Tag

Oxidative Stress

63 genetic variants with this tag.

RSID	Gene	Description	Category
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Oxidative Stress	Strong
rs1049255	CYBA CYBA 3'UTR A640G	3'UTR variant in the NADPH oxidase p22-phox subunit affecting superoxide gene...	Vascular Inflammation & Remodeling	Oxidative Stress	Moderate
rs11235972	UCP3	Intronic UCP3 variant associated with skeletal muscle fat oxidation capacity,...	Liver Fat	Oxidative Stress	Moderate
rs1021737	CTH CTH Ser403Ile	Missense variant in CTH (cystathionine gamma-lyase) that impairs transsulfura...	Blood Pressure & Hypertension	Oxidative Stress	Moderate
rs1136410	PARP1 Val762Ala	Missense variant in the PARP1 catalytic domain that reduces enzymatic activit...	Longevity & Aging	Oxidative Stress	Strong
rs1050450	GPX1 Pro198Leu	Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the...	Methylation & Detox	Oxidative Stress	Strong
rs11555236	SIRT3	Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre...	Longevity & Aging	Oxidative Stress	Moderate
rs12206094	FOXO3	Functional FOXO3 intronic variant with allele-specific CTCF binding and IGF-1...	Longevity & Aging	Oxidative Stress	Strong
rs12212067	FOXO3	Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac...	Longevity & Aging	Oxidative Stress	Strong
rs12704795	PON2 PON2 intron 1 variant	Intronic PON2 haplotype tag; the A allele is associated with reduced intracel...	Vascular Inflammation & Remodeling	Oxidative Stress	Moderate
rs1154404	ADH5 ADH5 Asthma Risk Haplotype Variant	Intronic variant in ADH5 (GSNOR) in near-complete LD (r²=0.99) with adjacent ...	Allergy & Atopic Disease	Oxidative Stress	Moderate
rs13181	ERCC2 Lys751Gln	Missense variant in the XPD helicase that reduces nucleotide excision repair ...	Longevity & Aging	Oxidative Stress	Strong
rs1805007	MC1R R151C	Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...	Skin & Eyes	Oxidative Stress	Established
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Oxidative Stress	Strong
rs2075674	TFR2 TFR2 Ala617 variant	Synonymous coding variant in transferrin receptor 2 with potential splice-mod...	Iron & Mineral Transport	Oxidative Stress	Emerging
rs2278651	SLC30A1 ZnT1 variant	Intronic variant in SLC30A1 (ZnT1), the primary plasma-membrane zinc efflux t...	Iron & Mineral Transport	Oxidative Stress	Emerging
rs1138272	GSTP1 Ala114Val	Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ...	Methylation & Detox	Oxidative Stress	Moderate
rs11931074	SNCA	SNCA 3′-region variant in the extended 3′ UTR that affects alpha-synuclein mR...	Neurology & Cognition	Oxidative Stress	Strong
rs2251780	GSR	Intronic variant in the glutathione reductase gene affecting antioxidant defe...	Vitamins & Nutrient Absorption	Oxidative Stress	Emerging
rs12598836	HMOX2	Intronic variant near heme oxygenase 2 (HMOX2) associated with migraine-with-...	Neurology & Cognition	Oxidative Stress	Moderate
rs1935949	FOXO3	Second independent FOXO3 longevity signal tagging a distinct intronic haploty...	Longevity & Aging	Oxidative Stress	Moderate
rs482843	CTH	Intronic CTH variant where GG homozygotes show significantly elevated preecla...	Blood Pressure & Hypertension	Oxidative Stress	Moderate
rs1937	TFAM S12T	Missense variant in the TFAM mitochondrial targeting sequence — the C allele ...	Longevity & Aging	Oxidative Stress	Moderate
rs1800624	AGER -374T/A	Promoter variant in the AGER gene that increases RAGE transcription approxima...	Hormones & Sleep	Oxidative Stress	Moderate
rs1800625	AGER AGER -429T>C	Promoter variant at position -429 in the AGER gene that increases RAGE transc...	Hormones & Sleep	Oxidative Stress	Moderate
rs3805435	TNIP1	Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al...	Psoriasis & Spondyloarthropathy	Oxidative Stress	Moderate
rs2153960	FOXO3	Intronic FOXO3 tag SNP whose A allele associates with higher circulating IGF-...	Longevity & Aging	Oxidative Stress	Moderate
rs2237583	PON1 PON1 intron variant	Intronic PON1 variant that modulates arylesterase activity of the HDL-bound a...	Vascular Inflammation & Remodeling	Oxidative Stress	Moderate
rs2253310	FOXO3	Intronic FOXO3 longevity variant; C allele (minor in East Asians) associated ...	Longevity & Aging	Oxidative Stress	Moderate
rs3877899	SELENOP Ala234Thr	Missense variant in selenoprotein P that alters selenium transport capacity; ...	Vitamins & Nutrient Absorption	Oxidative Stress	Moderate
rs547025	SIRT3	Intronic variant in SIRT3 (the principal mitochondrial deacetylase) associate...	Endometriosis & Uterine Health	Oxidative Stress	Moderate
