Tag

Cardiovascular

93 genetic variants with this tag.

RSID	Gene	Description	Category
rs1333049	CDKN2B-AS1 9p21	Strongest genetic risk factor for coronary artery disease and myocardial infa...	Heart & Inflammation	Cardiovascular Diet Lifestyle	Established
rs1801133	MTHFR C677T	Key enzyme for converting folate to its active methylfolate form	Methylation & Detox	Methylation Folate B Vitamins	Established
rs1815739	ACTN3 R577X	Determines presence of alpha-actinin-3 protein in fast-twitch muscle fibers, ...	Fitness & Body	Fitness Muscle Sprint & Power	Strong
rs10455872	LPA	Intronic variant strongly associated with elevated lipoprotein(a) levels and ...	Heart & Inflammation	Cardiovascular Cholesterol Blood Thinners	Established
rs11206244	DIO1 C785T	Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metab...	Hormones & Sleep	Thyroid Hormones Metabolism	Strong
rs8192678	PPARGC1A Gly482Ser	Master regulator of mitochondrial biogenesis affecting aerobic capacity, endu...	Fitness & Body	Fitness Endurance Diabetes	Strong
rs11591147	PCSK9 R46L	Loss-of-function variant that naturally lowers LDL cholesterol by 15-28% and ...	Heart & Inflammation	Cardiovascular Cholesterol Diet	Established
rs1799941	SHBG	Promoter region variant affecting sex hormone-binding globulin levels, with t...	Hormones & Sleep	Hormones & Thyroid Cardiovascular Diabetes	Strong
rs4986790	TLR4 Asp299Gly	Missense variant in Toll-like receptor 4 reducing bacterial endotoxin recogni...	Immune & Gut	Immune System Inflammation Autoimmune	Strong
rs1042713	ADRB2 Arg16Gly	Beta-2 adrenergic receptor variant affecting receptor downregulation, exercis...	Fitness & Body	Fitness Cardiovascular Beta-Agonist	Strong
rs1611115	DBH -1021C>T	Strongest known genetic determinant of dopamine beta-hydroxylase activity, co...	Brain & Mental Health	Cognition Dopamine Neurotransmitters	Strong
rs1800896	IL10 -1082 A>G	Promoter variant affecting IL-10 production — the master anti-inflammatory cy...	Immune & Gut	Immune & Autoimmune Inflammation Autoimmune	Strong
rs429358	APOE E4 determinant	Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high sat...	Nutrition & Metabolism	Cholesterol Cardiovascular Alzheimer's	Established
rs708272	CETP TaqIB	Influences HDL cholesterol levels and particle size through effects on choles...	Heart & Inflammation	Cardiovascular Cholesterol Longevity	Strong
rs1799750	MMP1 1G/2G	Promoter polymorphism affecting MMP1 expression and collagen degradation rate...	Skin & Eyes	Skin, Hair & Pigmentation Cardiovascular Diet	Strong
rs1800629	TNF -308 G>A	Promoter variant increasing TNF-alpha production 2-3 fold, associated with au...	Immune & Gut	Immune & Autoimmune Inflammation Drug Metabolism	Strong
rs693	APOB XbaI (C/T)	Silent variant affecting LDL particle number and lipid metabolism; T allele c...	Heart & Inflammation	Cardiovascular Cholesterol Triglycerides	Strong
rs699	AGT M235T	Angiotensinogen level variant affecting blood pressure, sodium sensitivity, a...	Fitness & Body	Cardiovascular Diet Fitness	Strong
rs7412	APOE E2 determinant	APOE E2 variant - generally protective for cardiovascular health	Nutrition & Metabolism	Cholesterol Cardiovascular Fat Metabolism	Established
rs174547	FADS1	Omega-3 fatty acid conversion efficiency - affects ability to make EPA/DHA fr...	Nutrition & Metabolism	Omega-3 Fat Metabolism Diet	Strong
rs5186	AGTR1 A1166C	3' UTR variant in angiotensin II type 1 receptor affecting blood pressure reg...	Heart & Inflammation	Cardiovascular Drug Metabolism Blood Thinners	Moderate
rs1061170	CFH Y402H	Strongly increases risk of age-related macular degeneration through impaired ...	Skin & Eyes	Eye Health Inflammation Cardiovascular	Established
rs2234693	ESR1 PvuII	Estrogen receptor alpha intron variant affecting receptor expression and estr...	Hormones & Sleep	Hormones & Thyroid Bone Health Cardiovascular	Moderate
