Tag

Oxidative Stress

46 genetic variants with this tag.

RSID	Gene	Description	Category
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Oxidative Stress	Strong
rs1021737	CTH CTH Ser403Ile	Missense variant in CTH (cystathionine gamma-lyase) that impairs transsulfura...	Blood Pressure & Hypertension	Oxidative Stress	Moderate
rs1050450	GPX1 Pro198Leu	Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the...	Methylation & Detox	Oxidative Stress	Strong
rs1136410	PARP1 Val762Ala	Missense variant in the PARP1 catalytic domain that reduces enzymatic activit...	Longevity & Aging	Oxidative Stress	Strong
rs11555236	SIRT3	Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre...	Longevity & Aging	Oxidative Stress	Moderate
rs12212067	FOXO3	Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac...	Longevity & Aging	Oxidative Stress	Strong
rs13181	ERCC2 Lys751Gln	Missense variant in the XPD helicase that reduces nucleotide excision repair ...	Longevity & Aging	Oxidative Stress	Strong
rs2075674	TFR2 TFR2 Ala617 variant	Synonymous coding variant in transferrin receptor 2 with potential splice-mod...	Iron & Mineral Transport	Oxidative Stress	Emerging
rs1138272	GSTP1 Ala114Val	Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ...	Methylation & Detox	Oxidative Stress	Moderate
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Oxidative Stress	Strong
rs2251780	GSR	Intronic variant in the glutathione reductase gene affecting antioxidant defe...	Vitamins & Nutrient Absorption	Oxidative Stress	Emerging
rs1805007	MC1R R151C	Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...	Skin & Eyes	Oxidative Stress	Established
rs2237583	PON1 PON1 intron variant	Intronic PON1 variant that modulates arylesterase activity of the HDL-bound a...	Vascular Inflammation & Remodeling	Oxidative Stress	Moderate
rs1800625	AGER AGER -429T>C	Promoter variant at position -429 in the AGER gene linked to diabetic complic...	Hormones & Sleep	Oxidative Stress	Moderate
rs11931074	SNCA	SNCA 3′-region variant consistently associated with Parkinson's disease risk ...	Neurology & Cognition	Oxidative Stress	Strong
rs1935949	FOXO3	Second independent FOXO3 longevity signal tagging a distinct intronic haploty...	Longevity & Aging	Oxidative Stress	Moderate
rs2228001	XPC Lys939Gln	Missense variant in the DNA damage recognition gene XPC that reduces global-g...	Fitness & Body	Oxidative Stress	Strong
rs3805435	TNIP1	Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al...	Psoriasis & Spondyloarthropathy	Oxidative Stress	Moderate
rs3877899	SELENOP Ala234Thr	Missense variant in selenoprotein P that alters selenium transport capacity; ...	Vitamins & Nutrient Absorption	Oxidative Stress	Moderate
rs2153960	FOXO3	Intronic FOXO3 tag SNP whose A allele associates with higher circulating IGF-...	Longevity & Aging	Oxidative Stress	Moderate
rs482843	CTH	Intronic CTH variant where GG homozygotes show significantly elevated preecla...	Blood Pressure & Hypertension	Oxidative Stress	Moderate
rs12598836	HMOX2	Intronic variant near heme oxygenase 2 (HMOX2) associated with migraine-with-...	Neurology & Cognition	Oxidative Stress	Moderate
rs1695	GSTP1 Ile105Val	Phase II detoxification enzyme that conjugates glutathione to carcinogens, dr...	Methylation & Detox	Oxidative Stress	Strong
rs2070600	AGER Gly82Ser	Missense variant in the AGER pattern-recognition receptor that reduces solubl...	Hormones & Sleep	Oxidative Stress	Strong
rs705379	PON1 PON1 promoter -108C>T	Promoter polymorphism that controls PON1 gene expression — the T allele (A on...	Vascular Inflammation & Remodeling	Oxidative Stress	Strong
rs854555	PON1 PON1 3'UTR variant	Intronic/downstream PON1 haplotype-tagging variant associated with PON1 activ...	Vascular Inflammation & Remodeling	Oxidative Stress	Emerging
rs1800566	NQO1 Pro187Ser (C609T)	Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it...	Methylation & Detox	Oxidative Stress	Strong
rs547025	SIRT3	Intronic variant in SIRT3 (the principal mitochondrial deacetylase) associate...	Endometriosis & Uterine Health	Oxidative Stress	Moderate
rs887829	UGT1A1 UGT1A1*80	Promoter variant in UGT1A1 that tags the *28 reduced-expression haplotype; T ...	Vascular Inflammation & Remodeling	Oxidative Stress	Strong
rs2031920	CYP2E1 *5B (RsaI)	Promoter variant increasing CYP2E1 inducibility, elevating oxidative stress f...	Pharmacogenomics	Oxidative Stress	Moderate
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Oxidative Stress	Strong
rs2779249	NOS2 Promoter -1026C/A	Functional promoter variant that increases iNOS transcriptional activity up t...	Longevity & Aging	Oxidative Stress	Moderate
rs2802292	FOXO3	Longevity-associated intronic enhancer variant	Longevity & Aging	Oxidative Stress	Established
rs4746	GLO1 Glu111Ala	Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly...	Hormones & Sleep	Oxidative Stress	Moderate
rs3758391	SIRT1	Promoter-region variant in SIRT1 affecting deacetylase expression; T allele e...	Longevity & Aging	Oxidative Stress	Moderate
rs4946935	FOXO3	Functionally validated FOXO3 intronic variant that creates an SRF binding sit...	Longevity & Aging	Oxidative Stress	Strong
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Oxidative Stress	Strong
rs6721961	NFE2L2	Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th...	Longevity & Aging	Oxidative Stress	Moderate
rs5030868	G6PD G6PD Mediterranean	Severe Class II G6PD deficiency variant (c.563C>T, p.Ser188Phe) causing less ...	Blood Sugar & Diabetes	Oxidative Stress	Established
rs2583988	SNCA	SNCA upstream regulatory variant (near gene-5) that is part of the 4-SNP SNCA...	Neurology & Cognition	Oxidative Stress	Emerging
rs4880	SOD2 Val16Ala	Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif...	Methylation & Detox	Oxidative Stress	Strong
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Oxidative Stress	Moderate
rs2736990	SNCA	Intronic SNCA variant (intron 4) associated with Parkinson's disease risk and...	Neurology & Cognition	Oxidative Stress	Strong
rs76723693	G6PD G6PD Nefza (c.968T>C)	Missense variant in glucose-6-phosphate dehydrogenase causing Class III G6PD ...	Blood Sugar & Diabetes	Oxidative Stress	Strong
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Neurology & Cognition	Oxidative Stress	Strong
rs356219	SNCA	SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression...	Neurology & Cognition	Oxidative Stress	Strong