Tag

Diet

116 genetic variants with this tag.

RSID	Gene	Description	Category
rs1044250	ANGPTL4 T266M	Protective missense variant that reduces LPL inhibition, lowering fasting tri...	Triglycerides & Fatty Acids	Diet	Moderate
rs10455872	LPA	Intronic variant strongly associated with elevated lipoprotein(a) levels and ...	Atherogenic Lipoproteins	Diet	Established
rs10490924	ARMS2 A69S	Second strongest genetic risk factor for age-related macular degeneration, af...	Skin & Eyes	Diet	Established
rs1155563	GC	Intronic tag SNP in the vitamin D binding protein gene, influencing circulati...	Vitamin D Metabolism	Diet	Strong
rs11591147	PCSK9 R46L	Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and ...	Atherogenic Lipoproteins	Diet	Established
rs116843064	ANGPTL4 ANGPTL4 E40K	Missense variant that reduces ANGPTL4's inhibition of lipoprotein lipase, low...	Triglycerides & Fatty Acids	Diet	Strong
rs12593008	LIPC	Intronic LIPC variant in intron 1 associated with low HDL risk, predominantly...	Triglycerides & Fatty Acids	Diet	Moderate
rs1260326	GCKR P446L	Coding GCKR variant (Pro446Leu) that directly reduces GCKRP sensitivity to fr...	Liver Fat	Diet	Strong
rs1048943	CYP1A1 Ile462Val (*2C)	Phase I detoxification enzyme that activates polycyclic aromatic hydrocarbons...	Methylation & Detox	Diet	Strong
rs10938397	GNPDA2	GIANT consortium GWAS obesity locus near GNPDA2	Appetite & Obesity	Diet	Strong
rs12510549	SLC2A9	Intergenic variant in the SLC2A9 urate-transporter locus — the C allele is as...	Uric Acid & Kidney Function	Diet	Strong
rs16930609	CYP2R1	Upstream regulatory variant in CYP2R1 that tags a haplotype associated with r...	Vitamin D Metabolism	Diet	Moderate
rs1256335	ALPL	Intronic variant near ALPL associated with increased alkaline phosphatase act...	Vitamins & Nutrient Absorption	Diet	Strong
rs1993116	CYP2R1 CYP2R1 rs1993116	Intronic regulatory variant in CYP2R1 that reduces hepatic vitamin D 25-hydro...	Vitamin D Metabolism	Diet	Moderate
rs1175544	PPARG PPARG rs1175544	Intronic PPARG variant that accounts for ~7% of individual variation in body ...	Fat Storage & Energy	Diet	Emerging
rs121918389	APOB Q1477X (apoB-32)	Nonsense mutation producing a severely truncated apolipoprotein B (apoB-32) t...	Cholesterol & Lipoproteins	Diet	Strong
rs12740374	SORT1 1p13.3 locus	Regulatory variant that increases sortilin expression, lowering LDL cholester...	Coronary Artery Disease & Atherosclerosis	Diet	Established
rs2274327	CA6 Thr55Met	Reduces salivary carbonic anhydrase VI (gustin) secretion, impairing oral aci...	Dental & Oral Health	Diet	Moderate
rs2642438	MTARC1 p.Ala165Thr (A165T)	Protective missense variant that reduces MTARC1 protein stability, cutting he...	Liver Fat	Diet	Established
rs1532085	LIPC	Intronic eQTL that reduces hepatic lipase expression, raising HDL-C levels wh...	Triglycerides & Fatty Acids	Diet	Strong
rs16890979	SLC2A9	Missense variant in the GLUT9 renal urate transporter; the T allele (Val→Ile ...	Uric Acid & Kidney Function	Diet	Moderate
rs1800562	HFE C282Y	Primary variant causing hereditary hemochromatosis type 1, disrupting iron re...	Iron & Mineral Transport	Diet	Established
rs2228570	VDR FokI C>T	Vitamin D receptor start codon variant — determines receptor protein length a...	Vitamin D Metabolism	Diet	Strong
rs11605924	CRY2 Intron Variant	Circadian clock gene variant affecting fasting glucose, hepatic lipid metabol...	Hormones & Sleep	Diet	Strong
rs1535	FADS2	Intronic FADS2 variant with stronger independent associations than rs174575 f...	Triglycerides & Fatty Acids	Diet	Strong
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Appetite & Obesity	Diet	Strong
rs2078267	SLC22A11	Intronic variant in the OAT4 renal urate transporter that modulates uric acid...	Uric Acid & Kidney Function	Diet	Strong
rs4240624	PPP1R3B Near-gene variant	Intronic PPP1R3B variant that increases hepatic glycogen accumulation, elevat...	Liver Fat	Diet	Strong