rs1695	GSTP1 Ile105Val	Phase II detoxification enzyme that conjugates glutathione to carcinogens, dr...	Methylation & Detox	Oxidative Stress	Strong
rs17309872	GSS	Downstream regulatory variant of glutathione synthetase (GSS) associated with...	Methylation & Detox	Oxidative Stress	Moderate
rs2228001	XPC Lys939Gln	Missense variant in the DNA damage recognition gene XPC that reduces global-g...	Fitness & Body	Oxidative Stress	Strong
rs2070600	AGER Gly82Ser	Missense variant in the AGER pattern-recognition receptor that reduces solubl...	Hormones & Sleep	Oxidative Stress	Strong
rs6757908	EIF2AK3-AS1	Rare intronic variant in EIF2AK3-AS1, an antisense long non-coding RNA that r...	Endometriosis & Uterine Health	Oxidative Stress	Emerging
rs2031920	CYP2E1 *5B (RsaI)	Promoter variant increasing CYP2E1 inducibility, elevating oxidative stress f...	Pharmacogenomics	Oxidative Stress	Moderate
rs1800566	NQO1 Pro187Ser (C609T)	Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it...	Methylation & Detox	Oxidative Stress	Strong
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Oxidative Stress	Strong
rs2779249	NOS2 Promoter -1026C/A	Functional promoter variant that increases iNOS transcriptional activity up t...	Longevity & Aging	Oxidative Stress	Moderate
rs4729189	PON2	Intronic PON2 variant associated with variation in serum paraoxonase activity...	Vascular Inflammation & Remodeling	Oxidative Stress	Emerging
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Oxidative Stress	Established
rs705379	PON1 PON1 promoter -108C>T	Promoter polymorphism that controls PON1 gene expression — the T allele (A on...	Vascular Inflammation & Remodeling	Oxidative Stress	Strong
rs854555	PON1 PON1 3'UTR variant	Intronic/downstream PON1 haplotype-tagging variant associated with PON1 activ...	Vascular Inflammation & Remodeling	Oxidative Stress	Emerging
rs854571	PON1 PON1 -108C>T promoter variant	Promoter variant that controls PON1 transcription; the T allele reduces PON1 ...	Vascular Inflammation & Remodeling	Oxidative Stress	Strong
rs3758391	SIRT1	Promoter-region variant in SIRT1 affecting deacetylase expression; T allele e...	Longevity & Aging	Oxidative Stress	Moderate
rs854572	PON1 PON1 promoter -909G>C	Promoter polymorphism that modulates PON1 gene expression level — the G allel...	Vascular Inflammation & Remodeling	Oxidative Stress	Moderate
rs887829	UGT1A1 UGT1A1*80	Promoter variant in UGT1A1 that tags the *28 reduced-expression haplotype; T ...	Vascular Inflammation & Remodeling	Oxidative Stress	Strong
rs4946935	FOXO3	Functionally validated FOXO3 intronic variant that creates an SRF binding sit...	Longevity & Aging	Oxidative Stress	Strong
rs659366	UCP2	Promoter variant at position -866 of UCP2 that controls mitochondrial uncoupl...	Longevity & Aging	Oxidative Stress	Moderate
rs2583988	SNCA	SNCA upstream regulatory variant (near gene-5) that is part of the 4-SNP SNCA...	Neurology & Cognition	Oxidative Stress	Emerging
rs6721961	NFE2L2	Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th...	Longevity & Aging	Oxidative Stress	Moderate
rs2736990	SNCA	Intronic SNCA variant (intron 4) associated with Parkinson's disease risk and...	Neurology & Cognition	Oxidative Stress	Strong
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Oxidative Stress	Strong
rs4746	GLO1 Glu111Ala	Missense variant in glyoxalase 1 reducing enzyme activity, allowing methylgly...	Hormones & Sleep	Oxidative Stress	Moderate
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Oxidative Stress	Moderate
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Neurology & Cognition	Oxidative Stress	Strong
rs356219	SNCA	SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression...	Neurology & Cognition	Oxidative Stress	Strong
rs5030868	G6PD G6PD Mediterranean	Severe Class II G6PD deficiency variant (c.563C>T, p.Ser188Phe) causing less ...	Blood Sugar & Diabetes	Oxidative Stress	Established
rs2851301	ADH5 ADH5 Second NF-kB Site Variant	Upstream promoter variant in ADH5 at a potential NF-kB binding site; the mino...	Allergy & Atopic Disease	Oxidative Stress	Emerging
rs28730619	ADH5	Intronic variant in ADH5 (GSNOR) associated with elevated childhood asthma ri...	Allergy & Atopic Disease	Oxidative Stress	Moderate
rs4880	SOD2 Val16Ala	Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif...	Methylation & Detox	Oxidative Stress	Strong
rs76723693	G6PD G6PD Nefza (c.968T>C)	Missense variant in glucose-6-phosphate dehydrogenase causing Class III G6PD ...	Blood Sugar & Diabetes	Oxidative Stress	Strong