rs3135506	APOA5 S19W	Triglyceride metabolism - affects fasting triglyceride levels and cardiovascu...	Nutrition & Metabolism	Triglycerides Cardiovascular Fat Metabolism	Strong
rs4253778	PPARA intron 7 G/C	Regulates fatty acid oxidation and muscle fiber composition, influencing endu...	Fitness & Body	Endurance Exercise Fat Metabolism	Moderate
rs662	PON1 Q192R	Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr...	Heart & Inflammation	Cardiovascular Detoxification Cholesterol	Moderate
rs762551	CYP1A2 *1F	Caffeine metabolism - affects how quickly you process caffeine	Pharmacogenomics	Drug Metabolism Diet Cardiovascular	Strong
rs1205	CRP +1846C>T	3' UTR variant that modulates baseline C-reactive protein levels and inflamma...	Heart & Inflammation	Inflammation Cardiovascular Diabetes	Strong
rs1800795	IL6 -174G/C	Promoter variant controlling interleukin-6 expression — affects inflammation,...	Fitness & Body	Inflammation Cardiovascular Fitness	Strong
rs4149056	SLCO1B1 *5	Statin transport - affects muscle side effect risk with statins	Pharmacogenomics	Drug Metabolism Statins Cardiovascular	Established
rs16944	IL1B -511C>T	Promoter variant affecting IL-1 beta production, influencing inflammatory res...	Heart & Inflammation	Inflammation Cardiovascular Sepsis	Strong
rs2802292	FOXO3	Longevity-associated intronic enhancer variant with 1.9-fold increased probab...	Heart & Inflammation	Longevity Aging Cardiovascular	Established
rs4236601	CAV1	Intergenic variant near caveolin genes affecting primary open-angle glaucoma ...	Skin & Eyes	Eye Health Cardiovascular Aging	Strong
rs6025	F5 Leiden	Factor V Leiden - blood clotting disorder affecting thrombosis risk	Pharmacogenomics	Cardiovascular Blood Thinners	Established
rs234706	CBS C699T	Common synonymous variant in the CBS gene associated with reduced cardiovascu...	Methylation & Detox	Methylation Cardiovascular Folate	Moderate
rs33912345	SIX6 Asn141His	Affects optic nerve development and retinal ganglion cell survival, strongly ...	Skin & Eyes	Eye Health Glaucoma Cardiovascular	Strong
rs4588	GC Thr436Lys	Alters vitamin D binding protein affinity, affecting total and bioavailable 2...	Nutrition & Metabolism	Vitamin D Bone Health Cardiovascular	Strong
rs9536314	KLOTHO F352V (KL-VS)	Longevity-associated variant exhibiting overdominance where heterozygotes sho...	Heart & Inflammation	Mental Health Longevity Cardiovascular	Strong
rs1052373	MYBPC3	Cardiac myosin-binding protein variant strongly associated with endurance ath...	Fitness & Body	Endurance Cardiovascular Fitness	Strong
rs1801181	CBS A360A	A synonymous variant in CBS affecting homocysteine metabolism and associated ...	Methylation & Detox	Methylation Homocysteine B Vitamins	Moderate
rs6511720	LDLR Intron 1	Common regulatory variant in the LDL receptor gene affecting LDLR expression,...	Heart & Inflammation	Cardiovascular Cholesterol Statins	Strong
rs12740374	SORT1 1p13.3 locus	Regulatory variant that increases sortilin expression, lowering LDL cholester...	Heart & Inflammation	Cholesterol Cardiovascular Lipid Metabolism	Established
rs12785878	DHCR7 Near gene T>G	Influences vitamin D synthesis by regulating how much 7-dehydrocholesterol is...	Nutrition & Metabolism	Vitamin D Bone Health Immune System	Strong
rs13107325	SLC39A8 A391T	Zinc and manganese transporter variant that reduces metal ion absorption, aff...	Immune & Gut	Cardiovascular Inflammation Diet	Strong
rs2010963	VEGFA G-634C (+405G>C)	Promoter variant affecting VEGF-A expression and angiogenesis, influencing mu...	Fitness & Body	Angiogenesis Fitness Injury Risk	Strong
rs567754	BHMT BHMT-02	Intronic variant in betaine-homocysteine methyltransferase gene associated wi...	Methylation & Detox	Methylation Homocysteine B Vitamins	Moderate
rs1979277	SHMT1 C1420T	Alters one-carbon metabolism and folate distribution; influences cancer risk,...	Methylation & Detox	Methylation Folate B Vitamins	Moderate
