Tag

Diabetes

46 genetic variants with this tag.

RSID	Gene	Description	Category
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Longevity Aging Cardiovascular	Established
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Nutrition & Metabolism	Diabetes Fat Metabolism Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Nutrition & Metabolism	Diabetes Insulin Fat Metabolism	Strong
rs1799941	SHBG	Promoter region variant affecting sex hormone-binding globulin levels, with t...	Hormones & Sleep	Hormones & Thyroid Cardiovascular Diabetes	Strong
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Nutrition & Metabolism	Diabetes Insulin Diet	Established
rs3087243	CTLA4 CT60	Immune checkpoint regulatory variant in the 3'UTR affecting T-cell activation...	Immune & Gut	Immune & Autoimmune Thyroid Diabetes	Strong
rs1205	CRP +1846C>T	3' UTR variant that modulates baseline C-reactive protein levels and inflamma...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Strong
rs1800795	IL6 -174G/C	Promoter variant controlling interleukin-6 expression — affects inflammation,...	Fitness & Body	Inflammation Cardiovascular Fitness	Strong
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs8192678	PPARGC1A Gly482Ser	Master mitochondrial biogenesis regulator — Ser482 variant reduces PGC-1alpha...	Longevity & Aging	Fitness Endurance Diabetes	Strong
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Heart & Inflammation	Cardiovascular Diabetes Insulin	Moderate
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Longevity Aging Cardiovascular	Strong
rs11590235	SKI	TGF-beta signaling regulator variant identified as the top shared locus betwe...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Moderate
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Nutrition & Metabolism	Zinc Insulin Diabetes	Established
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian Sleep Diabetes	Strong
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs1805097	IRS2 Gly1057Asp	Missense IRS2 variant where Asp/Asp homozygotes are twice as likely to reach ...	Longevity & Aging	Longevity Aging Insulin	Moderate
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Nutrition & Metabolism	Fat Metabolism Triglycerides Diet	Established
rs16847897	TERC	Regulatory variant at the TERC locus associated with shorter telomeres and ac...	Longevity & Aging	Telomere Biology Aging Longevity	Strong
rs11212617	ATM	Intronic variant near the ATM gene affecting metformin's activation of AMPK; ...	Longevity & Aging	Longevity Aging DNA Repair	Moderate
rs5219	KCNJ11 E23K	Controls the pancreatic beta-cell potassium channel that regulates insulin se...	Nutrition & Metabolism	Diabetes Insulin Metabolic	Strong
rs6923761	GLP1R Gly168Ser	GLP-1 receptor variant that alters response to GLP-1 agonist medications used...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs3765467	GLP1R Arg131Gln	Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago...	Pharmacogenomics	Drug Response Diabetes Obesity	Moderate
rs10305492	GLP1R A316T	Rare protective missense variant in the GLP-1 receptor associated with lower ...	Pharmacogenomics	Drug Metabolism Diabetes Insulin	Strong
rs1042044	GLP1R Leu260Phe	GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e...	Pharmacogenomics	Drug Response Pharmacogenomics Obesity	Moderate
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Nutrition & Metabolism	Nutrition & Metabolism Insulin Diabetes	Strong
rs1137101	LEPR Q223R (Gln223Arg)	Common leptin receptor variant affecting satiety signaling and metabolic health	Nutrition & Metabolism	Nutrition & Metabolism Obesity Diabetes	Moderate
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs622342	SLC22A1 A>C	Intronic variant in the OCT1 organic cation transporter reducing hepatic metf...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Diabetes	Moderate
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs1800849	UCP3 -55C>T	Promoter variant in skeletal muscle uncoupling protein 3 that increases UCP3 ...	Nutrition & Metabolism	Fat Metabolism Diabetes Insulin	Moderate
rs696217	GHRL Leu72Met	Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel...	Nutrition & Metabolism	Obesity Appetite Metabolic Syndrome	Moderate
rs10423928	GIPR	Intronic GIPR variant that reduces functional GIP receptor expression via alt...	Nutrition & Metabolism	Diabetes Insulin Diet	Strong
rs1862513	RETN -420C>G	Promoter variant that increases resistin expression via Sp1/Sp3 transcription...	Nutrition & Metabolism	Nutrition & Metabolism Insulin Resistance Inflammation	Moderate
rs10195252	GRB14/COBLL1	Intergenic variant between GRB14 and COBLL1 that acts as an eQTL for GRB14 in...	Nutrition & Metabolism	Fat Metabolism Insulin Lipedema	Strong
rs6548238	TMEM18	Second strongest obesity GWAS locus after FTO - influences hypothalamic appet...	Nutrition & Metabolism	Obesity Appetite Fat Metabolism	Strong
rs1841499	NEGR1	Hypothalamic appetite regulator variant linking obesity susceptibility to mig...	Nutrition & Metabolism	Obesity Appetite Diabetes	Moderate
rs6947337	INHBA	Activin A signaling variant near INHBA linking adipocyte dysfunction to share...	Nutrition & Metabolism	Obesity Fat Metabolism Inflammation	Moderate
rs116862713	PRKAB1	Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig...	Nutrition & Metabolism	Diabetes Insulin Resistance Energy Metabolism	Emerging
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Nutrition & Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Nutrition & Metabolism	Obesity Metabolic Fat Metabolism	Strong
rs7498665	SH2B1 Thr484Ala	Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr...	Nutrition & Metabolism	Obesity Leptin Insulin Resistance	Strong
rs10767664	BDNF	Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e...	Nutrition & Metabolism	Obesity Satiety Appetite	Strong