Tag

Diet

106 genetic variants with this tag.

RSID	Gene	Description	Category
rs2274327	CA6 Thr55Met	Reduces salivary carbonic anhydrase VI (gustin) secretion, impairing oral aci...	Dental & Oral Health	Dental & Oral Health Zinc Microbiome	Moderate
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Nutrition & Metabolism	Diabetes Fat Metabolism Diet	Established
rs10455872	LPA	Intronic variant strongly associated with elevated lipoprotein(a) levels and ...	Heart & Inflammation	Cardiovascular Cholesterol Blood Thinners	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Nutrition & Metabolism	Diabetes Insulin Fat Metabolism	Strong
rs11591147	PCSK9 R46L	Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and ...	Heart & Inflammation	Cardiovascular Cholesterol Diet	Established
rs1801282	PPARG Pro12Ala	Insulin sensitivity - affects how well your cells respond to insulin	Nutrition & Metabolism	Diabetes Insulin Diet	Established
rs12696304	TERC	Regulatory variant near the telomerase RNA gene associated with shorter telom...	Longevity & Aging	Mental Health Cardiovascular Diet	Established
rs2236225	MTHFD1 G1958A	Folate processing enzyme — reduced stability increases choline need	Methylation & Detox	Methylation Folate B Vitamins	Strong
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Nutrition & Metabolism	Cholesterol Cardiovascular Alzheimer's	Established
rs708272	CETP TaqIB	Influences HDL cholesterol levels and particle size through effects on choles...	Heart & Inflammation	Cardiovascular Cholesterol Longevity	Strong
rs1799750	MMP1 1G/2G	Promoter polymorphism affecting MMP1 expression and collagen degradation rate...	Skin & Eyes	Skin, Hair & Pigmentation Cardiovascular Diet	Strong
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; T allele c...	Heart & Inflammation	Cardiovascular Cholesterol Triglycerides	Strong
rs699	AGT M235T	Angiotensinogen level variant affecting blood pressure, sodium sensitivity, a...	Fitness & Body	Cardiovascular Diet Fitness	Strong
rs174547	FADS1	Omega-3 fatty acid conversion efficiency - affects ability to make EPA/DHA fr...	Nutrition & Metabolism	Omega-3 Fat Metabolism Diet	Strong
rs1544410	VDR BsmI	Vitamin D receptor — affects how well vitamin D activates cellular processes	Methylation & Detox	B Vitamins Methylation Diet	Moderate
rs3135506	APOA5 S19W	Triglyceride metabolism - affects fasting triglyceride levels and cardiovascu...	Nutrition & Metabolism	Triglycerides Cardiovascular Fat Metabolism	Strong
rs662	PON1 Q192R	Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...	Heart & Inflammation	Cardiovascular Detoxification Cholesterol	Moderate
rs762551	CYP1A2 *1F	Caffeine metabolism - affects how quickly you process caffeine	Pharmacogenomics	Drug Metabolism Diet Cardiovascular	Strong
rs10490924	ARMS2 A69S	Second strongest genetic risk factor for age-related macular degeneration, af...	Skin & Eyes	Eye Health Aging Antioxidants	Established
rs10741657	CYP2R1 promoter variant	Vitamin D activation — converts D3 to 25(OH)D in the liver	Methylation & Detox	B Vitamins Methylation Diet	Strong
rs1799883	FABP2 Ala54Thr	Intestinal fat absorption - affects how efficiently you absorb dietary fat	Nutrition & Metabolism	Fat Metabolism Diet Insulin	Moderate
rs1801260	CLOCK 3111T>C (3'UTR)	Core circadian clock transcription factor variant affecting mRNA stability, a...	Hormones & Sleep	Sleep Circadian Chronotype	Moderate
rs2229765	IGF1R c.3179G>A (E1013E)	Synonymous IGF1R variant associated with lower circulating IGF-1 levels and e...	Longevity & Aging	Longevity Insulin Growth Factors	Moderate
rs7501331	BCO1 Ala379Val	Reduces beta-carotene conversion to vitamin A (retinol) by ~32% per T allele,...	Nutrition & Metabolism	Vitamin A Beta-Carotene Diet	Strong
