Tag

Oxidative Stress

29 genetic variants with this tag.

RSID	Gene	Description	Category
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Longevity & Aging	Longevity Aging Cardiovascular	Established
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Longevity & Aging	Mental Health Neurotransmitters Cardiovascular	Moderate
rs6721961	NFE2L2	Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th...	Longevity & Aging	Oxidative Stress Antioxidants Detoxification	Moderate
rs11555236	SIRT3	Intronic regulatory variant near the SIRT3 VNTR enhancer — the A allele incre...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs659366	UCP2	Promoter variant at position -866 of UCP2 that controls mitochondrial uncoupl...	Longevity & Aging	Longevity Aging Mitochondria	Moderate
rs1805007	MC1R R151C	Strongest "R" allele in the melanocortin-1 receptor, shifting pigment from ph...	Skin & Eyes	Pain Sensitivity Skin Health Anesthesia	Established
rs1136410	PARP1 Val762Ala	Missense variant in the PARP1 catalytic domain that reduces enzymatic activit...	Longevity & Aging	DNA Repair NAD+ Metabolism Longevity	Strong
rs13181	ERCC2 Lys751Gln	Missense variant in the XPD helicase that reduces nucleotide excision repair ...	Longevity & Aging	DNA Repair Longevity Aging	Strong
rs1935949	FOXO3	Second independent FOXO3 longevity signal tagging a distinct intronic haploty...	Longevity & Aging	Longevity Aging Oxidative Stress	Moderate
rs356182	SNCA	Parkinson's disease GWAS risk variant affecting alpha-synuclein expression an...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs2764264	FOXO3	Intronic FOXO3 variant that disrupts an NKX3 transcription factor binding sit...	Longevity & Aging	Longevity Aging Cardiovascular	Strong
rs547025	SIRT3	Intronic variant in SIRT3 (the principal mitochondrial deacetylase) associate...	Fertility & Reproductive Health	Uterine Fibroids Fertility Reproductive Health	Moderate
rs4880	SOD2 Val16Ala	Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif...	Methylation & Detox	Detoxification Oxidative Stress Antioxidants	Strong
rs1050450	GPX1 Pro198Leu	Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the...	Methylation & Detox	Detoxification Oxidative Stress Selenium	Strong
rs1695	GSTP1 Ile105Val	Phase II detoxification enzyme that conjugates glutathione to carcinogens, dr...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs4946935	FOXO3	Functionally validated FOXO3 intronic variant that creates an SRF binding sit...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs1138272	GSTP1 Ala114Val	Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ...	Methylation & Detox	Detoxification Glutathione Phase II	Moderate
rs12206094	FOXO3	Functional FOXO3 intronic variant with allele-specific CTCF binding and IGF-1...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs1800566	NQO1 Pro187Ser (C609T)	Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it...	Methylation & Detox	Detoxification Phase II Oxidative Stress	Strong
rs2228001	XPC Lys939Gln	Missense variant in the DNA damage recognition gene XPC that reduces global-g...	Fitness & Body	DNA Repair Fitness Recovery	Strong
rs13217795	FOXO3	Original 2008 Willcox longevity discovery variant; C allele tags the protecti...	Longevity & Aging	Longevity Aging Oxidative Stress	Strong
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Detoxification Antioxidants Oxidative Stress	Strong
rs2253310	FOXO3	Intronic FOXO3 longevity variant; C allele (minor in East Asians) associated ...	Longevity & Aging	Longevity Aging Oxidative Stress	Moderate
rs12212067	FOXO3	Intronic FOXO3 variant whose minor G allele creates an MZF1 transcription fac...	Longevity & Aging	Longevity Aging Inflammation	Strong
rs356219	SNCA	SNCA 3′-region regulatory variant that upregulates alpha-synuclein expression...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs1937	TFAM S12T	Missense variant in the TFAM mitochondrial targeting sequence — the C allele ...	Longevity & Aging	Mitochondria Longevity Aging	Moderate
rs2736990	SNCA	Intronic SNCA variant (intron 4) associated with Parkinson's disease risk and...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong
rs11931074	SNCA	SNCA 3′-region variant in the extended 3′ UTR that affects alpha-synuclein mR...	Brain & Mental Health	Neurological Risk Parkinson's Neuroprotection	Strong