD15 | GWAS obesity locus near KCTD15 | Appetite & Obesity | Moderate | |
| rs6536991 | UCP1 | Intronic UCP1 variant — the C allele is associated with reduced overweight ri... | Liver Fat | Emerging | |
| rs3827103 | MC3R | Common MC3R missense variant that reduces receptor expression and shifts nutr... | Appetite & Obesity | Moderate | |
| rs2304795 | PLIN1 | Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit... | Fat Storage & Energy | Moderate | |
| rs476828 | MC4R MC4R-region BMI variant | Intergenic variant in the MC4R regulatory haplotype block, tagging the same a... | Appetite & Obesity | Strong | |
| rs2651899 | PRDM16 | Intronic variant in the master regulator of brown/beige fat differentiation, ... | Fat Storage & Energy | Moderate | |
| rs4788102 | SH2B1 SH2B1/APOBR locus variant | Intronic variant at the SH2B1 locus on chromosome 16p11.2 — a key adaptor pro... | Appetite & Obesity | Strong | |
| rs489693 | MC4R MC4R AIWG variant | Intergenic variant near MC4R with genome-wide significant association with an... | Appetite & Obesity | Strong | |
| rs2959272 | PPARG PPARG intronic calorie-restriction trial variant | Intronic PPARG variant significantly associated with individual variation in ... | Fat Storage & Energy | Emerging | |
| rs571312 | MC4R MC4R Regulatory Variant (Appetite Signaling) | Regulatory variant upstream of MC4R associated with increased caloric intake,... | Appetite & Obesity | Strong | |
| rs6232 | PCSK1 PCSK1 N221D (Asn221Asp) | Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca... | Appetite & Obesity | Strong | |
| rs3745012 | LPIN2 LPIN2 3'UTR variant | 3' UTR regulatory variant in LPIN2 (lipin 2) that alters fat distribution and... | Fat Storage & Energy | Moderate | |
| rs6905288 | VEGFA | Adipose tissue vascularization variant near VEGFA influencing fat distributio... | Vascular Inflammation & Remodeling | Moderate | |
| rs6548238 | TMEM18 | Second strongest obesity GWAS locus after FTO | Appetite & Obesity | Strong | |
| rs696217 | GHRL Leu72Met | Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel... | Appetite & Obesity | Moderate | |
| rs7498665 | SH2B1 Thr484Ala | Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr... | Appetite & Obesity | Strong | |
| rs7647305 | ETV5 | GWAS obesity locus near ETV5 | Appetite & Obesity | Moderate | |
| rs7799039 | LEP G-2548A | Promoter variant that increases leptin gene expression in adipose tissue, ele... | Appetite & Obesity | Moderate | |
| rs8087522 | MC4R MC4R A/G (rs8087522) | Upstream regulatory variant near MC4R that may create a transcription factor ... | Appetite & Obesity | Emerging | |
| rs62623713 | SYPL2 E99G | Low-frequency missense variant in SYPL2 associated with morbid obesity suscep... | Fitness & Body | Emerging | |
| rs987237 | TFAP2B | Adipocyte transcription factor variant influencing central fat distribution a... | Appetite & Obesity | Moderate | |
| rs2943641 | IRS1 Near-gene C>T | Regulates insulin signaling efficiency and cellular glucose uptake | Blood Sugar & Diabetes | Strong | |
| rs367643250 | DYRK1B R102C | Rare gain-of-function variant causing autosomal dominant metabolic syndrome (... | Blood Sugar & Diabetes | Strong | |
| rs3787348 | PTPN1 PTPN1 intronic variant | Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ... | Blood Sugar & Diabetes | Moderate | |
| rs5443 | GNB3 C825T | Synonymous exon-10 variant that triggers alternative splicing of the G-protei... | Hormones & Sleep | Strong | |
| rs5082 | APOA2 -265T>C | Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi... | Triglycerides & Fatty Acids | Strong | |
| rs692383 | ABCG1 ABCG1 HDL-c Variant | Intronic variant in the ABCG1 cholesterol efflux transporter gene associated ... | Triglycerides & Fatty Acids | Emerging | |
| rs3765467 | GLP1R Arg131Gln | Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago... | Pharmacogenomics | Moderate | |
| rs587777380 | DYRK1B H90P / H90R | Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the D... | Blood Sugar & Diabetes | Strong | |
| rs6067484 | PTPN1 PTPN1 rs6067484 | Intronic PTPN1 tag SNP raising LDL cholesterol risk in lean individuals | Blood Sugar & Diabetes | Moderate | |
| rs6923761 | GLP1R Gly168Ser | GLP-1 receptor variant that alters response to GLP-1 agonist medications used... | Pharmacogenomics | Moderate |