rs17321515	TRIB1	Near-gene variant 30–44 kb downstream of TRIB1; A allele raises triglycerides...	Triglycerides & Fatty Acids	Diet	Strong
rs4841132	PPP1R3B	Near-gene PPP1R3B variant used as primary tagging SNP in the Stender 2018 stu...	Liver Fat	Diet	Strong
rs1501299	ADIPOQ +276G>T	Intronic variant in the adiponectin gene that influences circulating adiponec...	Coronary Artery Disease & Atherosclerosis	Diet	Moderate
rs174535	MYRF	Missense variant in the MYRF/FADS gene cluster region on chromosome 11 associ...	Triglycerides & Fatty Acids	Diet	Moderate
rs2282679	GC	Intronic GWAS tag variant in the vitamin D binding protein gene, the stronges...	Vitamin D Metabolism	Diet	Established
rs13107325	SLC39A8 A391T	Zinc and manganese transporter variant that reduces metal ion absorption, aff...	IBD & Mucosal Immunity	Diet	Strong
rs174537	FADS1	Regulatory variant in the FADS1 locus that controls delta-5 desaturase expres...	Triglycerides & Fatty Acids	Diet	Strong
rs2815752	NEGR1	Top obesity GWAS variant near NEGR1	Appetite & Obesity	Diet	Strong
rs475688	SLC22A12	Intronic regulatory variant in the URAT1 renal urate transporter gene; the T ...	Uric Acid & Kidney Function	Diet	Strong
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Liver Fat	Diet	Strong
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Fat Storage & Energy	Diet	Strong
rs174541	FADS1 FADS1 C>G (delta-5 desaturase depth)	Intronic regulatory variant in FADS1 that reduces delta-5 desaturase expressi...	Triglycerides & Fatty Acids	Diet	Strong
rs2413450	TMPRSS6 TMPRSS6 iron regulation variant	Intronic TMPRSS6 variant associated with lower MCV, MCH, and hemoglobin level...	Iron & Mineral Transport	Diet	Strong
rs4588	GC Thr436Lys	Alters vitamin D binding protein affinity, affecting total and bioavailable 2...	Vitamin D Metabolism	Diet	Strong
rs505802	SLC22A12	Upstream regulatory variant in the URAT1 urate reabsorption transporter gene;...	Uric Acid & Kidney Function	Diet	Established
rs641738	MBOAT7	Regulatory variant that reduces MBOAT7 expression in the liver, impairing pho...	Liver Fat	Diet	Strong
rs174546	FADS1	3'UTR regulatory variant in FADS1 that disrupts a miR-149-5p binding site, re...	Triglycerides & Fatty Acids	Diet	Strong
rs1800592	UCP1 A-3826G	Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ...	Fat Storage & Energy	Diet	Moderate
rs174547	FADS1	Omega-3 fatty acid conversion efficiency - affects ability to make EPA/DHA fr...	Triglycerides & Fatty Acids	Diet	Strong
rs28942083	LDLR Cys667Tyr	Pathogenic LDLR missense variant abolishing LDL receptor surface expression, ...	Cholesterol & Lipoproteins	Diet	Established
rs33972313	SLC23A1 Val264Met	Primary intestinal and renal vitamin C transporter — variant reduces ascorbat...	Vitamins & Nutrient Absorption	Diet	Strong
rs3827103	MC3R	Common MC3R missense variant that reduces receptor expression and shifts nutr...	Appetite & Obesity	Diet	Moderate
rs6837293	PRKG2	Intronic variant in PRKG2 (cGMP-dependent protein kinase II); the T allele wa...	Uric Acid & Kidney Function	Diet	Emerging
rs7041	GC Asp432Glu	Vitamin D binding protein variant that determines VDBP isoform, affecting vit...	Vitamin D Metabolism	Diet	Strong
rs12243326	TCF7L2 TCF7L2 Incretin Response Depth Variant	Intronic TCF7L2 depth variant replicated across multiple populations as a sec...	Blood Sugar & Diabetes	Diet	Moderate
rs1801260	CLOCK 3111T>C (3'UTR)	Core circadian clock transcription factor variant affecting mRNA stability, a...	Hormones & Sleep	Diet	Moderate
rs2304795	PLIN1	Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit...	Fat Storage & Energy	Diet	Moderate
rs855791	TMPRSS6 Ala736Val	Master regulator of iron absorption via hepcidin control — the strongest comm...	Iron & Mineral Transport	Diet	Established
rs12255372	TCF7L2	Second TCF7L2 diabetes variant - compounds risk with rs7903146	Blood Sugar & Diabetes	Diet	Strong
rs174561	FADS1	Intronic variant in the FADS1 gene cluster that tags a haplotype block contro...	Triglycerides & Fatty Acids	Diet	Strong