rs2228570	VDR FokI C>T	Vitamin D receptor start codon variant — determines receptor protein length a...	Nutrition & Metabolism	Vitamin D Bone Health Diet	Strong
rs41423247	NR3C1 BclI	Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s...	Brain & Mental Health	Mental Health Stress Response Cortisol	Strong
rs5128	APOC3 3238C>G (SstI)	Regulates triglyceride metabolism through effects on APOC3 expression in the ...	Heart & Inflammation	Triglycerides Cardiovascular Cholesterol	Strong
rs1800947	CRP +1059G>C	Synonymous exon 2 variant that influences baseline C-reactive protein express...	Heart & Inflammation	Inflammation Cardiovascular Cancer Risk	Strong
rs2736100	TERT	Common intron 2 variant in the telomerase gene that influences telomere lengt...	Immune & Gut	Mental Health Telomere Biology Aging	Strong
rs819147	AHCY	Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf...	Methylation & Detox	Methylation Homocysteine Cardiovascular	Moderate
rs12696304	TERC	Regulatory variant near the telomerase RNA gene associated with shorter telom...	Immune & Gut	Mental Health Cardiovascular Diet	Established
rs4073	IL8 -251A>T	Promoter variant affecting interleukin-8 transcription and inflammatory burden	Heart & Inflammation	Inflammation Cardiovascular Heart Disease	Strong
rs11136000	CLU	Intronic variant in clusterin gene affecting Alzheimer's disease risk through...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs1800872	IL10 -592 C>A	Promoter variant affecting IL-10 production — a key anti-inflammatory cytokin...	Heart & Inflammation	Inflammation Cardiovascular Immune & Autoimmune	Strong
rs2287161	CRY1 3' Downstream G>C	Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t...	Hormones & Sleep	Circadian Sleep Chronotype	Strong
rs6994076	TTPA -980T>A	Regulates expression of the alpha-tocopherol transfer protein, the key determ...	Nutrition & Metabolism	Vitamins Vitamin E Diet	Strong
rs75932628	TREM2 R47H	Rare missense variant in microglial receptor TREM2 that significantly increas...	Brain & Mental Health	Alzheimer's Neurological Risk Neuroinflammation	Established
rs3851179	PICALM	Variant in the PICALM gene affecting amyloid-beta clearance across the blood-...	Brain & Mental Health	Alzheimer's Neurological Risk Cardiovascular	Established
rs855791	TMPRSS6 Ala736Val	Master regulator of iron absorption via hepcidin control — the strongest comm...	Nutrition & Metabolism	Iron Cardiovascular Diet	Established
rs1800562	HFE C282Y	Primary variant causing hereditary hemochromatosis type 1, disrupting iron re...	Nutrition & Metabolism	Iron Hemochromatosis Vitamins	Established
rs2231142	ABCG2 Q141K	Reduces ABCG2 transporter function affecting rosuvastatin levels and uric aci...	Pharmacogenomics	Drug Metabolism Statins Cardiovascular	Established
rs3736228	LRP5 A1330V	Wnt signaling co-receptor variant affecting bone mineral density and fracture...	Fitness & Body	Bone & Joint Osteoporosis Cardiovascular	Strong
rs1799945	HFE H63D	Second most common hereditary hemochromatosis variant, mildly increasing iron...	Nutrition & Metabolism	Iron Hemochromatosis Cardiovascular	Established
rs1799983	NOS3 Glu298Asp	Nitric oxide production - reduced activity increases cardiovascular risk and ...	Methylation & Detox	Cardiovascular Nitric Oxide Detoxification	Established
rs2108622	CYP4F2 V433M (*3)	Reduces vitamin K metabolism, requiring higher warfarin doses to achieve anti...	Pharmacogenomics	Drug Metabolism Warfarin Blood Thinners	Established
rs3801387	WNT16	Intronic variant affecting cortical bone thickness, bone mineral density, and...	Fitness & Body	Bone & Joint Cardiovascular Diet	Established
rs13266634	SLC30A8 Arg325Trp (C>T)	Zinc transporter 8 variant affecting zinc loading into insulin granules, infl...	Nutrition & Metabolism	Zinc Insulin Diabetes	Established
