Tag

Diabetes

19 genetic variants with this tag.

RSID	Gene	Description	Category
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Nutrition & Metabolism	Diabetes Fat Metabolism Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Nutrition & Metabolism	Diabetes Insulin Fat Metabolism	Strong
rs8192678	PPARGC1A Gly482Ser	Master regulator of mitochondrial biogenesis affecting aerobic capacity, endu...	Fitness & Body	Fitness Endurance Diabetes	Strong
rs1799941	SHBG	Promoter region variant affecting sex hormone-binding globulin levels, with t...	Hormones & Sleep	Hormones & Thyroid Cardiovascular Diabetes	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Nutrition & Metabolism	Diabetes Insulin Diet	Established
rs3087243	CTLA4 CT60	Immune checkpoint regulatory variant in the 3'UTR affecting T-cell activation...	Immune & Gut	Immune & Autoimmune Thyroid Diabetes	Strong
rs1205	CRP +1846C>T	3' UTR variant that modulates baseline C-reactive protein levels and inflamma...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Strong
rs1800795	IL6 -174G/C	Promoter variant controlling interleukin-6 expression — affects inflammation,...	Fitness & Body	Inflammation Cardiovascular Fitness	Strong
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Heart & Inflammation	Longevity Aging Cardiovascular	Established
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Nutrition & Metabolism	Zinc Insulin Diabetes	Established
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Nutrition & Metabolism	Fat Metabolism Triglycerides Diet	Established
rs5219	KCNJ11 E23K	Controls the pancreatic beta-cell potassium channel that regulates insulin se...	Nutrition & Metabolism	Diabetes Insulin Metabolic	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Nutrition & Metabolism	Nutrition & Metabolism Insulin Diabetes	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant affecting satiety signaling and metabolic health	Nutrition & Metabolism	Nutrition & Metabolism Obesity Diabetes	Moderate