rs3760775	FUT6	Near-gene regulatory variant near FUT6 that lowers circulating vitamin B12	Vitamins & Nutrient Absorption	Diet	Moderate
rs780094	GCKR	Intronic GCKR variant in strong LD with the coding P446L substitution (rs1260...	Liver Fat	Diet	Strong
rs174568	FADS2 FADS2 C>T (delta-6 desaturase)	Intronic regulatory variant in FADS2 encoding delta-6 desaturase, the rate-li...	Triglycerides & Fatty Acids	Diet	Moderate
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Cholesterol & Lipoproteins	Diet	Established
rs6511720	LDLR Intron 1	Common regulatory variant in the LDL receptor gene affecting LDLR expression,...	Atherogenic Lipoproteins	Diet	Strong
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Blood Sugar & Diabetes	Diet	Established
rs1544410	VDR BsmI	Vitamin D receptor — affects how well vitamin D activates cellular processes	Methylation & Detox	Diet	Moderate
rs174572	FADS2	Intronic variant in FADS2 that reduces delta-6 desaturase activity, impairing...	Triglycerides & Fatty Acids	Diet	Strong
rs2241880	ATG16L1 T300A	Autophagy gene variant affecting bacterial clearance in gut epithelial cells,...	IBD & Mucosal Immunity	Diet	Established
rs2959272	PPARG PPARG intronic calorie-restriction trial variant	Intronic PPARG variant significantly associated with individual variation in ...	Fat Storage & Energy	Diet	Emerging
rs571312	MC4R MC4R Regulatory Variant (Appetite Signaling)	Regulatory variant upstream of MC4R associated with increased caloric intake,...	Appetite & Obesity	Diet	Strong
rs662799	APOA5 -1131T>C	Promoter variant that reduces APOA5 expression, impairing lipoprotein lipase ...	Atherogenic Lipoproteins	Diet	Strong
rs174616	FADS2 FADS2 Haplotype Block Variant	Intronic FADS2 variant; A allele carriers have reduced delta-6 desaturase act...	Triglycerides & Fatty Acids	Diet	Strong
rs370793608	ALDOB ALDOB Y204X	Nonsense variant in the aldolase B gene creating a premature stop codon at po...	Metabolic Enzymes & Rare Disorders	Diet	Established
rs662	PON1 Q192R	Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...	Vascular Inflammation & Remodeling	Diet	Moderate
rs2229765	IGF1R c.3179G>A (E1013E)	Synonymous IGF1R variant associated with lower circulating IGF-1 levels and e...	Longevity & Aging	Diet	Moderate
rs520354	APOB APOB IVS6+360	Intronic APOB variant where the A allele (plus strand) is associated with app...	Cholesterol & Lipoproteins	Diet	Moderate
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; A allele c...	Atherogenic Lipoproteins	Diet	Strong
rs1799883	FABP2 Ala54Thr	Intestinal fat absorption - affects how efficiently you absorb dietary fat	Triglycerides & Fatty Acids	Diet	Moderate
rs708272	CETP TaqIB	Influences HDL cholesterol levels and particle size through effects on choles...	Atherogenic Lipoproteins	Diet	Strong
rs2000813	LIPG	Missense variant in endothelial lipase that tags a regulatory haplotype assoc...	Triglycerides & Fatty Acids	Diet	Moderate
rs2072114	FADS2 FADS2 Intron 1 Variant	Intronic FADS2 haplotype tag SNP — the G allele is linked to altered delta-6 ...	Triglycerides & Fatty Acids	Diet	Moderate
rs41380347	MCM6 G-13915T	East African lactase persistence allele — MCM6 enhancer SNP that independentl...	Vitamins & Nutrient Absorption	Diet	Strong
rs3801387	WNT16	Intronic variant affecting cortical bone thickness, bone mineral density, and...	Fitness & Body	Diet	Established
rs2197089	LPL LPL Regulatory Variant	Downstream regulatory variant affecting LPL expression and triglyceride clear...	Triglycerides & Fatty Acids	Diet	Strong
rs4654748	NBPF3	Tag SNP in the NBPF3/ALPL locus on chromosome 1 — the strongest common geneti...	Vitamins & Nutrient Absorption	Diet	Strong
rs4977574	CDKN2B-AS1 9p21.3	9p21.3 CAD risk signal in ANRIL; G allele elevates coronary artery disease ri...	Coronary Artery Disease & Atherosclerosis	Diet	Established
rs7799039	LEP G-2548A	Promoter variant that increases leptin gene expression in adipose tissue, ele...	Appetite & Obesity	Diet	Moderate