rs2070744	NOS3 T-786C promoter	NOS3 expression - controls how much eNOS enzyme is produced for nitric oxide ...	Methylation & Detox	Cardiovascular Nitric Oxide Detoxification	Strong
rs1045642	ABCB1 C3435T	Synonymous variant in P-glycoprotein affecting drug efflux pump expression an...	Pharmacogenomics	Drug Metabolism Pharmacogenomics Immunosuppressants	Moderate
rs3025058	MMP3 5A/6A	Promoter polymorphism affecting MMP3 enzyme expression levels, influencing ca...	Fitness & Body	Bone & Joint Inflammation Cardiovascular	Strong
rs8065080	TRPV1 Ile585Val	Capsaicin receptor variant affecting heat and pain sensitivity	Brain & Mental Health	Pain Sensitivity Neurotransmitters Cardiovascular	Strong
rs9939609	FTO Intron 1 T>A	The most strongly replicated obesity-associated variant, affecting body weigh...	Nutrition & Metabolism	Obesity Metabolic Diabetes	Established
rs17782313	MC4R Near-gene C>T	Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me...	Nutrition & Metabolism	Appetite Obesity Metabolic	Strong
rs4148323	UGT1A1 *6 Gly71Arg	Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc...	Pharmacogenomics	Pharmacogenomics Drug Metabolism Chemotherapy	Established
rs8007267	GCH1	Promoter variant affecting GTP cyclohydrolase 1 expression and pain sensitivi...	Brain & Mental Health	Pain Sensitivity Nitric Oxide Neurotransmitters	Strong
rs9594759	TNFSF11	Regulatory variant in the RANKL gene affecting bone mineral density and osteo...	Fitness & Body	Bone & Joint Cardiovascular Calcium	Strong
rs58542926	TM6SF2 E167K	Lipid transport variant that impairs VLDL secretion, creating a paradoxical t...	Nutrition & Metabolism	Metabolic Cardiovascular Cholesterol	Strong
rs3751143	P2RX7 Glu496Ala	Loss-of-function variant in the P2X7 receptor that reduces inflammatory respo...	Brain & Mental Health	Pain Sensitivity Inflammation Immune Function	Strong
rs4880	SOD2 Val16Ala	Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif...	Methylation & Detox	Detoxification Oxidative Stress Antioxidants	Strong
rs5219	KCNJ11 E23K	Controls the pancreatic beta-cell potassium channel that regulates insulin se...	Nutrition & Metabolism	Diabetes Insulin Metabolic	Strong
rs1050450	GPX1 Pro198Leu	Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the...	Methylation & Detox	Detoxification Oxidative Stress Selenium	Strong
rs2943641	IRS1 Near-gene C>T	Regulates insulin signaling efficiency and cellular glucose uptake	Nutrition & Metabolism	Diabetes Insulin Cardiovascular	Strong
rs1006737	CACNA1C	L-type calcium channel gene variant affecting mood regulation, emotional proc...	Brain & Mental Health	Mental Health Brain Health Mood	Strong
rs28929474	SERPINA1 Z allele (E342K)	Most common alpha-1 antitrypsin deficiency variant causing protein misfolding...	Nutrition & Metabolism	Detoxification Lung Health Liver Disease	Established
rs1138272	GSTP1 Ala114Val	Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ...	Methylation & Detox	Detoxification Glutathione Phase II	Moderate
rs7895833	SIRT1 A>G	Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ...	Nutrition & Metabolism	Mental Health Neurotransmitters Cardiovascular	Moderate
rs17300539	ADIPOQ -11391G>A	Promoter variant affecting adiponectin secretion and metabolic syndrome risk	Nutrition & Metabolism	Nutrition & Metabolism Insulin Diabetes	Strong
rs1800566	NQO1 Pro187Ser (C609T)	Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it...	Methylation & Detox	Detoxification Phase II Oxidative Stress	Strong
rs1048943	CYP1A1 Ile462Val (*2C)	Phase I detoxification enzyme that activates polycyclic aromatic hydrocarbons...	Methylation & Detox	Detoxification Phase I Xenobiotics	Strong
rs1001179	CAT -262C>T	Catalase promoter variant affecting hydrogen peroxide clearance and antioxida...	Methylation & Detox	Detoxification Antioxidants Oxidative Stress	Strong