rs7946	PEMT Val175Met	Phosphatidylcholine production — affects dietary choline requirements	Methylation & Detox	Methylation Folate B Vitamins	Strong
rs12934922	BCO1 Arg267Ser	Reduces beta-carotene to retinol (vitamin A) conversion efficiency, contribut...	Nutrition & Metabolism	Vitamins Vitamin A Diet	Strong
rs6511720	LDLR Intron 1	Common regulatory variant in the LDL receptor gene affecting LDLR expression,...	Heart & Inflammation	Cardiovascular Cholesterol Statins	Strong
rs10830963	MTNR1B Intron C>G	Melatonin receptor variant that extends nighttime melatonin signaling in panc...	Hormones & Sleep	Sleep Melatonin Circadian	Established
rs12740374	SORT1 1p13.3 locus	Regulatory variant that increases sortilin expression, lowering LDL cholester...	Heart & Inflammation	Cholesterol Cardiovascular Lipid Metabolism	Established
rs2241880	ATG16L1 T300A	Autophagy gene variant affecting bacterial clearance in gut epithelial cells,...	Immune & Gut	Autophagy Diet Immune Function	Established
rs4588	GC Thr436Lys	Alters vitamin D binding protein affinity, affecting total and bioavailable 2...	Nutrition & Metabolism	Vitamin D Bone Health Cardiovascular	Strong
rs671	ALDH2 *2	Alcohol metabolism - flush reaction and cancer risk	Pharmacogenomics	Drug Metabolism Diet Detoxification	Established
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Heart & Inflammation	Triglycerides Cardiovascular Cholesterol	Strong
rs7041	GC Asp432Glu	Vitamin D binding protein variant that determines VDBP isoform, affecting vit...	Nutrition & Metabolism	Vitamin D Bone Health Diet	Strong
rs13107325	SLC39A8 A391T	Zinc and manganese transporter variant that reduces metal ion absorption, aff...	Immune & Gut	Cardiovascular Inflammation Diet	Strong
rs567754	BHMT BHMT-02	Intronic variant in betaine-homocysteine methyltransferase gene associated wi...	Methylation & Detox	Methylation Homocysteine B Vitamins	Moderate
rs1979277	SHMT1 C1420T	Alters one-carbon metabolism and folate distribution; influences cancer risk,...	Methylation & Detox	Methylation Folate B Vitamins	Moderate
rs2228570	VDR FokI C>T	Vitamin D receptor start codon variant — determines receptor protein length a...	Nutrition & Metabolism	Vitamin D Bone Health Diet	Strong
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs33972313	SLC23A1 Val264Met	Primary intestinal and renal vitamin C transporter — variant reduces ascorbat...	Nutrition & Metabolism	Vitamins Vitamin C Diet	Strong
rs662799	APOA5 -1131T>C	Promoter variant that reduces APOA5 expression, impairing lipoprotein lipase ...	Heart & Inflammation	Triglycerides Fat Metabolism Cardiovascular	Strong
rs6994076	TTPA -980T>A	Regulates expression of the alpha-tocopherol transfer protein, the key determ...	Nutrition & Metabolism	Vitamins Vitamin E Diet	Strong
rs1333049	CDKN2B-AS1 9p21 locus	Strongest GWAS signal for coronary artery disease; risk C allele accelerates ...	Longevity & Aging	Cardiovascular Diet Lifestyle	Established
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Heart & Inflammation	Cardiovascular Diabetes Insulin	Moderate
rs855791	TMPRSS6 Ala736Val	Master regulator of iron absorption via hepcidin control — the strongest comm...	Nutrition & Metabolism	Iron Cardiovascular Diet	Established
rs1800562	HFE C282Y	Primary variant causing hereditary hemochromatosis type 1, disrupting iron re...	Nutrition & Metabolism	Iron Hemochromatosis Vitamins	Established
rs1799945	HFE H63D	Second most common hereditary hemochromatosis variant, mildly increasing iron...	Nutrition & Metabolism	Iron Hemochromatosis Cardiovascular	Established