rs264	LPL LPL Intron 6 Variant	Intronic LPL variant associated with altered triglyceride clearance and HDL l...	Triglycerides & Fatty Acids	Diet	Moderate
rs987237	TFAP2B	Adipocyte transcription factor variant influencing central fat distribution a...	Appetite & Obesity	Diet	Moderate
rs35333999	PER2 V903I	Missense variant in core circadian clock gene PER2 that lengthens intrinsic c...	Hormones & Sleep	Diet	Strong
rs6902123	PPARD	Intronic PPARD variant that independently impairs hepatic fat mobilization du...	Fitness & Body	Diet	Moderate
rs2854116	APOC3 T-455C	APOC3 promoter variant that disrupts insulin suppression of ApoC-III, raising...	Triglycerides & Fatty Acids	Diet	Strong
rs6133175	SLC23A2	Intronic variant in the tissue vitamin C transporter SVCT2 — GG homozygotes c...	Vitamins & Nutrient Absorption	Diet	Moderate
rs699	AGT M235T	Angiotensinogen level variant affecting blood pressure, sodium sensitivity, a...	Fitness & Body	Diet	Strong
rs61735836	FTCD	Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro...	Vitamins & Nutrient Absorption	Diet	Strong
rs6420424	BCO1	Upstream regulatory variant near BCO1 that reduces beta-carotene to vitamin A...	Vitamins & Nutrient Absorption	Diet	Moderate
rs1979277	SHMT1 C1420T	Alters one-carbon metabolism and folate distribution; influences cancer risk ...	Methylation & Detox	Diet	Moderate
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Blood Sugar & Diabetes	Diet	Strong
rs3211867	CD36	Intronic CD36 variant that reduces CD36 expression, with effects on circulati...	Triglycerides & Fatty Acids	Diet	Moderate
rs6564851	BCO1	Upstream regulatory variant that reduces BCO1 (BCMO1) catalytic activity by ~...	Vitamins & Nutrient Absorption	Diet	Strong
rs7501331	BCO1 Ala379Val	Reduces beta-carotene conversion to vitamin A (retinol) by ~32%, contributing...	Vitamins & Nutrient Absorption	Diet	Strong
rs2236225	MTHFD1 G1958A	Folate processing enzyme — reduced stability increases choline need	Methylation & Detox	Diet	Strong
rs4148102	ABCG1 ABCG1 intronic PUFA-interaction variant	Intronic variant in the ABCG1 cholesterol efflux transporter gene that modifi...	Triglycerides & Fatty Acids	Diet	Emerging
rs366631	GSTM1 Tag SNP for gene deletion	Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi...	Methylation & Detox	Diet	Strong
rs3733890	BHMT R239Q	Missense variant in betaine-homocysteine methyltransferase that reduces enzym...	Methylation & Detox	Diet	Moderate
rs5082	APOA2 -265T>C	Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi...	Triglycerides & Fatty Acids	Diet	Strong
rs4812829	HNF4A HNF4A Intronic T2D Risk Variant	Common intronic variant in HNF4A associated with modestly elevated type 2 dia...	Blood Sugar & Diabetes	Diet	Strong
rs5956	CD36	Synonymous coding variant in CD36 fatty acid translocase; the minor A allele ...	Triglycerides & Fatty Acids	Diet	Emerging
rs4988235	LCT -13910C>T	Lactase persistence - ability to digest lactose (milk sugar) in adulthood	Methylation & Detox	Diet	Established
rs567754	BHMT BHMT-02	Intronic variant in betaine-homocysteine methyltransferase gene associated wi...	Methylation & Detox	Diet	Moderate
rs99780	FADS2	Intronic variant in the FADS1-FADS2 cluster influencing delta-6 desaturase ac...	Triglycerides & Fatty Acids	Diet	Moderate
rs7946	PEMT Val175Met	Phosphatidylcholine production — affects dietary choline requirements	Methylation & Detox	Diet	Strong
rs780095	GCKR GCKR Glucose-Lipid Regulation Variant	Intronic GCKR enhancer variant on the CGG regulatory haplotype; the G allele ...	Blood Sugar & Diabetes	Diet	Moderate
rs7903146	TCF7L2	Main type 2 diabetes risk variant - strongly modulated by dietary fat	Blood Sugar & Diabetes	Diet	Established
rs671	ALDH2 *2	Alcohol metabolism - flush reaction and cancer risk	Pharmacogenomics	Diet	Established
rs762551	CYP1A2 *1F	CYP1A2 *1F intronic inducibility variant — defines fast vs slow caffeine meta...	Pharmacogenomics	Diet	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Neurology & Cognition	Diet	Strong