Tag

Cancer Risk

10 genetic variants with this tag.

RSID	Gene	Description	Category
rs12913832	HERC2	Intronic enhancer variant controlling OCA2 expression and determining blue ve...	Skin & Eyes	Skin, Hair & Pigmentation Eye Color Melanoma	Established
rs12203592	IRF4 T allele	Regulatory variant in IRF4 enhancer affecting melanocyte pigmentation, sun se...	Skin & Eyes	Skin, Hair & Pigmentation Sun Sensitivity Melanoma	Strong
rs1042602	TYR S192Y	Common tyrosinase variant affecting melanin production, skin pigmentation, ta...	Skin & Eyes	Skin Pigmentation Melanoma Sun Sensitivity	Strong
rs1800947	CRP +1059G>C	Synonymous exon 2 variant that influences baseline C-reactive protein express...	Heart & Inflammation	Inflammation Cardiovascular Cancer Risk	Strong
rs2736100	TERT	Common intron 2 variant in the telomerase gene that influences telomere lengt...	Immune & Gut	Mental Health Telomere Biology Aging	Strong
rs2740574	CYP3A4 *1B -392A>G	Promoter variant affecting CYP3A4 expression, most common in African populations	Pharmacogenomics	Drug Metabolism Pharmacogenomics Cancer Risk	Moderate
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Nutrition & Metabolism	Fat Metabolism Triglycerides Diet	Established
rs1056836	CYP1B1 Leu432Val	Phase I detoxification enzyme that hydroxylates estradiol to potentially geno...	Methylation & Detox	Detoxification Phase I Estrogen Metabolism	Moderate
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Detoxification Antioxidants Oxidative Stress	Strong
rs71748309	GSTT1 Null (Gene Deletion)	Complete deletion of the GSTT1 gene eliminating glutathione conjugation capac...	Methylation & Detox	Detoxification Glutathione Phase II	Strong