rs2241766	ADIPOQ T45G	Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability...	Heart & Inflammation	Fat Metabolism Obesity Insulin	Moderate
rs3801387	WNT16	Intronic variant affecting cortical bone thickness, bone mineral density, and...	Fitness & Body	Bone & Joint Cardiovascular Diet	Established
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Nutrition & Metabolism	Zinc Insulin Diabetes	Established
rs35333999	PER2 V903I	Missense variant in core circadian clock gene PER2 that lengthens intrinsic c...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Brain & Mental Health	Pain Sensitivity Neurotransmitters Cardiovascular	Strong
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Circadian Sleep Diabetes	Strong
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs4977574	CDKN2B-AS1 9p21.3	Independent 9p21.3 CAD risk signal in ANRIL; G allele elevates coronary arter...	Heart & Inflammation	Cardiovascular Atherosclerosis Diet	Established
rs738409	PNPLA3 I148M	Strongest genetic risk factor for non-alcoholic fatty liver disease, progress...	Nutrition & Metabolism	Fat Metabolism Triglycerides Diet	Established
rs4988235	LCT -13910C>T	Lactase persistence - ability to digest lactose (milk sugar) in adulthood	Methylation & Detox	Lactose Food Sensitivity Diet	Established
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Nutrition & Metabolism	Metabolic Cardiovascular Cholesterol	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Nutrition & Metabolism	Nutrition & Metabolism Insulin Diabetes	Strong
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Detoxification Glutathione Phase II	Strong
rs4994	ADRB3 Trp64Arg	Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs1048943	CYP1A1 Ile462Val (*2C)	Phase I detoxification enzyme that activates polycyclic aromatic hydrocarbons...	Methylation & Detox	Detoxification Phase I Xenobiotics	Strong
rs1800592	UCP1 A-3826G	Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs660339	UCP2 Ala55Val	Missense variant reducing mitochondrial uncoupling efficiency in white adipos...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs1800849	UCP3 -55C>T	Promoter variant in skeletal muscle uncoupling protein 3 that increases UCP3 ...	Nutrition & Metabolism	Fat Metabolism Diabetes Insulin	Moderate
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Strong
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Nutrition & Metabolism	Leptin Satiety Obesity	Moderate
rs1042571	POMC	3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi...	Nutrition & Metabolism	Obesity Appetite Diet	Moderate
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Nutrition & Metabolism	Fat Metabolism Obesity Insulin	Moderate
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs7566605	INSIG2	Upstream regulatory variant near INSIG2 that influences lipogenesis control a...	Nutrition & Metabolism	Obesity Fat Metabolism Diet	Moderate
rs10423928	GIPR	Intronic GIPR variant that reduces functional GIP receptor expression via alt...	Nutrition & Metabolism	Diabetes Insulin Diet	Strong
rs2605100	LYPLAL1	Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio...	Nutrition & Metabolism	Obesity Appetite Diet	Strong
rs987237	TFAP2B	Adipocyte transcription factor variant influencing central fat distribution a...	Nutrition & Metabolism	Fat Metabolism Diet Obesity	Moderate
rs2241423	MAP2K5	MAPK signaling variant in MAP2K5 associated with BMI through altered adipogen...	Nutrition & Metabolism	Fat Metabolism Obesity Diet	Moderate
rs4654748	NBPF3	Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...	Nutrition & Metabolism	B Vitamins Homocysteine Neurotransmitters	Strong
