|
rs4986790
|
TLR4
Asp299Gly
|
Missense variant in Toll-like receptor 4 reducing bacterial endotoxin recogni...
|
Immune & Gut
|
|
Strong
|
|
rs1800896
|
IL10
-1082 A>G
|
Promoter variant affecting IL-10 production — the master anti-inflammatory cy...
|
Immune & Gut
|
|
Strong
|
|
rs1800629
|
TNF
-308 G>A
|
Promoter variant increasing TNF-alpha production 2-3 fold, associated with au...
|
Immune & Gut
|
|
Strong
|
|
rs3087243
|
CTLA4
CT60
|
Immune checkpoint regulatory variant in the 3'UTR affecting T-cell activation...
|
Immune & Gut
|
|
Strong
|
|
rs1061170
|
CFH
Y402H
|
Strongly increases risk of age-related macular degeneration through impaired ...
|
Skin & Eyes
|
|
Established
|
|
rs1205
|
CRP
+1846C>T
|
3' UTR variant that modulates baseline C-reactive protein levels and inflamma...
|
Heart & Inflammation
|
|
Strong
|
|
rs1800795
|
IL6
-174G/C
|
Promoter variant controlling interleukin-6 expression — affects inflammation,...
|
Fitness & Body
|
|
Strong
|
|
rs2004640
|
IRF5
G198T
|
Intronic variant creating alternative splice site that increases type I inter...
|
Immune & Gut
|
|
Strong
|
|
rs16944
|
IL1B
-511C>T
|
Promoter variant affecting IL-1 beta production, influencing inflammatory res...
|
Heart & Inflammation
|
|
Strong
|
|
rs2230199
|
C3
R102G
|
Missense variant in complement C3 increasing risk of age-related macular dege...
|
Skin & Eyes
|
|
Established
|
|
rs2802292
|
FOXO3
|
Longevity-associated intronic enhancer variant with 1.9-fold increased probab...
|
Heart & Inflammation
|
|
Established
|
|
rs11209026
|
IL23R
R381Q
|
Strongly protective variant against inflammatory bowel disease and other auto...
|
Immune & Gut
|
|
Established
|
|
rs1801181
|
CBS
A360A
|
A synonymous variant in CBS affecting homocysteine metabolism and associated ...
|
Methylation & Detox
|
|
Moderate
|
|
rs13107325
|
SLC39A8
A391T
|
Zinc and manganese transporter variant that reduces metal ion absorption, aff...
|
Immune & Gut
|
|
Strong
|
|
rs1979277
|
SHMT1
C1420T
|
Alters one-carbon metabolism and folate distribution; influences cancer risk,...
|
Methylation & Detox
|
|
Moderate
|
|
rs5128
|
APOC3
3238C>G (SstI)
|
Regulates triglyceride metabolism through effects on APOC3 expression in the ...
|
Heart & Inflammation
|
|
Strong
|
|
rs1800947
|
CRP
+1059G>C
|
Synonymous exon 2 variant that influences baseline C-reactive protein express...
|
Heart & Inflammation
|
|
Strong
|
|
rs2104772
|
TNC
|
Affects tenascin C protein levels and elasticity, influencing tendon injury r...
|
Fitness & Body
|
|
Strong
|
|
rs819147
|
AHCY
|
Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...
|
Methylation & Detox
|
|
Moderate
|
|
rs4073
|
IL8
-251A>T
|
Promoter variant affecting interleukin-8 transcription and inflammatory burden
|
Heart & Inflammation
|
|
Strong
|
|
rs11136000
|
CLU
|
Intronic variant in clusterin gene affecting Alzheimer's disease risk through...
|
Brain & Mental Health
|
|
Established
|
|
rs1800872
|
IL10
-592 C>A
|
Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...
|
Heart & Inflammation
|
|
Strong
|
|
rs143383
|
GDF5
C/T
|
Regulatory variant in GDF5 affecting cartilage development and osteoarthritis...
|
Fitness & Body
|
|
Established
|
|
rs3025058
|
MMP3
5A/6A
|
Promoter polymorphism affecting MMP3 enzyme expression levels, influencing ca...
|
Fitness & Body
|
|
Strong
|
|
rs3751143
|
P2RX7
Glu496Ala
|
Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...
|
Brain & Mental Health
|
|
Strong
|
|
rs28929474
|
SERPINA1
Z allele (E342K)
|
Most common alpha-1 antitrypsin deficiency variant causing protein misfolding...
|
Nutrition & Metabolism
|
|
Established
|
|
rs17300539
|
ADIPOQ
-11391G>A
|
Promoter variant affecting adiponectin secretion and metabolic syndrome risk
|
Nutrition & Metabolism
|
|
Strong
|
|
rs1001179
|
CAT
-262C>T
|
Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...
|
Methylation & Detox
|
|
Strong
|