rs1256335	ALPL	Intronic variant near ALPL associated with increased alkaline phosphatase act...	Nutrition & Metabolism	B Vitamins Methylation Cardiovascular	Strong
rs61735836	FTCD	Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...	Nutrition & Metabolism	Methylation Folate B Vitamins	Strong
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Nutrition & Metabolism	HDL Cholesterol Fat Metabolism Cholesterol	Strong
rs174537	FADS1	Regulatory variant in the FADS1 locus that controls delta-5 desaturase expres...	Nutrition & Metabolism	Omega-3 Fat Metabolism Cardiovascular	Strong
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Nutrition & Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-...	Nutrition & Metabolism	Obesity Metabolic Fat Metabolism	Strong
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Nutrition & Metabolism	Liver Health Fat Metabolism Cholesterol	Established
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Nutrition & Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs2954021	TRIB1	Near-gene variant influencing hepatic lipid metabolism; G allele raises trigl...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Established
rs7834555	BCO1	Intergenic GWAS tag SNP near the BCO1 pathway, associated with circulating be...	Nutrition & Metabolism	Vitamin A Beta-Carotene Diet	Emerging
rs3733591	SLC2A9 Arg265His	Missense variant in the major renal urate transporter; the Arg265 (C) allele ...	Nutrition & Metabolism	Gout Cardiovascular Diet	Strong
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Nutrition & Metabolism	Liver Health Fat Metabolism Triglycerides	Strong
rs2282679	GC	Intronic GWAS tag variant in the vitamin D binding protein gene, the stronges...	Nutrition & Metabolism	Vitamin D Bone Health Cardiovascular	Established
rs505802	SLC22A12	Upstream regulatory variant in the URAT1 urate reabsorption transporter gene;...	Nutrition & Metabolism	Gout Uric Acid Cardiovascular	Established
rs2078267	SLC22A11	Intronic variant in the OAT4 renal urate transporter that modulates uric acid...	Nutrition & Metabolism	Uric Acid Gout Diet	Strong
rs6013897	CYP24A1	Near-gene regulatory variant affecting vitamin D 24-hydroxylase expression — ...	Nutrition & Metabolism	Vitamin D Bone Health Diet	Strong
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Nutrition & Metabolism	Triglycerides Fat Metabolism Insulin	Strong
rs6564851	BCO1	Upstream regulatory variant that reduces BCO1 (BCMO1) catalytic activity by ~...	Nutrition & Metabolism	Vitamin A Beta-Carotene Diet	Strong
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Nutrition & Metabolism	Triglycerides Cardiovascular Cholesterol	Strong
rs3760775	FUT6	Near-gene regulatory variant near FUT6 that reduces fucosyltransferase expres...	Nutrition & Metabolism	B Vitamins Folate Homocysteine	Moderate
rs6053005	SLC23A2	Intronic variant in the SVCT2 tissue vitamin C transporter — associated with ...	Nutrition & Metabolism	Vitamin C Vitamins Micronutrients	Moderate
rs6133175	SLC23A2	Intronic variant in the tissue vitamin C transporter SVCT2 — GG homozygotes c...	Nutrition & Metabolism	Vitamin C Vitamins Diet	Moderate
rs11942223	SLC2A9	Intronic SLC2A9 variant tagging an independent urate-transport signal; the pr...	Nutrition & Metabolism	Gout Uric Acid Cardiovascular	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Nutrition & Metabolism	Fat Metabolism Liver Health Triglycerides	Strong
rs6420424	BCO1	Upstream regulatory variant near BCO1 that reduces beta-carotene to vitamin A...	Nutrition & Metabolism	Vitamin A Beta-Carotene Diet	Moderate
rs16890979	SLC2A9	Missense variant in the GLUT9 renal urate transporter; the T allele (Val→Ile ...	Nutrition & Metabolism	Gout Uric Acid Diet	Moderate